Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes

Carbonell, Marc; Castelblanco Echavarría, Esmeralda; Valldeperas, Xavier; Betriu i Bars, M. Àngels; Traveset Maeso, Alicia; Granado Casas, Minerva; Hernández García, Marta; Vázquez, Federico; Martín, Mariona; Rubinat, Esther; Lecube Torelló, Albert; Franch-Nadal, Josep; Fernández i Giráldez, Elvira; Puig-Domingo, Manuel; Avogaro, Angelo; Alonso, Núria; Mauricio Puente, Dídac

Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes

Background: Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the association of the frequency and the burden of subclinical carotid atherosclerotic dise...

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Autores:	Carbonell, Marc, Castelblanco Echavarría, Esmeralda, Valldeperas, Xavier, Betriu i Bars, M. Àngels, Traveset Maeso, Alicia, Granado Casas, Minerva, Hernández García, Marta, Vázquez, Federico, Martín, Mariona, Rubinat, Esther, Lecube Torelló, Albert, Franch-Nadal, Josep, Fernández i Giráldez, Elvira, Puig-Domingo, Manuel, Avogaro, Angelo, Alonso, Núria, Mauricio Puente, Dídac
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2018
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:10459.1/63260
Acceso en línea:	https://doi.org/10.1186/s12933-018-0706-z http://hdl.handle.net/10459.1/63260
Access Level:	acceso abierto
Palabra clave:	Diabetis Retinopatia diabètica Aterosclerosi Diabetes Diabetic retinopathy Atherosclerosis

