Ulcerative colitis model triggers gut α-Synuclein aggregation without brain involvement or neuronal loss in female rats

[Introduction:] Despite being the second most common neurodegenerative disorder, the mechanisms underlying the onset and progression of Parkinson’s disease (PD) remain poorly understood, and no curative treatment is currently available. The Braak hypothesis offers an intriguing framework for explain...

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Bibliographic Details
Authors: Espinosa-Oliva, Ana M., Vázquez-Carretero, María D., Ruiz, Rocío, Roca-Ceballos, María Angustias, García-Miranda, Pablo, Peral, María J., Sarmiento Soto, Manuel, Herrera, Antonio José, Venero, José Luis, Pablos, Rocío M. de
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/420262
Online Access:http://hdl.handle.net/10261/420262
https://api.elsevier.com/content/abstract/scopus_id/105027858217
Access Level:Open access
Keyword:Parkinson disease
Gut-brain axis
Inflammation
Neurodegeneration
Sex differences
Ulcerative colitis
α-Synuclein
Description
Summary:[Introduction:] Despite being the second most common neurodegenerative disorder, the mechanisms underlying the onset and progression of Parkinson’s disease (PD) remain poorly understood, and no curative treatment is currently available. The Braak hypothesis offers an intriguing framework for explaining both the origin and development of the disease, proposing that PD begins in the gut and subsequently spreads to the brain.

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