Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change

Organismal ageing is associated with many physiological changes, including differences in the immune system of most animals. These differences are often considered to be a key cause of age-associated diseases as well as decreased vaccine responses in humans. The most often cited vaccine failure is s...

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Autores: Fülöp, T., Larbi, A., Pawelec, G., Cohen, A., Provost, G., Khalil, A., Lacombe, G., Rodrigues, S., Desroches, M., Hirokawa, K., Franceschi, C., Witkowski, J.M.
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2022
País:España
Recursos:Basque Center for Applied Mathematics (BCAM)
Repositório:BIRD. BCAM's Institutional Repository Data
OAI Identifier:oai:bird.bcamath.org:20.500.11824/1492
Acesso em linha:http://hdl.handle.net/20.500.11824/1492
Access Level:Acceso aberto
Palavra-chave:adaptive complex systems
COVID-19 vaccine
herpes–zoster vaccine
immunobiography
immunosenescence
inflammaging
influenza vaccine
mathematical model
pneumococcal vaccine
tipping point
trained immunity
vaccination
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spelling Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to ChangeFülöp, T.Larbi, A.Pawelec, G.Cohen, A.Provost, G.Khalil, A.Lacombe, G.Rodrigues, S.Desroches, M.Hirokawa, K.Franceschi, C.Witkowski, J.M.adaptive complex systemsCOVID-19 vaccineherpes–zoster vaccineimmunobiographyimmunosenescenceinflammaginginfluenza vaccinemathematical modelpneumococcal vaccinetipping pointtrained immunityvaccinationOrganismal ageing is associated with many physiological changes, including differences in the immune system of most animals. These differences are often considered to be a key cause of age-associated diseases as well as decreased vaccine responses in humans. The most often cited vaccine failure is seasonal influenza, but, while it is usually the case that the efficiency of this vaccine is lower in older than younger adults, this is not always true, and the reasons for the differential responses are manifold. Undoubtedly, changes in the innate and adaptive immune response with ageing are associated with failure to respond to the influenza vaccine, but the cause is unclear. Moreover, recent advances in vaccine formulations and adjuvants, as well as in our understanding of immune changes with ageing, have contributed to the development of vaccines, such as those against herpes zoster and SARS-CoV-2, that can protect against serious disease in older adults just as well as in younger people. In the present article, we discuss the reasons why it is a myth that vaccines inevitably protect less well in older individuals, and that vaccines represent one of the most powerful means to protect the health and ensure the quality of life of older adults.Inria Associated Team "NeuroTransSF"202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/20.500.11824/1492reponame:BIRD. BCAM's Institutional Repository Datainstname:Basque Center for Applied Mathematics (BCAM)Ingléshttps://www.mdpi.com/2076-393X/10/4/607info:eu-repo/grantAgreement/MINECO//SEV-2017-0718info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-093860-B-C21info:eu-repo/grantAgreement/Gobierno Vasco/BERC/BERC.2018-2021Reconocimiento-NoComercial-CompartirIgual 3.0 Españahttp://creativecommons.org/licenses/by-nc-sa/3.0/es/info:eu-repo/semantics/openAccessoai:bird.bcamath.org:20.500.11824/14922026-06-19T12:47:47Z
dc.title.none.fl_str_mv Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change
title Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change
spellingShingle Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change
Fülöp, T.
adaptive complex systems
COVID-19 vaccine
herpes–zoster vaccine
immunobiography
immunosenescence
inflammaging
influenza vaccine
mathematical model
pneumococcal vaccine
tipping point
trained immunity
vaccination
title_short Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change
title_full Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change
title_fullStr Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change
title_full_unstemmed Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change
title_sort Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change
dc.creator.none.fl_str_mv Fülöp, T.
Larbi, A.
Pawelec, G.
Cohen, A.
Provost, G.
Khalil, A.
Lacombe, G.
Rodrigues, S.
Desroches, M.
Hirokawa, K.
Franceschi, C.
Witkowski, J.M.
author Fülöp, T.
author_facet Fülöp, T.
Larbi, A.
Pawelec, G.
Cohen, A.
Provost, G.
Khalil, A.
Lacombe, G.
Rodrigues, S.
Desroches, M.
Hirokawa, K.
Franceschi, C.
Witkowski, J.M.
author_role author
author2 Larbi, A.
Pawelec, G.
Cohen, A.
Provost, G.
Khalil, A.
Lacombe, G.
Rodrigues, S.
Desroches, M.
Hirokawa, K.
Franceschi, C.
Witkowski, J.M.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv adaptive complex systems
COVID-19 vaccine
herpes–zoster vaccine
immunobiography
immunosenescence
inflammaging
influenza vaccine
mathematical model
pneumococcal vaccine
tipping point
trained immunity
vaccination
topic adaptive complex systems
COVID-19 vaccine
herpes–zoster vaccine
immunobiography
immunosenescence
inflammaging
influenza vaccine
mathematical model
pneumococcal vaccine
tipping point
trained immunity
vaccination
description Organismal ageing is associated with many physiological changes, including differences in the immune system of most animals. These differences are often considered to be a key cause of age-associated diseases as well as decreased vaccine responses in humans. The most often cited vaccine failure is seasonal influenza, but, while it is usually the case that the efficiency of this vaccine is lower in older than younger adults, this is not always true, and the reasons for the differential responses are manifold. Undoubtedly, changes in the innate and adaptive immune response with ageing are associated with failure to respond to the influenza vaccine, but the cause is unclear. Moreover, recent advances in vaccine formulations and adjuvants, as well as in our understanding of immune changes with ageing, have contributed to the development of vaccines, such as those against herpes zoster and SARS-CoV-2, that can protect against serious disease in older adults just as well as in younger people. In the present article, we discuss the reasons why it is a myth that vaccines inevitably protect less well in older individuals, and that vaccines represent one of the most powerful means to protect the health and ensure the quality of life of older adults.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.11824/1492
url http://hdl.handle.net/20.500.11824/1492
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/2076-393X/10/4/607
info:eu-repo/grantAgreement/MINECO//SEV-2017-0718
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-093860-B-C21
info:eu-repo/grantAgreement/Gobierno Vasco/BERC/BERC.2018-2021
dc.rights.none.fl_str_mv Reconocimiento-NoComercial-CompartirIgual 3.0 España
http://creativecommons.org/licenses/by-nc-sa/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reconocimiento-NoComercial-CompartirIgual 3.0 España
http://creativecommons.org/licenses/by-nc-sa/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:BIRD. BCAM's Institutional Repository Data
instname:Basque Center for Applied Mathematics (BCAM)
instname_str Basque Center for Applied Mathematics (BCAM)
reponame_str BIRD. BCAM's Institutional Repository Data
collection BIRD. BCAM's Institutional Repository Data
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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