The role of lipids in cancer progression and metastasis

Lipids have essential biological functions in the body (e.g., providing energy storage, acting as a signaling molecule, and being a structural component of membranes); however, an excess of lipids can promote tumorigenesis, colonization, and metastatic capacity of tumor cells. To metastasize, a tumo...

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Detalles Bibliográficos
Autores: Martín Pérez, Miguel, Urdiroz Urricelqui, Uxue, Bigas, Claudia, Aznar Benitah, Salvador
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/196881
Acceso en línea:https://hdl.handle.net/2445/196881
Access Level:acceso abierto
Palabra clave:Metabolisme dels lípids
Metàstasi
Tractament adjuvant del càncer
Lipid metabolism
Metastasis
Adjuvant treatment of cancer
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spelling The role of lipids in cancer progression and metastasisMartín Pérez, MiguelUrdiroz Urricelqui, UxueBigas, ClaudiaAznar Benitah, SalvadorMetabolisme dels lípidsMetàstasiTractament adjuvant del càncerLipid metabolismMetastasisAdjuvant treatment of cancerLipids have essential biological functions in the body (e.g., providing energy storage, acting as a signaling molecule, and being a structural component of membranes); however, an excess of lipids can promote tumorigenesis, colonization, and metastatic capacity of tumor cells. To metastasize, a tumor cell goes through different stages that require lipid-related metabolic and structural adaptations. These adaptations include altering the lipid membrane composition for invading other niches and overcoming cell death mechanisms and promoting lipid catabolism and anabolism for energy and oxidative stress protective purposes. Cancer cells also harness lipid metabolism to modulate the activity of stromal and immune cells to their advantage and to resist therapy and promote relapse. All this is especially worrying given the high fat intake in Western diets. Thus, metabolic interventions aiming to reduce lipid availability to cancer cells or to exacerbate their metabolic vulnerabilities provide promising therapeutic opportunities to prevent cancer progression and treat metastasis.Cell Press2023202320222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion53 p.application/pdfhttps://hdl.handle.net/2445/196881Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.cmet.2022.09.023Cell Metabolism, 2022, vol. 34, num. 11, p. 1675-1699https://doi.org/10.1016/j.cmet.2022.09.023cc by-nc-nd (c) Elsevier, 2022https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1968812026-05-29T05:05:01Z
dc.title.none.fl_str_mv The role of lipids in cancer progression and metastasis
title The role of lipids in cancer progression and metastasis
spellingShingle The role of lipids in cancer progression and metastasis
Martín Pérez, Miguel
Metabolisme dels lípids
Metàstasi
Tractament adjuvant del càncer
Lipid metabolism
Metastasis
Adjuvant treatment of cancer
title_short The role of lipids in cancer progression and metastasis
title_full The role of lipids in cancer progression and metastasis
title_fullStr The role of lipids in cancer progression and metastasis
title_full_unstemmed The role of lipids in cancer progression and metastasis
title_sort The role of lipids in cancer progression and metastasis
dc.creator.none.fl_str_mv Martín Pérez, Miguel
Urdiroz Urricelqui, Uxue
Bigas, Claudia
Aznar Benitah, Salvador
author Martín Pérez, Miguel
author_facet Martín Pérez, Miguel
Urdiroz Urricelqui, Uxue
Bigas, Claudia
Aznar Benitah, Salvador
author_role author
author2 Urdiroz Urricelqui, Uxue
Bigas, Claudia
Aznar Benitah, Salvador
author2_role author
author
author
dc.subject.none.fl_str_mv Metabolisme dels lípids
Metàstasi
Tractament adjuvant del càncer
Lipid metabolism
Metastasis
Adjuvant treatment of cancer
topic Metabolisme dels lípids
Metàstasi
Tractament adjuvant del càncer
Lipid metabolism
Metastasis
Adjuvant treatment of cancer
description Lipids have essential biological functions in the body (e.g., providing energy storage, acting as a signaling molecule, and being a structural component of membranes); however, an excess of lipids can promote tumorigenesis, colonization, and metastatic capacity of tumor cells. To metastasize, a tumor cell goes through different stages that require lipid-related metabolic and structural adaptations. These adaptations include altering the lipid membrane composition for invading other niches and overcoming cell death mechanisms and promoting lipid catabolism and anabolism for energy and oxidative stress protective purposes. Cancer cells also harness lipid metabolism to modulate the activity of stromal and immune cells to their advantage and to resist therapy and promote relapse. All this is especially worrying given the high fat intake in Western diets. Thus, metabolic interventions aiming to reduce lipid availability to cancer cells or to exacerbate their metabolic vulnerabilities provide promising therapeutic opportunities to prevent cancer progression and treat metastasis.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/196881
url https://hdl.handle.net/2445/196881
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.cmet.2022.09.023
Cell Metabolism, 2022, vol. 34, num. 11, p. 1675-1699
https://doi.org/10.1016/j.cmet.2022.09.023
dc.rights.none.fl_str_mv cc by-nc-nd (c) Elsevier, 2022
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Elsevier, 2022
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 53 p.
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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