Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes

Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the association of the frequency and the burden of subclinical carotid atherosclerotic disease in patie...

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Authors: Carbonell Puig, Marc, Castelblanco, Esmeralda|||0000-0002-2061-6270, Valldeperas Belmonte, Xavier|||0000-0002-6343-6405, Betriu, Àngels|||0000-0002-0290-4586, Traveset, Alicia|||0000-0003-2703-326X, Granado-Casas, Minerva|||0000-0003-3447-5728, Hernández García, Marta|||0000-0003-1237-298X, Vázquez, Federico|||0000-0001-6493-2374, Martín, Mariona, Rubinat, Esther|||0000-0003-0232-9777, Lecube, Albert|||0000-0001-9684-0183, Franch-Nadal, Josep|||0000-0002-5175-1555, Fernández, Elvira|||0000-0001-5236-1762, Puig Domingo, Manuel|||0000-0002-6744-7195, Avogaro, Angelo, Alonso Pedrol, Núria|||0000-0001-9687-8050, Mauricio, Didac|||0000-0002-2868-0250
Format: article
Publication Date:2018
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:253520
Online Access:https://ddd.uab.cat/record/253520
https://dx.doi.org/urn:doi:10.1186/s12933-018-0706-z
Access Level:Open access
Keyword:Type 1 diabetes
Retinopathy
Subclinical carotid atherosclerosis
Description
Summary:Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the association of the frequency and the burden of subclinical carotid atherosclerotic disease in patients with type 1 diabetes according to the presence and severity of diabetic retinopathy (DR). A cross-sectional study was conducted in 340 patients with type 1 diabetes (41.5% with DR), and in 304 non-diabetic individuals. All participants were free from previous CV disease and chronic kidney disease (CKD). B-mode carotid ultrasound imaging was performed in all the study subjects. Patients with type 1 diabetes underwent a full eye examination, and DR patients were divided into two groups: mild disease and advanced disease. In the group of patients with type 1 diabetes, the percentage of patients with carotid plaques was higher in those with DR compared with those without DR (44.7% vs. 24.1%, p < 0.001). Patients with DR also presented a higher incidence of ≥ 2 carotid plaques (25.5% vs. 11.1%, p < 0.001). Apart from other traditional cardiovascular risk factors, the presence of advanced stages of DR was independently associated with the presence (p = 0.044) and the burden (≥ 2 carotid plaques; p = 0.009) of subclinical carotid atherosclerosis. In patients with type 1 diabetes without previous CV disease or established CKD, the presence of advanced stages of DR is associated with a higher atherosclerotic burden in the carotid arteries. The presence of DR identifies patients at risk for carotid atherosclerotic disease.

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