Lipid metabolism in metastasis and therapy
Alterations in lipid metabolism are being increasingly implicated in the initiation, aggressiveness, and progression to metastasis of cancers. Recent advances have shown that high levels of fat availability and altered lipid metabolism can promote the metastatic process by i) providing energy for ca...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/183023 |
| Acceso en línea: | https://hdl.handle.net/2445/183023 |
| Access Level: | acceso abierto |
| Palabra clave: | Metabolisme dels lípids Metàstasi Tractament adjuvant del càncer Lipid metabolism Metastasis Adjuvant treatment of cancer |
| Sumario: | Alterations in lipid metabolism are being increasingly implicated in the initiation, aggressiveness, and progression to metastasis of cancers. Recent advances have shown that high levels of fat availability and altered lipid metabolism can promote the metastatic process by i) providing energy for cancer cells, thereby supporting invasion and colonization, ii) promoting their survival by enhancing antioxidative, antiapoptotic mechanisms, and therapy resistance, and iii) inhibiting the immune surveillance from detecting/removing tumor cells. These findings are especially disturbing given the alarmingly high fat intake within our modern diet. However, the reprogramming of fat metabolism exhibited by cancer cells and intratumor immune cells promises to generate new pharmacological opportunities to treat metastasis. © 2021 Elsevier Ltd |
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