Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status.

Introduction: The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and h...

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Detalhes bibliográficos
Autores: Khoury, N., Martínez, M.Á., Paz-Graniel, I., Martínez-González, M.Á., Corella, D., Castañer, O., Martínez, J.A., Alonso-Gómez, Á.M., Wärnberg, J., Vioque, J., Romaguera, D., López-Miranda, J., Estruch, R., Tinahones, F.J., Lapetra, J., Serra-Majem, J.L., Bueno-Cavanillas, A., Tur, J.A., Cinza Sanjurjo, Sergio, Pintó, X., Gaforio, J.J., Matía-Martín, P., Vidal, J., Vázquez, C., Daimiel, L., Ros, E., Sayon-Orea, C., Sorlí, J.V., Pérez-Vega, K.-A., Garcia-Rios, A., Bellvert, N.G., Gómez-Gracia, E., Zulet, M.A., Chaplin, A., Casas, R., Salcedo-Bellido, I., Tojal-Sierra, L., Bernal-Lopez, M.-R., Vázquez-Ruiz, Z., Asensio, E.M., Goday, A., Peña-Orihuela, P.J., Signes-Pastor, A.J., Garcia-Arellano, A., Fitó, M., Babio, N., Salas-Salvadó, J.
Tipo de documento: artigo
Data de publicação:2023
País:España
Recursos:Servizo Galego de Saúde (SERGAS)
Repositório:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21347
Acesso em linha:https://portalcientifico.sergas.gal//documentos/6433d259e8f2fa0e62f2b253
http://hdl.handle.net/20.500.11940/21347
Access Level:Acceso aberto
Palavra-chave:Middle Aged
Humans
Female
Male
Polychlorinated Dibenzodioxins
Dibenzofurans
Dioxins
Adiposity
Furans
Overweight
Obesity, Abdominal
Cross-Sectional Studies
Prospective Studies
Dibenzofurans, Polychlorinated
Eating
Polychlorinated Biphenyls
AS Santiago
AS Santiago AP
Descrição
Resumo:Introduction: The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited. Objective: To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population. Methods: In 5899 participants aged 55-75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models. Results: Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (?-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumference (1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05 [1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, participants in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in the first tertile after 1-year of follow-up (?-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015). Conclusion: Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at baseline and with changes in waist circumference after 1-year of follow-up in subjects living with overweight/obesity. Further large prospective studies using a different population with longer follow-up periods are warranted in the future to strengthen our results.

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