Ulcerative colitis model triggers gut α-Synuclein aggregation without brain involvement or neuronal loss in female rats

[Introduction:] Despite being the second most common neurodegenerative disorder, the mechanisms underlying the onset and progression of Parkinson’s disease (PD) remain poorly understood, and no curative treatment is currently available. The Braak hypothesis offers an intriguing framework for explain...

Descripción completa

Detalles Bibliográficos
Autores: Espinosa-Oliva, Ana M., Vázquez-Carretero, María D., Ruiz, Rocío, Roca-Ceballos, María Angustias, García-Miranda, Pablo, Peral, María J., Sarmiento Soto, Manuel, Herrera, Antonio José, Venero, José Luis, Pablos, Rocío M. de
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/420262
Acceso en línea:http://hdl.handle.net/10261/420262
https://api.elsevier.com/content/abstract/scopus_id/105027858217
Access Level:acceso abierto
Palabra clave:Parkinson disease
Gut-brain axis
Inflammation
Neurodegeneration
Sex differences
Ulcerative colitis
α-Synuclein
Descripción
Sumario:[Introduction:] Despite being the second most common neurodegenerative disorder, the mechanisms underlying the onset and progression of Parkinson’s disease (PD) remain poorly understood, and no curative treatment is currently available. The Braak hypothesis offers an intriguing framework for explaining both the origin and development of the disease, proposing that PD begins in the gut and subsequently spreads to the brain.

Similares en LA Referencia