Study of 3,4-dihydroxyphenylalanine (DOPA) as anchoring unit to functionalize biomaterials
This project aims at studying and comparing the efficiency and stability of the binding of a model peptide to a diverse range of biomaterials using L-3,4-dihydroxyphenylalanine (DOPA) which contains catechol groups, as anchoring unit. The capacity of DOPA to bind to metallic biomaterials such as tit...
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| Tipo de recurso: | tesis de maestría |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/114809 |
| Acceso en línea: | https://hdl.handle.net/2117/114809 |
| Access Level: | acceso abierto |
| Palabra clave: | Biomaterials Àrees temàtiques de la UPC::Enginyeria dels materials |
| Sumario: | This project aims at studying and comparing the efficiency and stability of the binding of a model peptide to a diverse range of biomaterials using L-3,4-dihydroxyphenylalanine (DOPA) which contains catechol groups, as anchoring unit. The capacity of DOPA to bind to metallic biomaterials such as titanium is well described; however, the binding to other types of materials, i.e. ceramics and polymers, needs to be explored. In particular, the functionalization of alpha-tricalcium phosphate (α-TCP), polymethylpentene or poly(4-methyl-1-pentene) (PMP), poly(lactic acid) (PLA), chitosan and alginate will be studied. |
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