Crosstalk between HGF and TGF-ß signaling pathways in adult liver progenitor cells and hepatocellular carcinoma cells

Chronic liver diseases (CLDs) are associated with fibrosis, which eventually progress to cirrhosis and ultimately to hepatocellular carcinoma (HCC) development, constituting a major global health problem. In the context of chronic liver injury where the proliferative capacity of adult hepatic cells...

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Detalles Bibliográficos
Autor: Almale Del Barrio, Laura
Tipo de recurso: tesis doctoral
Fecha de publicación:2019
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/10767
Acceso en línea:https://hdl.handle.net/20.500.14352/10767
Access Level:acceso abierto
Palabra clave:616.36(043.2)
Hígado
Liver
Gastroenterología y hepatología
Oncología
3205.03 Gastroenterología
3201.01 Oncología
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spelling Crosstalk between HGF and TGF-ß signaling pathways in adult liver progenitor cells and hepatocellular carcinoma cellsInteracción entre las vías de HGF y TGF-ß en células progenitoras adultas hepáticas y células de hepatocarcinomaAlmale Del Barrio, Laura616.36(043.2)HígadoLiverGastroenterología y hepatologíaOncología3205.03 Gastroenterología3201.01 OncologíaChronic liver diseases (CLDs) are associated with fibrosis, which eventually progress to cirrhosis and ultimately to hepatocellular carcinoma (HCC) development, constituting a major global health problem. In the context of chronic liver injury where the proliferative capacity of adult hepatic cells is impaired, the population of adult hepatic progenitor cells (HPCs), also known as oval cells in rodents, takes over the regenerative process. Upon activation, HPCs/oval cells expand, proliferate and migrate into liver parenchyma and due to their bipotential nature differentiate into hepatocytes and cholangiocytes compensating the cellular loss and maintaining liver functionality. However, some authors give HPCs/oval cells a pro-fibrotic role, establishing a direct relationship between the HPCs/oval cell expansion and the severity of thefibrosis. They could also be the cells of origin of a subset of HCC. It is therefore evident that the signals and mechanisms regulating HPC/oval cell biology and function need to be clarified not only because of their potential utility in regenerative medicine, but also because of their still uncertain role in the aforementioned diseases..Las enfermedades hepáticas crónicas (CLD) están asociadas con fibrosis, que eventualmente progresa a cirrosis, y en último término al desarrollo de un carcinoma hepatocelular (HCC), y constituyen un importante problema de salud global. En este contexto de daño hepático crónico en el que la capacidad regenerativa de las células maduras hepáticas se ve comprometida, es la población de células progenitoras adultas (HPCs), también conocidas como células ovales en modelos murinos, la que va a tomar las riendas del proceso de regeneración hepática. Tras su activación, las HPCs/células ovales se expanden,proliferan y migran en el parénquima hepático y gracias a su naturaleza bipotencial se diferencian a hepatocitos y colangiocitos, compensando así la pérdida de masa hepática y manteniendo la funcionalidad hepática. Sin embargo, algunos autores dotan a las HPCs/células ovales de un papel profibrótico, estableciendo una relación directa entre su expansión y la severidad de la fibrosis. Estas células también pueden ser el origen celular de algunos subtipos de HCC. Resulta por tanto evidente la necesidad de estudiar las señales y mecanismos que regulan la biología y la función de estas células, no solo por su potencial utilidad en medicina regenerativa sino también por su papel aún no claro en las ya mencionadas enfermedades hepáticas...Universidad Complutense de MadridSánchez Muñoz, AranzazuHerrera González, Blanca MaríaUniversidad Complutense de Madrid20192019-12-1820192019-12-18doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/10767reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/107672026-06-02T12:44:21Z
dc.title.none.fl_str_mv Crosstalk between HGF and TGF-ß signaling pathways in adult liver progenitor cells and hepatocellular carcinoma cells
Interacción entre las vías de HGF y TGF-ß en células progenitoras adultas hepáticas y células de hepatocarcinoma
title Crosstalk between HGF and TGF-ß signaling pathways in adult liver progenitor cells and hepatocellular carcinoma cells
spellingShingle Crosstalk between HGF and TGF-ß signaling pathways in adult liver progenitor cells and hepatocellular carcinoma cells
Almale Del Barrio, Laura
616.36(043.2)
Hígado
Liver
Gastroenterología y hepatología
Oncología
3205.03 Gastroenterología
3201.01 Oncología
title_short Crosstalk between HGF and TGF-ß signaling pathways in adult liver progenitor cells and hepatocellular carcinoma cells
title_full Crosstalk between HGF and TGF-ß signaling pathways in adult liver progenitor cells and hepatocellular carcinoma cells
title_fullStr Crosstalk between HGF and TGF-ß signaling pathways in adult liver progenitor cells and hepatocellular carcinoma cells
title_full_unstemmed Crosstalk between HGF and TGF-ß signaling pathways in adult liver progenitor cells and hepatocellular carcinoma cells
title_sort Crosstalk between HGF and TGF-ß signaling pathways in adult liver progenitor cells and hepatocellular carcinoma cells
dc.creator.none.fl_str_mv Almale Del Barrio, Laura
author Almale Del Barrio, Laura
author_facet Almale Del Barrio, Laura
author_role author
dc.contributor.none.fl_str_mv Sánchez Muñoz, Aranzazu
Herrera González, Blanca María
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.36(043.2)
Hígado
Liver
Gastroenterología y hepatología
Oncología
3205.03 Gastroenterología
3201.01 Oncología
topic 616.36(043.2)
Hígado
Liver
Gastroenterología y hepatología
Oncología
3205.03 Gastroenterología
3201.01 Oncología
description Chronic liver diseases (CLDs) are associated with fibrosis, which eventually progress to cirrhosis and ultimately to hepatocellular carcinoma (HCC) development, constituting a major global health problem. In the context of chronic liver injury where the proliferative capacity of adult hepatic cells is impaired, the population of adult hepatic progenitor cells (HPCs), also known as oval cells in rodents, takes over the regenerative process. Upon activation, HPCs/oval cells expand, proliferate and migrate into liver parenchyma and due to their bipotential nature differentiate into hepatocytes and cholangiocytes compensating the cellular loss and maintaining liver functionality. However, some authors give HPCs/oval cells a pro-fibrotic role, establishing a direct relationship between the HPCs/oval cell expansion and the severity of thefibrosis. They could also be the cells of origin of a subset of HCC. It is therefore evident that the signals and mechanisms regulating HPC/oval cell biology and function need to be clarified not only because of their potential utility in regenerative medicine, but also because of their still uncertain role in the aforementioned diseases..
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-12-18
2019
2019-12-18
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/10767
url https://hdl.handle.net/20.500.14352/10767
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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