Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis

Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response...

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Bibliographic Details
Authors: Brune-Ingebretsen, Synne, Høgestøl, Einar A., de Rosbo, Nicole Kerlero, Berg-Hansen, Pål, Brunborg, Cathrine, Blennow, Kaj, Zetterberg, Henrik, Paul, Friedemann, Uccelli, Antonio, Villoslada, Pablo, Harbo, Hanne F., Berge, Tone
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/70235
Online Access:http://hdl.handle.net/10230/70235
http://dx.doi.org/10.1016/j.jneuroim.2023.578175
Access Level:Open access
Keyword:Multiple sclerosis
Serum neurofilament light chain
Immune cell subset frequencies
Biomarkers
Disease worsening
Description
Summary:Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS.

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