Nrf2 as a therapeutic target for rheumatic diseases

[EN] Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master regulator of cellular protective processes. Rheumatic diseases are chronic conditions characterized by inflammation, pain, tissue damage and limitations in function. Main examples are rheumatoid arthritis, systemic lupus erythematos...

Descripción completa

Detalles Bibliográficos
Autores: Ferrandiz Manglano, Mª Luisa, Nacher-Juan, Josep, Alcaraz Tormo, Mª Jose
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/141951
Acceso en línea:https://riunet.upv.es/handle/10251/141951
Access Level:acceso abierto
Palabra clave:Nrf2,Rheumatic conditions
Rheumatoid arthritis
Systemic lupus erythematosus
Osteoarthritis
Osteoporosis
id ES_bbd9cf3295cc7f0ea7b971797d3cbf5d
oai_identifier_str oai:riunet.upv.es:10251/141951
network_acronym_str ES
network_name_str España
repository_id_str
spelling Nrf2 as a therapeutic target for rheumatic diseasesFerrandiz Manglano, Mª LuisaNacher-Juan, JosepAlcaraz Tormo, Mª JoseNrf2,Rheumatic conditionsRheumatoid arthritisSystemic lupus erythematosusOsteoarthritisOsteoporosis[EN] Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master regulator of cellular protective processes. Rheumatic diseases are chronic conditions characterized by inflammation, pain, tissue damage and limitations in function. Main examples are rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis and osteoporosis. Their high prevalence constitutes a major health problem with an important social and economic impact. A wide range of evidence indicates that Nrf2 may control different mechanisms involved in the physiopathology of rheumatic conditions. Therefore, the appropriate expression and balance of Nrf2 is necessary for regulation of oxidative stress, inflammation, immune responses, and cartilage and bone metabolism. Numerous studies have demonstrated that Nrf2 deficiency aggravates the disease in experimental models while Nrf2 activation results in immunoregulatory and anti-inflammatory effects. These reports reinforce the increasing interest in the pharmacologic regulation of Nrf2 and its potential applications. Nevertheless, a majority of Nrf2 inducers are electrophilic molecules which may present off-target effects. In recent years, novel strategies have been sought to modulate the Nrf2 pathway which has emerged as a therapeutic target in rheumatic conditions.This work has been funded by grant SAF2017-85806-R (MINECO, FEDER, Spain).ElsevierMinisterio de Economía y CompetitividadAgencia Estatal de InvestigaciónRepositorio Institucional de la Universitat Politècnica de València Riunet20182018-06-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/141951reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 SAF2017-85806-R MECANISMOS REGULADORES DE LA INFLAMACION Y SU RESOLUCION EN ENFERMEDADES CRONICAS ARTICULARES Y DE LA PIELopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1419512026-06-13T07:49:27Z
dc.title.none.fl_str_mv Nrf2 as a therapeutic target for rheumatic diseases
title Nrf2 as a therapeutic target for rheumatic diseases
spellingShingle Nrf2 as a therapeutic target for rheumatic diseases
Ferrandiz Manglano, Mª Luisa
Nrf2,Rheumatic conditions
Rheumatoid arthritis
Systemic lupus erythematosus
Osteoarthritis
Osteoporosis
title_short Nrf2 as a therapeutic target for rheumatic diseases
title_full Nrf2 as a therapeutic target for rheumatic diseases
title_fullStr Nrf2 as a therapeutic target for rheumatic diseases
title_full_unstemmed Nrf2 as a therapeutic target for rheumatic diseases
title_sort Nrf2 as a therapeutic target for rheumatic diseases
dc.creator.none.fl_str_mv Ferrandiz Manglano, Mª Luisa
Nacher-Juan, Josep
Alcaraz Tormo, Mª Jose
author Ferrandiz Manglano, Mª Luisa
author_facet Ferrandiz Manglano, Mª Luisa
Nacher-Juan, Josep
Alcaraz Tormo, Mª Jose
author_role author
author2 Nacher-Juan, Josep
Alcaraz Tormo, Mª Jose
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad
Agencia Estatal de Investigación
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Nrf2,Rheumatic conditions
Rheumatoid arthritis
Systemic lupus erythematosus
Osteoarthritis
Osteoporosis
topic Nrf2,Rheumatic conditions
Rheumatoid arthritis
Systemic lupus erythematosus
Osteoarthritis
Osteoporosis
description [EN] Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master regulator of cellular protective processes. Rheumatic diseases are chronic conditions characterized by inflammation, pain, tissue damage and limitations in function. Main examples are rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis and osteoporosis. Their high prevalence constitutes a major health problem with an important social and economic impact. A wide range of evidence indicates that Nrf2 may control different mechanisms involved in the physiopathology of rheumatic conditions. Therefore, the appropriate expression and balance of Nrf2 is necessary for regulation of oxidative stress, inflammation, immune responses, and cartilage and bone metabolism. Numerous studies have demonstrated that Nrf2 deficiency aggravates the disease in experimental models while Nrf2 activation results in immunoregulatory and anti-inflammatory effects. These reports reinforce the increasing interest in the pharmacologic regulation of Nrf2 and its potential applications. Nevertheless, a majority of Nrf2 inducers are electrophilic molecules which may present off-target effects. In recent years, novel strategies have been sought to modulate the Nrf2 pathway which has emerged as a therapeutic target in rheumatic conditions.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-06-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/141951
url https://riunet.upv.es/handle/10251/141951
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 SAF2017-85806-R MECANISMOS REGULADORES DE LA INFLAMACION Y SU RESOLUCION EN ENFERMEDADES CRONICAS ARTICULARES Y DE LA PIEL
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418061594886144
score 15.301603

Similares en LA Referencia