Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis

Mangiferin, a natural compound isolated from Mangifera indica L, was incorporated in glycerosomes, ethosomes and alternatively in glycerol-ethanol phospholipid vesicles (glycethosomes). Actually, only glycethosomes were able to stably incorporate the mangiferin that was loaded at increasing concentr...

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Autores: Pleguezuelos-Villa, M, Diez-Sales, O, Manca, ML, Manconi, M, Sauri, AR, Escribano-Ferrer, E, Nacher, A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p15540
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/15540
Access Level:acceso abierto
Palabra clave:Mangiferin
Phospholipid vesicles
Glycethosomes
Antioxidant
Skin permeation
Psoriasis
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spelling Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasisPleguezuelos-Villa, MDiez-Sales, OManca, MLManconi, MSauri, AREscribano-Ferrer, ENacher, AMangiferinPhospholipid vesiclesGlycethosomesAntioxidantSkin permeationPsoriasisMangiferin, a natural compound isolated from Mangifera indica L, was incorporated in glycerosomes, ethosomes and alternatively in glycerol-ethanol phospholipid vesicles (glycethosomes). Actually, only glycethosomes were able to stably incorporate the mangiferin that was loaded at increasing concentrations (2, 4, 6, 8 mg/mL). The morphology, size distribution, rheological properties, surface charge and entrapment efficiency of prepared vesicles were deeply measured. All vesicles were mainly spherical, oligolamellar, small in size (similar to 145 nm) and negatively charged (similar to-40 mV), as confirmed by cryo-TEM observation and dynamic laser light scattering measurements. The higher concentration of mangiferin (8 mg/mL) allowed an increase of vesicle mean diameter up to similar to 288 nm. The entrapment efficiency was inversely proportional to the amount of loaded mangiferin. In vitro studies performed by using human abdominal skin, underlined that, the dose-dependent ability of vesicles to promote mangiferin retention in epidermis. In addition, glycethosomes were highly biocompatible and showed a strong ability to protect in vitro the fibroblasts against damages induced by hydrogen peroxide. In vivo results underlined the superior ability of mangiferin loaded glycethosomes respect to the mangiferin dispersion to promote the heal of the wound induced by TPA, confirming their potential application for the treatment of psoriasis or other skin disorders.ELSEVIER2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/15540International Journal of PharmaceuticsISSN: 03785173ISSNe: 18733476reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p155402026-06-07T16:35:31Z
dc.title.none.fl_str_mv Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis
title Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis
spellingShingle Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis
Pleguezuelos-Villa, M
Mangiferin
Phospholipid vesicles
Glycethosomes
Antioxidant
Skin permeation
Psoriasis
title_short Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis
title_full Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis
title_fullStr Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis
title_full_unstemmed Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis
title_sort Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis
dc.creator.none.fl_str_mv Pleguezuelos-Villa, M
Diez-Sales, O
Manca, ML
Manconi, M
Sauri, AR
Escribano-Ferrer, E
Nacher, A
author Pleguezuelos-Villa, M
author_facet Pleguezuelos-Villa, M
Diez-Sales, O
Manca, ML
Manconi, M
Sauri, AR
Escribano-Ferrer, E
Nacher, A
author_role author
author2 Diez-Sales, O
Manca, ML
Manconi, M
Sauri, AR
Escribano-Ferrer, E
Nacher, A
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Mangiferin
Phospholipid vesicles
Glycethosomes
Antioxidant
Skin permeation
Psoriasis
topic Mangiferin
Phospholipid vesicles
Glycethosomes
Antioxidant
Skin permeation
Psoriasis
description Mangiferin, a natural compound isolated from Mangifera indica L, was incorporated in glycerosomes, ethosomes and alternatively in glycerol-ethanol phospholipid vesicles (glycethosomes). Actually, only glycethosomes were able to stably incorporate the mangiferin that was loaded at increasing concentrations (2, 4, 6, 8 mg/mL). The morphology, size distribution, rheological properties, surface charge and entrapment efficiency of prepared vesicles were deeply measured. All vesicles were mainly spherical, oligolamellar, small in size (similar to 145 nm) and negatively charged (similar to-40 mV), as confirmed by cryo-TEM observation and dynamic laser light scattering measurements. The higher concentration of mangiferin (8 mg/mL) allowed an increase of vesicle mean diameter up to similar to 288 nm. The entrapment efficiency was inversely proportional to the amount of loaded mangiferin. In vitro studies performed by using human abdominal skin, underlined that, the dose-dependent ability of vesicles to promote mangiferin retention in epidermis. In addition, glycethosomes were highly biocompatible and showed a strong ability to protect in vitro the fibroblasts against damages induced by hydrogen peroxide. In vivo results underlined the superior ability of mangiferin loaded glycethosomes respect to the mangiferin dispersion to promote the heal of the wound induced by TPA, confirming their potential application for the treatment of psoriasis or other skin disorders.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/15540
url https://incliva.portalinvestigacion.com/publicaciones/15540
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER
publisher.none.fl_str_mv ELSEVIER
dc.source.none.fl_str_mv International Journal of Pharmaceutics
ISSN: 03785173
ISSNe: 18733476
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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