Evolutionary Analysis of DELLA-Associated Transcriptional Networks
[EN] DELLA proteins are transcriptional regulators present in all land plants which have been shown to modulate the activity of over 100 transcription factors in Arabidopsis, involved in multiple physiological and developmental processes. It has been proposed that DELLAs transduce environmental info...
| Autores: | , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Recursos: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/101837 |
| Acesso em linha: | https://riunet.upv.es/handle/10251/101837 |
| Access Level: | acceso abierto |
| Palavra-chave: | Gene co-expression networks Integrative molecular systems biology Evo-devo Transcriptional regulation Plant signaling GENETICA BIOQUIMICA Y BIOLOGIA MOLECULAR |
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Evolutionary Analysis of DELLA-Associated Transcriptional NetworksBriones-Moreno, AsierBLAZQUEZ, MIGUEL-ANGEL|||0000-0001-5743-0448Hernández-García, JorgeVargas-Chávez, C.Romero-Campero FJRomero, J.M.Valverde, F.Gene co-expression networksIntegrative molecular systems biologyEvo-devoTranscriptional regulationPlant signalingGENETICABIOQUIMICA Y BIOLOGIA MOLECULAR[EN] DELLA proteins are transcriptional regulators present in all land plants which have been shown to modulate the activity of over 100 transcription factors in Arabidopsis, involved in multiple physiological and developmental processes. It has been proposed that DELLAs transduce environmental information to pre-wired transcriptional circuits because their stability is regulated by gibberellins (GAs), whose homeostasis largely depends on environmental signals. The ability of GAs to promote DELLA degradation coincides with the origin of vascular plants, but the presence of DELLAs in other land plants poses at least two questions: what regulatory properties have DELLAs provided to the behavior of transcriptional networks in land plants, and how has the recruitment of DELLAs by GA signaling affected this regulation. To address these issues, we have constructed gene co-expression networks of four different organisms within the green lineage with different properties regarding DELLAs: Arabidopsis thaliana and Solanum lycopersicum (both with GA- regulated DELLA proteins), Physcomitrella patens (with GA- independent DELLA proteins) and Chlamydomonas reinhardtii (a green alga without DELLA), and we have examined the relative evolution of the subnetworks containing the potential DELLA-dependent transcriptomes. Network analysis indicates a relative increase in parameters associated with the degree of interconnectivity in the DELLA-associated subnetworks of land plants, with a stronger effect in species with GA- regulated DELLA proteins. These results suggest that DELLAs may have played a role in the coordination of multiple transcriptional programs along evolution, and the function of DELLAs as regulatory 'hubs' became further consolidated after their recruitment by GA signaling in higher plants.Work in the laboratories was funded by grants BFU2016-80621-P and BIO2014-52425-P of the Spanish Ministry of Economy, Industry and Competitiveness, and H2020-MSCA-RISE-2014-644435 of the European Union. AB-M and JH-G hold Fellowships of the Spanish Ministry of Education, Culture and Sport FPU14/01941 and FPU15/01756, respectively.Frontiers Media SAInstituto Universitario Mixto de Biología Molecular y Celular de PlantasEuropean CommissionMinisterio de Economía y CompetitividadRepositorio Institucional de la Universitat Politècnica de València Riunet20172017-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/101837reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 BIO2014-52425-P INTERACCION ENTRE LAS SEÑALES DE NUTRIENTES, LUZ Y TEMPERATURA EN LA TRANSICION FLORAL EN ARABIDOPSISEuropean Commission https://doi.org/10.13039/501100000780 H2020 644435 Evaluation of Plant Signaling Networks in Natural EnvironmentsMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 BFU2016-80621-P ANÁLISIS EVOLUTIVO DE UN 'HUB' FUNCIONAL EN PLANTASopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1018372026-06-13T07:49:27Z |
| dc.title.none.fl_str_mv |
Evolutionary Analysis of DELLA-Associated Transcriptional Networks |
| title |
Evolutionary Analysis of DELLA-Associated Transcriptional Networks |
| spellingShingle |
Evolutionary Analysis of DELLA-Associated Transcriptional Networks Briones-Moreno, Asier Gene co-expression networks Integrative molecular systems biology Evo-devo Transcriptional regulation Plant signaling GENETICA BIOQUIMICA Y BIOLOGIA MOLECULAR |
| title_short |
