Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation

LiYF4:Tm3+/Yb3+ upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absor...

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Detalles Bibliográficos
Autores: Yu, Q., Rodriguez, E. M., Naccache, R., Forgione, P., Lamoureux, G., Sanz Rodríguez, Francisco, Scheglmann, D., Capobianco, J. A.
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/670716
Acceso en línea:http://hdl.handle.net/10486/670716
https://dx.doi.org/10.1039/C4CC05867D
Access Level:acceso abierto
Palabra clave:Benzoic acid derivative
Macrocyclic compound
Nanoparticle
Phenyl group
Porphyrin
Pyrrole derivative
Singlet oxygen
Biología y Biomedicina / Biología
Descripción
Sumario:LiYF4:Tm3+/Yb3+ upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiation

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