Killing in the name of: T6SS structure and effector diversity

The life of bacteria is challenging, to endure bacteria employ a range of mechanisms to optimize their environment, including deploying the type VI secretion system (T6SS). Acting as a bacterial crossbow, this system delivers effectors responsible for subverting host cells, killing competitors and f...

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Detalhes bibliográficos
Autores: Allsopp, Luke P., Bernal Guzmán, Patricia
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2023
País:España
Recursos:Universidad de Sevilla (US)
Repositório:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/148216
Acesso em linha:https://hdl.handle.net/11441/148216
https://doi.org/10.1099/mic.0.001367
Access Level:Acceso aberto
Palavra-chave:Type VI secretion system
T6SS
antimicrobial effectors
antieukaryotic effectors
T6SS assembly
membrane complex
baseplate
tail
inner tube
contractile sheath
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spelling Killing in the name of: T6SS structure and effector diversityAllsopp, Luke P.Bernal Guzmán, PatriciaType VI secretion systemT6SSantimicrobial effectorsantieukaryotic effectorsT6SS assemblymembrane complexbaseplatetailinner tubecontractile sheathThe life of bacteria is challenging, to endure bacteria employ a range of mechanisms to optimize their environment, including deploying the type VI secretion system (T6SS). Acting as a bacterial crossbow, this system delivers effectors responsible for subverting host cells, killing competitors and facilitating general secretion to access common goods. Due to its importance, this lethal machine has been evolutionarily maintained, disseminated and specialized to fulfil these vital functions. In fact, T6SS structural clusters are present in over 25% of Gram-negative bacteria, varying in number from one to six different genetic clusters per organism. Since its discovery in 2006, research on the T6SS has rapidly progressed, yielding remarkable breakthroughs. The identification and characterization of novel components of the T6SS, combined with biochemical and structural studies, have revealed fascinating mechanisms governing its assembly, loading, firing and disassembly processes. Recent findings have also demonstrated the efficacy of this system against fungal and Gram-positive cells, expanding its scope. Ongoing research continues to uncover an extensive and expanding repertoire of T6SS effectors, the genuine mediators of T6SS function. These studies are shedding light on new aspects of the biology of prokaryotic and eukaryotic organisms. This review provides a comprehensive overview of the T6SS, highlighting recent discoveries of its structure and the diversity of its effectors. Additionally, it injects a personal perspective on avenues for future research, aiming to deepen our understanding of this combative system.Academy of Medical Sciences/the Wellcome Trust/the Government Department of Business, Energy and Industrial Strategy/the British Heart Foundation/Diabetes UK Springboard Award - SBF006\1161Ministerio de Ciencia e Innovación de España (MCIN), Agencia Estatal de Investigación (AEI) la Unión Europea (UE) - PID2021-123000OB-I00 y TED2021-130357B-I00Microbiology SocietyMicrobiologíaWellcome Trust. UK.Government Department of Business, Energy and Industrial Strategy. UK.Ministerio de Ciencia e Innovación (MICIN). EspañaAgencia Estatal de Investigación. EspañaEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/148216https://doi.org/10.1099/mic.0.001367reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésMicrobiology, 169 (7), 001367.SBF006\1161PID2021-123000OB-I00TED2021-130357B-I00https://doi.org/10.1099/mic.0.001367info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1482162026-06-17T12:51:07Z
dc.title.none.fl_str_mv Killing in the name of: T6SS structure and effector diversity
title Killing in the name of: T6SS structure and effector diversity
spellingShingle Killing in the name of: T6SS structure and effector diversity
Allsopp, Luke P.
Type VI secretion system
T6SS
antimicrobial effectors
antieukaryotic effectors
T6SS assembly
membrane complex
baseplate
tail
inner tube
contractile sheath
title_short Killing in the name of: T6SS structure and effector diversity
title_full Killing in the name of: T6SS structure and effector diversity
title_fullStr Killing in the name of: T6SS structure and effector diversity
title_full_unstemmed Killing in the name of: T6SS structure and effector diversity
title_sort Killing in the name of: T6SS structure and effector diversity
dc.creator.none.fl_str_mv Allsopp, Luke P.
Bernal Guzmán, Patricia
author Allsopp, Luke P.
author_facet Allsopp, Luke P.
Bernal Guzmán, Patricia
author_role author
author2 Bernal Guzmán, Patricia
author2_role author
dc.contributor.none.fl_str_mv Microbiología
Wellcome Trust. UK.
Government Department of Business, Energy and Industrial Strategy. UK.
Ministerio de Ciencia e Innovación (MICIN). España
Agencia Estatal de Investigación. España
European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)
dc.subject.none.fl_str_mv Type VI secretion system
T6SS
antimicrobial effectors
antieukaryotic effectors
T6SS assembly
membrane complex
baseplate
tail
inner tube
contractile sheath
topic Type VI secretion system
T6SS
antimicrobial effectors
antieukaryotic effectors
T6SS assembly
membrane complex
baseplate
tail
inner tube
contractile sheath
description The life of bacteria is challenging, to endure bacteria employ a range of mechanisms to optimize their environment, including deploying the type VI secretion system (T6SS). Acting as a bacterial crossbow, this system delivers effectors responsible for subverting host cells, killing competitors and facilitating general secretion to access common goods. Due to its importance, this lethal machine has been evolutionarily maintained, disseminated and specialized to fulfil these vital functions. In fact, T6SS structural clusters are present in over 25% of Gram-negative bacteria, varying in number from one to six different genetic clusters per organism. Since its discovery in 2006, research on the T6SS has rapidly progressed, yielding remarkable breakthroughs. The identification and characterization of novel components of the T6SS, combined with biochemical and structural studies, have revealed fascinating mechanisms governing its assembly, loading, firing and disassembly processes. Recent findings have also demonstrated the efficacy of this system against fungal and Gram-positive cells, expanding its scope. Ongoing research continues to uncover an extensive and expanding repertoire of T6SS effectors, the genuine mediators of T6SS function. These studies are shedding light on new aspects of the biology of prokaryotic and eukaryotic organisms. This review provides a comprehensive overview of the T6SS, highlighting recent discoveries of its structure and the diversity of its effectors. Additionally, it injects a personal perspective on avenues for future research, aiming to deepen our understanding of this combative system.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/148216
https://doi.org/10.1099/mic.0.001367
url https://hdl.handle.net/11441/148216
https://doi.org/10.1099/mic.0.001367
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Microbiology, 169 (7), 001367.
SBF006\1161
PID2021-123000OB-I00
TED2021-130357B-I00
https://doi.org/10.1099/mic.0.001367
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Microbiology Society
publisher.none.fl_str_mv Microbiology Society
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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