Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis

Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response...

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Detalles Bibliográficos
Autores: Brune-Ingebretsen, Synne, Høgestøl, Einar A., de Rosbo, Nicole Kerlero, Berg-Hansen, Pål, Brunborg, Cathrine, Blennow, Kaj, Zetterberg, Henrik, Paul, Friedemann, Uccelli, Antonio, Villoslada, Pablo, Harbo, Hanne F., Berge, Tone
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/70235
Acceso en línea:http://hdl.handle.net/10230/70235
http://dx.doi.org/10.1016/j.jneuroim.2023.578175
Access Level:acceso abierto
Palabra clave:Multiple sclerosis
Serum neurofilament light chain
Immune cell subset frequencies
Biomarkers
Disease worsening
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spelling Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosisBrune-Ingebretsen, SynneHøgestøl, Einar A.de Rosbo, Nicole KerleroBerg-Hansen, PålBrunborg, CathrineBlennow, KajZetterberg, HenrikPaul, FriedemannUccelli, AntonioVilloslada, PabloHarbo, Hanne F.Berge, ToneMultiple sclerosisSerum neurofilament light chainImmune cell subset frequenciesBiomarkersDisease worseningChanges is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS.This work was supported by the European Commission (ERACOSYSMED ERA-Net program, Sys4MS project, id:43), Instituto de Salud Carlos III, Spain (AC1500052), the Italian Ministry of Health (WFR-PER-2013-02361136), the German Ministry of Science (Deutsches Teilprojekt B “Förderkennzeichen”: 031L0083B), the Norwegian Research Council (project 257955), the South-Eastern Norway Regional Health Authority (project 2019111) and Biogen Norway. Henrik Zetterberg is a Wallenberg Scholar supported by grants from the Swedish Research Council (#2022-01018), the European Union's Horizon Europe research and innovation programme under grant agreement No 101053962, and Swedish State Support for Clinical Research (#ALFGBG-71320).Elsevier202520252023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/70235http://dx.doi.org/10.1016/j.jneuroim.2023.578175http://hdl.handle.net/10230/70235reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Neuroimmunology. 2023 Sep;382:578175info:eu-repo/grantAgreement/EC/H2020/101053962© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/702352026-05-29T05:05:01Z
dc.title.none.fl_str_mv Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
title Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
spellingShingle Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
Brune-Ingebretsen, Synne
Multiple sclerosis
Serum neurofilament light chain
Immune cell subset frequencies
Biomarkers
Disease worsening
title_short Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
title_full Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
title_fullStr Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
title_full_unstemmed Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
title_sort Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
dc.creator.none.fl_str_mv Brune-Ingebretsen, Synne
Høgestøl, Einar A.
de Rosbo, Nicole Kerlero
Berg-Hansen, Pål
Brunborg, Cathrine
Blennow, Kaj
Zetterberg, Henrik
Paul, Friedemann
Uccelli, Antonio
Villoslada, Pablo
Harbo, Hanne F.
Berge, Tone
author Brune-Ingebretsen, Synne
author_facet Brune-Ingebretsen, Synne
Høgestøl, Einar A.
de Rosbo, Nicole Kerlero
Berg-Hansen, Pål
Brunborg, Cathrine
Blennow, Kaj
Zetterberg, Henrik
Paul, Friedemann
Uccelli, Antonio
Villoslada, Pablo
Harbo, Hanne F.
Berge, Tone
author_role author
author2 Høgestøl, Einar A.
de Rosbo, Nicole Kerlero
Berg-Hansen, Pål
Brunborg, Cathrine
Blennow, Kaj
Zetterberg, Henrik
Paul, Friedemann
Uccelli, Antonio
Villoslada, Pablo
Harbo, Hanne F.
Berge, Tone
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Multiple sclerosis
Serum neurofilament light chain
Immune cell subset frequencies
Biomarkers
Disease worsening
topic Multiple sclerosis
Serum neurofilament light chain
Immune cell subset frequencies
Biomarkers
Disease worsening
description Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/70235
http://dx.doi.org/10.1016/j.jneuroim.2023.578175
http://hdl.handle.net/10230/70235
url http://hdl.handle.net/10230/70235
http://dx.doi.org/10.1016/j.jneuroim.2023.578175
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Neuroimmunology. 2023 Sep;382:578175
info:eu-repo/grantAgreement/EC/H2020/101053962
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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