Positive impact of a faecal-based screening programme on colorectal cancer mortality risk

Introduction The effectiveness of colorectal cancer (CRC) screening programs is directly related to participation and the number of interval CRCs. The objective was to analyse specific-mortality in a cohort of individuals invited to a CRC screening program according to type of CRC diagnosis (screen-...

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Authors: Ibáñez Sanz, Gemma, Milà, Núria, Vidal Lancis, Maria Carmen, Rocamora, Judith, Moreno Aguado, Víctor, Sanz Pamplona, Rebeca, García Martínez, Montserrat, MSIC-SC Research Group
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/179296
Online Access:https://hdl.handle.net/2445/179296
Access Level:Open access
Keyword:Càncer colorectal
Cribratge
Mortalitat
Colorectal cancer
Medical screening
Mortality
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spelling Positive impact of a faecal-based screening programme on colorectal cancer mortality riskIbáñez Sanz, GemmaMilà, NúriaVidal Lancis, Maria CarmenRocamora, JudithMoreno Aguado, VíctorSanz Pamplona, RebecaGarcía Martínez, MontserratMSIC-SC Research GroupCàncer colorectalCribratgeMortalitatColorectal cancerMedical screeningMortalityIntroduction The effectiveness of colorectal cancer (CRC) screening programs is directly related to participation and the number of interval CRCs. The objective was to analyse specific-mortality in a cohort of individuals invited to a CRC screening program according to type of CRC diagnosis (screen-detected cancers, interval cancers, and cancers among the non-uptake group). Material and methods Retrospective cohort that included invitees aged 50-69 years of a CRC screening program (target population of 85,000 people) in Catalonia (Spain) from 2000-2015 with mortality follow-up until 2020. A screen-detected CRC was a cancer diagnosed after a positive faecal occult blood test (guaiac or immunochemical); an interval cancer was a cancer diagnosed after a negative test result and before the next invitation to the program (<= 24 months); a non-uptake cancer was a cancer in subjects who declined screening. Results A total of 624 people were diagnosed with CRC (n = 265 screen-detected, n = 103 interval cancers, n = 256 non-uptake). In the multivariate analysis, we observed a 74% increase in mortality rate in the group with interval CRC compared to screen-detected CRC adjusted for age, sex, location and stage (HR: 1.74%, 95% CI:1.08-2.82, P = 0.02). These differences were found even when we restricted for advanced-cancers participants. In the stratified analysis for type of faecal occult blood test, a lower mortality rate was only observed among FIT screen-detected CRCs. Conclusion CRC screening with the FIT was associated with a significant reduction in CRC mortality.Public Library of Science (PLoS)2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/179296Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0253369PLOS ONE, 2021, vol.16, num. 6, p. e0253369https://doi.org/10.1371/journal.pone.0253369cc by (c) Ibáñez Sanz, Gemma et al., 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1792962026-05-27T06:46:51Z
dc.title.none.fl_str_mv Positive impact of a faecal-based screening programme on colorectal cancer mortality risk
title Positive impact of a faecal-based screening programme on colorectal cancer mortality risk
spellingShingle Positive impact of a faecal-based screening programme on colorectal cancer mortality risk
Ibáñez Sanz, Gemma
Càncer colorectal
Cribratge
Mortalitat
Colorectal cancer
Medical screening
Mortality
title_short Positive impact of a faecal-based screening programme on colorectal cancer mortality risk
title_full Positive impact of a faecal-based screening programme on colorectal cancer mortality risk
title_fullStr Positive impact of a faecal-based screening programme on colorectal cancer mortality risk
title_full_unstemmed Positive impact of a faecal-based screening programme on colorectal cancer mortality risk
title_sort Positive impact of a faecal-based screening programme on colorectal cancer mortality risk
dc.creator.none.fl_str_mv Ibáñez Sanz, Gemma
Milà, Núria
Vidal Lancis, Maria Carmen
Rocamora, Judith
Moreno Aguado, Víctor
Sanz Pamplona, Rebeca
García Martínez, Montserrat
MSIC-SC Research Group
author Ibáñez Sanz, Gemma
author_facet Ibáñez Sanz, Gemma
Milà, Núria
Vidal Lancis, Maria Carmen
Rocamora, Judith
Moreno Aguado, Víctor
Sanz Pamplona, Rebeca
García Martínez, Montserrat
MSIC-SC Research Group
author_role author
author2 Milà, Núria
Vidal Lancis, Maria Carmen
Rocamora, Judith
Moreno Aguado, Víctor
Sanz Pamplona, Rebeca
García Martínez, Montserrat
MSIC-SC Research Group
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer colorectal
Cribratge
Mortalitat
Colorectal cancer
Medical screening
Mortality
topic Càncer colorectal
Cribratge
Mortalitat
Colorectal cancer
Medical screening
Mortality
description Introduction The effectiveness of colorectal cancer (CRC) screening programs is directly related to participation and the number of interval CRCs. The objective was to analyse specific-mortality in a cohort of individuals invited to a CRC screening program according to type of CRC diagnosis (screen-detected cancers, interval cancers, and cancers among the non-uptake group). Material and methods Retrospective cohort that included invitees aged 50-69 years of a CRC screening program (target population of 85,000 people) in Catalonia (Spain) from 2000-2015 with mortality follow-up until 2020. A screen-detected CRC was a cancer diagnosed after a positive faecal occult blood test (guaiac or immunochemical); an interval cancer was a cancer diagnosed after a negative test result and before the next invitation to the program (<= 24 months); a non-uptake cancer was a cancer in subjects who declined screening. Results A total of 624 people were diagnosed with CRC (n = 265 screen-detected, n = 103 interval cancers, n = 256 non-uptake). In the multivariate analysis, we observed a 74% increase in mortality rate in the group with interval CRC compared to screen-detected CRC adjusted for age, sex, location and stage (HR: 1.74%, 95% CI:1.08-2.82, P = 0.02). These differences were found even when we restricted for advanced-cancers participants. In the stratified analysis for type of faecal occult blood test, a lower mortality rate was only observed among FIT screen-detected CRCs. Conclusion CRC screening with the FIT was associated with a significant reduction in CRC mortality.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/179296
url https://hdl.handle.net/2445/179296
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0253369
PLOS ONE, 2021, vol.16, num. 6, p. e0253369
https://doi.org/10.1371/journal.pone.0253369
dc.rights.none.fl_str_mv cc by (c) Ibáñez Sanz, Gemma et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Ibáñez Sanz, Gemma et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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