Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity

To improve our understanding of the biological relationships among different types of cancer, we have characterized variation in gene expression patterns in a set of 1,707 samples representing 6 human cancer types (breast, ovarian, brain, colorectal, lung adenocarcinoma and squamous cell lung cancer...

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Autores: Prat Aparicio, Aleix, Adamo, Barbara, Fan, Cheng, Peg, Vicente, Vidal Losada, Maria Jesús, Galván, Patricia, Vivancos, Ana, Nuciforo, Paolo, Palmer, Héctor G., Dawood, Shaheenah, Rodón, Jordi, Ramón y Cajal Agüeras, Santiago, Campo, Josep Maria, Felip, Enriqueta, Tabernero Caturla, Josep, Cortés, Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/99123
Acceso en línea:https://hdl.handle.net/2445/99123
Access Level:acceso abierto
Palabra clave:Genòmica
Càncer
Marcadors bioquímics
Assaigs clínics
Oncologia
Genomics
Cancer
Biochemical markers
Clinical trials
Oncology
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spelling Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular EntityPrat Aparicio, AleixAdamo, BarbaraFan, ChengPeg, VicenteVidal Losada, Maria JesúsGalván, PatriciaVivancos, AnaNuciforo, PaoloPalmer, Héctor G.Dawood, ShaheenahRodón, JordiRamón y Cajal Agüeras, SantiagoCampo, Josep MariaFelip, EnriquetaTabernero Caturla, JosepCortés, JavierGenòmicaCàncerMarcadors bioquímicsAssaigs clínicsOncologiaGenomicsCancerBiochemical markersClinical trialsOncologyTo improve our understanding of the biological relationships among different types of cancer, we have characterized variation in gene expression patterns in a set of 1,707 samples representing 6 human cancer types (breast, ovarian, brain, colorectal, lung adenocarcinoma and squamous cell lung cancer). In the unified dataset, breast tumors of the Basal-like subtype were found to represent a unique molecular entity as any other cancer type, including the rest of breast tumors, while showing striking similarities with squamous cell lung cancers. Moreover, gene signatures tracking various cancer- and stromal-related biological processes such as proliferation, hypoxia and immune activation were found expressed similarly in different proportions of tumors across the various cancer types. These data suggest that clinical trials focusing on tumors with common profiles and/or biomarker expression rather than their tissue of origin are warranted with a special focus on Basal-like breast cancer and squamous cell lung carcinoma.Nature Publishing Group2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/99123Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1038/srep03544Scientific Reports, 2013, vol. 3, num. 3544http://dx.doi.org/10.1038/srep03544cc-by-nc-nd (c) Prat Aparicio, Aleix et al., 2013http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/991232026-05-27T06:46:51Z
dc.title.none.fl_str_mv Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity
title Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity
spellingShingle Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity
Prat Aparicio, Aleix
Genòmica
Càncer
Marcadors bioquímics
Assaigs clínics
Oncologia
Genomics
Cancer
Biochemical markers
Clinical trials
Oncology
title_short Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity
title_full Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity
title_fullStr Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity
title_full_unstemmed Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity
title_sort Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity
dc.creator.none.fl_str_mv Prat Aparicio, Aleix
Adamo, Barbara
Fan, Cheng
Peg, Vicente
Vidal Losada, Maria Jesús
Galván, Patricia
Vivancos, Ana
Nuciforo, Paolo
Palmer, Héctor G.
Dawood, Shaheenah
Rodón, Jordi
Ramón y Cajal Agüeras, Santiago
Campo, Josep Maria
Felip, Enriqueta
Tabernero Caturla, Josep
Cortés, Javier
author Prat Aparicio, Aleix
author_facet Prat Aparicio, Aleix
Adamo, Barbara
Fan, Cheng
Peg, Vicente
Vidal Losada, Maria Jesús
Galván, Patricia
Vivancos, Ana
Nuciforo, Paolo
Palmer, Héctor G.
Dawood, Shaheenah
Rodón, Jordi
Ramón y Cajal Agüeras, Santiago
Campo, Josep Maria
Felip, Enriqueta
Tabernero Caturla, Josep
Cortés, Javier
author_role author
author2 Adamo, Barbara
Fan, Cheng
Peg, Vicente
Vidal Losada, Maria Jesús
Galván, Patricia
Vivancos, Ana
Nuciforo, Paolo
Palmer, Héctor G.
Dawood, Shaheenah
Rodón, Jordi
Ramón y Cajal Agüeras, Santiago
Campo, Josep Maria
Felip, Enriqueta
Tabernero Caturla, Josep
Cortés, Javier
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Genòmica
Càncer
Marcadors bioquímics
Assaigs clínics
Oncologia
Genomics
Cancer
Biochemical markers
Clinical trials
Oncology
topic Genòmica
Càncer
Marcadors bioquímics
Assaigs clínics
Oncologia
Genomics
Cancer
Biochemical markers
Clinical trials
Oncology
description To improve our understanding of the biological relationships among different types of cancer, we have characterized variation in gene expression patterns in a set of 1,707 samples representing 6 human cancer types (breast, ovarian, brain, colorectal, lung adenocarcinoma and squamous cell lung cancer). In the unified dataset, breast tumors of the Basal-like subtype were found to represent a unique molecular entity as any other cancer type, including the rest of breast tumors, while showing striking similarities with squamous cell lung cancers. Moreover, gene signatures tracking various cancer- and stromal-related biological processes such as proliferation, hypoxia and immune activation were found expressed similarly in different proportions of tumors across the various cancer types. These data suggest that clinical trials focusing on tumors with common profiles and/or biomarker expression rather than their tissue of origin are warranted with a special focus on Basal-like breast cancer and squamous cell lung carcinoma.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/99123
url https://hdl.handle.net/2445/99123
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1038/srep03544
Scientific Reports, 2013, vol. 3, num. 3544
http://dx.doi.org/10.1038/srep03544
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Prat Aparicio, Aleix et al., 2013
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Prat Aparicio, Aleix et al., 2013
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418300958572544
score 15,198674

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