Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status

The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. H...

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Autores: Khoury, Nadine, Martínez, María Ángeles, Paz-Graniel, Indira, Martínez-González, Miguel Ángel, Corella, Dolores, Castañer-Niño, Olga, Martínez, J Alfredo, Alonso-Gomez, Angel M., Wärnberg, Julia, Vioque, Jesus, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Lapetra, José, Serra-Majem, Lluis, Bueno-Cavanillas, Aurora, Tur, Josep A., Sanjurjo, Sergio Cinza, Pintó, Xavier, Gaforio, José Juan, Matía-Martín, Pilar, Vidal, Josep, Vazquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Sayon-Orea, Carmen, Sorli, Jose V., Pérez-Vega, Karla-Alejandra, Garcia-Rios, Antonio, Gómez Bellvert, Nuria, Gómez-Gracia, Enrique, Zulet, M A, Chaplin, Alice, Casas, Rosa, Salcedo-Bellido, Inmaculada, Tojal-Sierra, Lucas, Rosa Bernal-Lopez, Maria, Vazquez-Ruiz, Zenaida, Asensio, Eva M, Goday, Albert, Peña-Orihuela, Patricia Judith, Signes-Pastor, Antonio J, Garcia-Arellano, Ana, Fito, Montserrat, Babio, Nancy, Salas-Salvado, Jordi
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/18975
Acceso en línea:https://hdl.handle.net/20.500.13003/18975
Access Level:acceso abierto
Palabra clave:Dioxins
Humans
Eating
Middle Aged
Cross-Sectional Studies
Furans
Male
Prospective Studies
Female
Adiposity
Dibenzofurans, Polychlorinated
Dibenzofurans
Polychlorinated Dibenzodioxins
Overweight
Polychlorinated Biphenyls
Obesity, Abdominal
Femenino
Dibenzofuranos Policlorados
Dibenzodioxinas Policloradas
Dibenzofuranos
Masculino
Dioxinas
Furanos
Obesidad Abdominal
Estudios Transversales
Persona de Mediana Edad
Humanos
Estudios Prospectivos
Ingestión de Alimentos
Bifenilos Policlorados
Sobrepeso
Adiposidad
Descripción
Sumario:The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited. To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population. In 5899 participants aged 55-75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models. Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumference (1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05 [1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, participants in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in the first tertile after 1-year of follow-up (β-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015). Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at baseline and with changes in waist circumference after 1-year of follow-up in subjects living with overweight/obesity. Further large prospective studies using a different population with longer follow-up periods are warranted in the future to strengthen our results.

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