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spelling	Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetesCarbonell, MarcCastelblanco Echavarría, EsmeraldaValldeperas, XavierBetriu i Bars, M. ÀngelsTraveset Maeso, AliciaGranado Casas, MinervaHernández García, MartaVázquez, FedericoMartín, MarionaRubinat, EstherLecube Torelló, AlbertFranch-Nadal, JosepFernández i Giráldez, ElviraPuig-Domingo, ManuelAvogaro, AngeloAlonso, NúriaMauricio Puente, DídacDiabetisRetinopatia diabèticaAterosclerosiDiabetesDiabetic retinopathyAtherosclerosisBackground: Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the association of the frequency and the burden of subclinical carotid atherosclerotic disease in patients with type 1 diabetes according to the presence and severity of diabetic retinopathy (DR). Methods: A cross-sectional study was conducted in 340 patients with type 1 diabetes (41.5% with DR), and in 304 non-diabetic individuals. All participants were free from previous CV disease and chronic kidney disease (CKD). B-mode carotid ultrasound imaging was performed in all the study subjects. Patients with type 1 diabetes underwent a full eye examination, and DR patients were divided into two groups: mild disease and advanced disease. Results: In the group of patients with type 1 diabetes, the percentage of patients with carotid plaques was higher in those with DR compared with those without DR (44.7% vs. 24.1%, p < 0.001). Patients with DR also presented a higher incidence of ≥ 2 carotid plaques (25.5% vs. 11.1%, p < 0.001). Apart from other traditional cardiovascular risk factors, the presence of advanced stages of DR was independently associated with the presence (p = 0.044) and the burden (≥ 2 carotid plaques; p = 0.009) of subclinical carotid atherosclerosis. Conclusions: In patients with type 1 diabetes without previous CV disease or established CKD, the presence of advanced stages of DR is associated with a higher atherosclerotic burden in the carotid arteries. The presence of DR identifies patients at risk for carotid atherosclerotic disease.This research was supported by grants from the Spanish Ministry of Health, the Carlos III National Institute of Health (PI12/0183 and PI15/0625) and European Regional Development Fund (ERDF). CIBER for Diabetes and Associated Metabolic Diseases (CIBERDEM) is an initiative of ISCIII, Spain.BioMed Central2018201820182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1186/s12933-018-0706-zhttp://hdl.handle.net/10459.1/63260http://hdl.handle.net/10459.1/63260reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s12933-018-0706-zCardiovascular Diabetology, 2018, vol. 17, núm. 66, p. 1-10cc-by (c) Carbonell, Marc et al., 2018info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/esoai:recercat.cat:10459.1/632602026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes
title	Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes
spellingShingle	Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes Carbonell, Marc Diabetis Retinopatia diabètica Aterosclerosi Diabetes Diabetic retinopathy Atherosclerosis
title_short	Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes
title_full	Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes
title_fullStr	Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes
title_full_unstemmed	Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes
title_sort	Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes
dc.creator.none.fl_str_mv	Carbonell, Marc Castelblanco Echavarría, Esmeralda Valldeperas, Xavier Betriu i Bars, M. Àngels Traveset Maeso, Alicia Granado Casas, Minerva Hernández García, Marta Vázquez, Federico Martín, Mariona Rubinat, Esther Lecube Torelló, Albert Franch-Nadal, Josep Fernández i Giráldez, Elvira Puig-Domingo, Manuel Avogaro, Angelo Alonso, Núria Mauricio Puente, Dídac
author	Carbonell, Marc
author_facet	Carbonell, Marc Castelblanco Echavarría, Esmeralda Valldeperas, Xavier Betriu i Bars, M. Àngels Traveset Maeso, Alicia Granado Casas, Minerva Hernández García, Marta Vázquez, Federico Martín, Mariona Rubinat, Esther Lecube Torelló, Albert Franch-Nadal, Josep Fernández i Giráldez, Elvira Puig-Domingo, Manuel Avogaro, Angelo Alonso, Núria Mauricio Puente, Dídac
author_role	author
author2	Castelblanco Echavarría, Esmeralda Valldeperas, Xavier Betriu i Bars, M. Àngels Traveset Maeso, Alicia Granado Casas, Minerva Hernández García, Marta Vázquez, Federico Martín, Mariona Rubinat, Esther Lecube Torelló, Albert Franch-Nadal, Josep Fernández i Giráldez, Elvira Puig-Domingo, Manuel Avogaro, Angelo Alonso, Núria Mauricio Puente, Dídac
author2_role	author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Diabetis Retinopatia diabètica Aterosclerosi Diabetes Diabetic retinopathy Atherosclerosis
topic	Diabetis Retinopatia diabètica Aterosclerosi Diabetes Diabetic retinopathy Atherosclerosis
description	Background: Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the association of the frequency and the burden of subclinical carotid atherosclerotic disease in patients with type 1 diabetes according to the presence and severity of diabetic retinopathy (DR). Methods: A cross-sectional study was conducted in 340 patients with type 1 diabetes (41.5% with DR), and in 304 non-diabetic individuals. All participants were free from previous CV disease and chronic kidney disease (CKD). B-mode carotid ultrasound imaging was performed in all the study subjects. Patients with type 1 diabetes underwent a full eye examination, and DR patients were divided into two groups: mild disease and advanced disease. Results: In the group of patients with type 1 diabetes, the percentage of patients with carotid plaques was higher in those with DR compared with those without DR (44.7% vs. 24.1%, p < 0.001). Patients with DR also presented a higher incidence of ≥ 2 carotid plaques (25.5% vs. 11.1%, p < 0.001). Apart from other traditional cardiovascular risk factors, the presence of advanced stages of DR was independently associated with the presence (p = 0.044) and the burden (≥ 2 carotid plaques; p = 0.009) of subclinical carotid atherosclerosis. Conclusions: In patients with type 1 diabetes without previous CV disease or established CKD, the presence of advanced stages of DR is associated with a higher atherosclerotic burden in the carotid arteries. The presence of DR identifies patients at risk for carotid atherosclerotic disease.
publishDate	2018
dc.date.none.fl_str_mv	2018 2018 2018 2018
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://doi.org/10.1186/s12933-018-0706-z http://hdl.handle.net/10459.1/63260 http://hdl.handle.net/10459.1/63260
url	https://doi.org/10.1186/s12933-018-0706-z http://hdl.handle.net/10459.1/63260
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1186/s12933-018-0706-z Cardiovascular Diabetology, 2018, vol. 17, núm. 66, p. 1-10
dc.rights.none.fl_str_mv	cc-by (c) Carbonell, Marc et al., 2018 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/3.0/es
rights_invalid_str_mv	cc-by (c) Carbonell, Marc et al., 2018 http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	BioMed Central
publisher.none.fl_str_mv	BioMed Central
dc.source.none.fl_str_mv	reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
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Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes

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