Crosstalk between HGF and TGF-ß signaling pathways in adult liver progenitor cells and hepatocellular carcinoma cells
Chronic liver diseases (CLDs) are associated with fibrosis, which eventually progress to cirrhosis and ultimately to hepatocellular carcinoma (HCC) development, constituting a major global health problem. In the context of chronic liver injury where the proliferative capacity of adult hepatic cells...
| Autor: | |
|---|---|
| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/10767 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/10767 |
| Access Level: | acceso abierto |
| Palabra clave: | 616.36(043.2) Hígado Liver Gastroenterología y hepatología Oncología 3205.03 Gastroenterología 3201.01 Oncología |
| Sumario: | Chronic liver diseases (CLDs) are associated with fibrosis, which eventually progress to cirrhosis and ultimately to hepatocellular carcinoma (HCC) development, constituting a major global health problem. In the context of chronic liver injury where the proliferative capacity of adult hepatic cells is impaired, the population of adult hepatic progenitor cells (HPCs), also known as oval cells in rodents, takes over the regenerative process. Upon activation, HPCs/oval cells expand, proliferate and migrate into liver parenchyma and due to their bipotential nature differentiate into hepatocytes and cholangiocytes compensating the cellular loss and maintaining liver functionality. However, some authors give HPCs/oval cells a pro-fibrotic role, establishing a direct relationship between the HPCs/oval cell expansion and the severity of thefibrosis. They could also be the cells of origin of a subset of HCC. It is therefore evident that the signals and mechanisms regulating HPC/oval cell biology and function need to be clarified not only because of their potential utility in regenerative medicine, but also because of their still uncertain role in the aforementioned diseases.. |
|---|