Bone morphogenetic protein 2 is a new molecular target linked to non-alcoholic fatty liver disease with potential value as non-invasive screening tool

Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease worldwide, being non-alcoholic steatohepatitis (NASH) its most clinically relevant form. Given the risks associated with taking a liver biopsy, the design of accurate non-invasive methods to identify NASH patie...

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Detalles Bibliográficos
Autores: Marañón, Patricia, Fernández-García, Carlos Ernesto, Isaza, Stephania C., Rey, Esther, Gallego-Durán, Rocío, Montero-Vallejo, Rocío, Rodríguez de Cía, Javier, Ampuero, Javier, Romero-Gómez, Manuel, García-Monzón, Carmelo, González-Rodríguez, Águeda
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/303906
Acceso en línea:http://hdl.handle.net/10261/303906
https://api.elsevier.com/content/abstract/scopus_id/85130714343
Access Level:acceso abierto
Palabra clave:Non-invasive diagnosis
BMP2
Bone morphogenetic proteins
Hepatocytes
Non-alcoholic fatty liver disease
Descripción
Sumario:Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease worldwide, being non-alcoholic steatohepatitis (NASH) its most clinically relevant form. Given the risks associated with taking a liver biopsy, the design of accurate non-invasive methods to identify NASH patients is of upmost importance. BMP2 plays a key role in metabolic homeostasis; however, little is known about its involvement in NAFLD onset and progression. This study aimed to elucidate the impact of BMP2 in NAFLD pathophysiology.

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