Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation

LiYF4:Tm3+/Yb3+ upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absor...

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Authors: Yu, Q., Rodriguez, E. M., Naccache, R., Forgione, P., Lamoureux, G., Sanz Rodríguez, Francisco, Scheglmann, D., Capobianco, J. A.
Format: article
Publication Date:2014
Country:España
Institution:Universidad Autónoma de Madrid
Repository:Biblos-e Archivo. Repositorio Institucional de la UAM
Language:English
OAI Identifier:oai:repositorio.uam.es:10486/670716
Online Access:http://hdl.handle.net/10486/670716
https://dx.doi.org/10.1039/C4CC05867D
Access Level:Open access
Keyword:Benzoic acid derivative
Macrocyclic compound
Nanoparticle
Phenyl group
Porphyrin
Pyrrole derivative
Singlet oxygen
Biología y Biomedicina / Biología
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spelling Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generationYu, Q.Rodriguez, E. M.Naccache, R.Forgione, P.Lamoureux, G.Sanz Rodríguez, FranciscoScheglmann, D.Capobianco, J. A.Benzoic acid derivativeMacrocyclic compoundNanoparticlePhenyl groupPorphyrinPyrrole derivativeSinglet oxygenBiología y Biomedicina / BiologíaLiYF4:Tm3+/Yb3+ upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiationJ.A.C. is a Concordia University Research Chair in Nanoscience and is grateful to Concordia University for financial support. J.A.C., P.F., G.L. and R.N. are grateful for the support from (NSERC) Canada.The Royal Society of ChemistryDepartamento de BiologíaFacultad de Ciencias20142014-10-18research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/670716https://dx.doi.org/10.1039/C4CC05867Dreponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6707162026-06-23T12:46:27Z
dc.title.none.fl_str_mv Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation
title Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation
spellingShingle Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation
Yu, Q.
Benzoic acid derivative
Macrocyclic compound
Nanoparticle
Phenyl group
Porphyrin
Pyrrole derivative
Singlet oxygen
Biología y Biomedicina / Biología
title_short Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation
title_full Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation
title_fullStr Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation
title_full_unstemmed Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation
title_sort Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation
dc.creator.none.fl_str_mv Yu, Q.
Rodriguez, E. M.
Naccache, R.
Forgione, P.
Lamoureux, G.
Sanz Rodríguez, Francisco
Scheglmann, D.
Capobianco, J. A.
author Yu, Q.
author_facet Yu, Q.
Rodriguez, E. M.
Naccache, R.
Forgione, P.
Lamoureux, G.
Sanz Rodríguez, Francisco
Scheglmann, D.
Capobianco, J. A.
author_role author
author2 Rodriguez, E. M.
Naccache, R.
Forgione, P.
Lamoureux, G.
Sanz Rodríguez, Francisco
Scheglmann, D.
Capobianco, J. A.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Biología
Facultad de Ciencias
dc.subject.none.fl_str_mv Benzoic acid derivative
Macrocyclic compound
Nanoparticle
Phenyl group
Porphyrin
Pyrrole derivative
Singlet oxygen
Biología y Biomedicina / Biología
topic Benzoic acid derivative
Macrocyclic compound
Nanoparticle
Phenyl group
Porphyrin
Pyrrole derivative
Singlet oxygen
Biología y Biomedicina / Biología
description LiYF4:Tm3+/Yb3+ upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiation
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-10-18
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/670716
https://dx.doi.org/10.1039/C4CC05867D
url http://hdl.handle.net/10486/670716
https://dx.doi.org/10.1039/C4CC05867D
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The Royal Society of Chemistry
publisher.none.fl_str_mv The Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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