Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk

The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndrome in the (Prevenc...

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Detalles Bibliográficos
Autores: Papandreou C, Babio N, Díaz-López A, Martínez-González MÁ, Becerra-Tomas N, Corella D, Schröder H, Romaguera D, Alonso-Gómez ÁM, Wärnberg J, Martínez AJ, Serra-Majem L, Estruch R, Muñoz-Garach A, Lapetra J, Pintó X, Tur JA, Garcia-Rios A, Bueno-Cavanillas A, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, M Sánchez V, Vidal J, Vázquez C, Ros E, Ruiz-Canela M, Bulló M, Sorli JV, Quifer M, Colom A, Oncina-Canovas A, T Sierra L, Barón-López J, Pérez-Farinós N, Abete I, Sanchez-Villegas A, Casas R, F García JC, Santos-Lozano JM, Corbella E, Del M Bibiloni M, Diez-Espino J, Asensio EM, Torras L, Morey M, Compañ-Gabucio L, S Lete I, Cenoz-Osinaga JC, Castañer O, Salas-Salvadó J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p4501
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/4501
Access Level:acceso abierto
Palabra clave:sleep duration
actigraphy
serum uric acid
serum uric acid to creatinine ratio
Descripción
Sumario:The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndrome in the (Prevencion con Dieta Mediterranea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations ( = -0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio ( = -0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio.

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