Evolutionary Analysis of DELLA-Associated Transcriptional Networks |
| title_full |
Evolutionary Analysis of DELLA-Associated Transcriptional Networks |
| title_fullStr |
Evolutionary Analysis of DELLA-Associated Transcriptional Networks |
| title_full_unstemmed |
Evolutionary Analysis of DELLA-Associated Transcriptional Networks |
| title_sort |
Evolutionary Analysis of DELLA-Associated Transcriptional Networks |
| dc.creator.none.fl_str_mv |
Briones-Moreno, Asier BLAZQUEZ, MIGUEL-ANGEL|||0000-0001-5743-0448 Hernández-García, Jorge Vargas-Chávez, C. Romero-Campero FJ Romero, J.M. Valverde, F. |
| author |
Briones-Moreno, Asier |
| author_facet |
Briones-Moreno, Asier BLAZQUEZ, MIGUEL-ANGEL|||0000-0001-5743-0448 Hernández-García, Jorge Vargas-Chávez, C. Romero-Campero FJ Romero, J.M. Valverde, F. |
| author_role |
author |
| author2 |
BLAZQUEZ, MIGUEL-ANGEL|||0000-0001-5743-0448 Hernández-García, Jorge Vargas-Chávez, C. Romero-Campero FJ Romero, J.M. Valverde, F. |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto Universitario Mixto de Biología Molecular y Celular de Plantas European Commission Ministerio de Economía y Competitividad Repositorio Institucional de la Universitat Politècnica de València Riunet |
| dc.subject.none.fl_str_mv |
Gene co-expression networks Integrative molecular systems biology Evo-devo Transcriptional regulation Plant signaling GENETICA BIOQUIMICA Y BIOLOGIA MOLECULAR |
| topic |
Gene co-expression networks Integrative molecular systems biology Evo-devo Transcriptional regulation Plant signaling GENETICA BIOQUIMICA Y BIOLOGIA MOLECULAR |
| description |
[EN] DELLA proteins are transcriptional regulators present in all land plants which have been shown to modulate the activity of over 100 transcription factors in Arabidopsis, involved in multiple physiological and developmental processes. It has been proposed that DELLAs transduce environmental information to pre-wired transcriptional circuits because their stability is regulated by gibberellins (GAs), whose homeostasis largely depends on environmental signals. The ability of GAs to promote DELLA degradation coincides with the origin of vascular plants, but the presence of DELLAs in other land plants poses at least two questions: what regulatory properties have DELLAs provided to the behavior of transcriptional networks in land plants, and how has the recruitment of DELLAs by GA signaling affected this regulation. To address these issues, we have constructed gene co-expression networks of four different organisms within the green lineage with different properties regarding DELLAs: Arabidopsis thaliana and Solanum lycopersicum (both with GA- regulated DELLA proteins), Physcomitrella patens (with GA- independent DELLA proteins) and Chlamydomonas reinhardtii (a green alga without DELLA), and we have examined the relative evolution of the subnetworks containing the potential DELLA-dependent transcriptomes. Network analysis indicates a relative increase in parameters associated with the degree of interconnectivity in the DELLA-associated subnetworks of land plants, with a stronger effect in species with GA- regulated DELLA proteins. These results suggest that DELLAs may have played a role in the coordination of multiple transcriptional programs along evolution, and the function of DELLAs as regulatory 'hubs' became further consolidated after their recruitment by GA signaling in higher plants. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2017-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://riunet.upv.es/handle/10251/101837 |
| url |
https://riunet.upv.es/handle/10251/101837 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 BIO2014-52425-P INTERACCION ENTRE LAS SEÑALES DE NUTRIENTES, LUZ Y TEMPERATURA EN LA TRANSICION FLORAL EN ARABIDOPSIS European Commission https://doi.org/10.13039/501100000780 H2020 644435 Evaluation of Plant Signaling Networks in Natural Environments Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 BFU2016-80621-P ANÁLISIS EVOLUTIVO DE UN 'HUB' FUNCIONAL EN PLANTAS |
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open access http://purl.org/coar/access_right/c_abf2 Reconocimiento (by) http://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Reconocimiento (by) http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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Frontiers Media SA |
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Frontiers Media SA |
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reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname:Universitat Politècnica de València (UPV) |
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