Effects of exercise interventions to reduce chemotherapy-induced peripheral neuropathy severity: A meta-analysis

Objectives The two aims of this systematic review and meta-analysis were to (1) analyze the effect of exercise on chemotherapy-induced peripheral neuropathy (CIPN) severity and (2) determine the best type of exercise for the management of CIPN. Methods We systematically searched the MEDLINE, WOS, Sp...

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Autores: Núñez de Arenas Arroyo, Sergio, Cavero Redondo, Iván, Torres Costoso, Ana Isabel, Reina Gutiérrez, Sara, Lorenzo García, Patricia, Martínez Vizcaíno, Vicente José Anastasio
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/36916
Acceso en línea:https://doi.org/10.1111/sms.14360
https://hdl.handle.net/10578/36916
Access Level:acceso abierto
Palabra clave:Cancer
Chemotherapy-induced peripheral neuropathy
Exercise
Meta-analysis
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spelling Effects of exercise interventions to reduce chemotherapy-induced peripheral neuropathy severity: A meta-analysisNúñez de Arenas Arroyo, SergioCavero Redondo, IvánTorres Costoso, Ana IsabelReina Gutiérrez, SaraLorenzo García, PatriciaMartínez Vizcaíno, Vicente José AnastasioCancerChemotherapy-induced peripheral neuropathyExerciseMeta-analysisObjectives The two aims of this systematic review and meta-analysis were to (1) analyze the effect of exercise on chemotherapy-induced peripheral neuropathy (CIPN) severity and (2) determine the best type of exercise for the management of CIPN. Methods We systematically searched the MEDLINE, WOS, Sportdiscus, Scopus, and Cochrane databases from inception to December 2020 for experimental studies addressing the effect of exercise on CIPN severity, as measured by symptom severity (SSS) and peripheral deep sensitivity (PDS). The DerSimonian and Laird method was used to compute pooled estimates of the standardized mean differences (SMDs) and its respective 95% confidence intervals (CIs). Subgroup analyses were performed based on the types of exercise and the frequency and length of the interventions. Results Thirteen studies were included in this meta-analysis. In the analyses comparing exercise interventions versus controls, there was an improvement in the SSS (SMD = −0.21; 95% CI: −0.40 to −0.01; %change: −20.34%) and the PDS (SMD = 0.49; 95% CI: 0.06 to 0.91; %change: 31.64%) in favor of the intervention group. In the pre–post analyses, there was an improvement in the SSS (SMD = −0.72; 95% CI: −1.10 to −0.34; %change: −15.65%) and the PDS (SMD = 0.47; 95% CI: 0.15 to 0.79; %change:18.98%). Conclusions This meta-analysis provides an overview of the evidence supporting exercise as a suitable intervention to reduce the severity of CIPN by reducing the severity of the symptoms and the peripheral deep sensitivity among patients with cancer or cancer survivors. Furthermore, sensoriomotor training and mind–body exercises appear to be more effective in reducing symptom severity, and active nerve-specific exercises and mind–body exercises seem to be more effective in improving peripheral deep sensitivity.John Wiley & Sons202420242023info:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1111/sms.14360https://hdl.handle.net/10578/36916reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésSNA- A (2020-PREDUCLM-16704)SR- G (2020-PREDUCLM-15596)info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/oai:ruidera.uclm.es:10578/369162026-05-27T07:36:41Z
dc.title.none.fl_str_mv Effects of exercise interventions to reduce chemotherapy-induced peripheral neuropathy severity: A meta-analysis
title Effects of exercise interventions to reduce chemotherapy-induced peripheral neuropathy severity: A meta-analysis
spellingShingle Effects of exercise interventions to reduce chemotherapy-induced peripheral neuropathy severity: A meta-analysis
Núñez de Arenas Arroyo, Sergio
Cancer
Chemotherapy-induced peripheral neuropathy
Exercise
Meta-analysis
title_short Effects of exercise interventions to reduce chemotherapy-induced peripheral neuropathy severity: A meta-analysis
title_full Effects of exercise interventions to reduce chemotherapy-induced peripheral neuropathy severity: A meta-analysis
title_fullStr Effects of exercise interventions to reduce chemotherapy-induced peripheral neuropathy severity: A meta-analysis
title_full_unstemmed Effects of exercise interventions to reduce chemotherapy-induced peripheral neuropathy severity: A meta-analysis
title_sort Effects of exercise interventions to reduce chemotherapy-induced peripheral neuropathy severity: A meta-analysis
dc.creator.none.fl_str_mv Núñez de Arenas Arroyo, Sergio
Cavero Redondo, Iván
Torres Costoso, Ana Isabel
Reina Gutiérrez, Sara
Lorenzo García, Patricia
Martínez Vizcaíno, Vicente José Anastasio
author Núñez de Arenas Arroyo, Sergio
author_facet Núñez de Arenas Arroyo, Sergio
Cavero Redondo, Iván
Torres Costoso, Ana Isabel
Reina Gutiérrez, Sara
Lorenzo García, Patricia
Martínez Vizcaíno, Vicente José Anastasio
author_role author
author2 Cavero Redondo, Iván
Torres Costoso, Ana Isabel
Reina Gutiérrez, Sara
Lorenzo García, Patricia
Martínez Vizcaíno, Vicente José Anastasio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Cancer
Chemotherapy-induced peripheral neuropathy
Exercise
Meta-analysis
topic Cancer
Chemotherapy-induced peripheral neuropathy
Exercise
Meta-analysis
description Objectives The two aims of this systematic review and meta-analysis were to (1) analyze the effect of exercise on chemotherapy-induced peripheral neuropathy (CIPN) severity and (2) determine the best type of exercise for the management of CIPN. Methods We systematically searched the MEDLINE, WOS, Sportdiscus, Scopus, and Cochrane databases from inception to December 2020 for experimental studies addressing the effect of exercise on CIPN severity, as measured by symptom severity (SSS) and peripheral deep sensitivity (PDS). The DerSimonian and Laird method was used to compute pooled estimates of the standardized mean differences (SMDs) and its respective 95% confidence intervals (CIs). Subgroup analyses were performed based on the types of exercise and the frequency and length of the interventions. Results Thirteen studies were included in this meta-analysis. In the analyses comparing exercise interventions versus controls, there was an improvement in the SSS (SMD = −0.21; 95% CI: −0.40 to −0.01; %change: −20.34%) and the PDS (SMD = 0.49; 95% CI: 0.06 to 0.91; %change: 31.64%) in favor of the intervention group. In the pre–post analyses, there was an improvement in the SSS (SMD = −0.72; 95% CI: −1.10 to −0.34; %change: −15.65%) and the PDS (SMD = 0.47; 95% CI: 0.15 to 0.79; %change:18.98%). Conclusions This meta-analysis provides an overview of the evidence supporting exercise as a suitable intervention to reduce the severity of CIPN by reducing the severity of the symptoms and the peripheral deep sensitivity among patients with cancer or cancer survivors. Furthermore, sensoriomotor training and mind–body exercises appear to be more effective in reducing symptom severity, and active nerve-specific exercises and mind–body exercises seem to be more effective in improving peripheral deep sensitivity.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://doi.org/10.1111/sms.14360
https://hdl.handle.net/10578/36916
url https://doi.org/10.1111/sms.14360
https://hdl.handle.net/10578/36916
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv SNA- A (2020-PREDUCLM-16704)
SR- G (2020-PREDUCLM-15596)
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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