Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status

There is limited evidence of phenolic compounds acting as protective agents on several cancer types, including breast cancer (BC). Nevertheless, some polyphenol classes have not been investigated and there is a lack of studies assessing the effect on menopausal status and hormone receptor status as...

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Autores: Vitelli Storelli, Facundo, Zamora-Ros, Raul, Molina de la Torre, Antonio José, Fernández Villa, Tania, Castelló, Adela, Barrio, Juan Pablo, Amiano, Pilar, Ardanaz, Eva, Obón Santacana, Mireia, Gómez Acebo, Inés, Fernández Tardón, Guillermo, Molina Barceló, Ana, Alguacil, Juan, Marcos Gragera, Rafael, Ruiz Moreno, Emma, Pedraza, Manuela, Gil, Leire, Guevara, Marcela, Castaño-Vinyals, Gemma, Dierssen Sotos, Trinidad, Kogevinas, Manolis, Aragonès Sanz, Núria, Martín Sánchez, Vicente
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/173027
Acceso en línea:https://hdl.handle.net/2445/173027
Access Level:acceso abierto
Palabra clave:Càncer de mama
Flavonoides
Polifenols
Breast cancer
Flavonoids
Polyphenols
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spelling Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor StatusVitelli Storelli, FacundoZamora-Ros, RaulMolina de la Torre, Antonio JoséFernández Villa, TaniaCastelló, AdelaBarrio, Juan PabloAmiano, PilarArdanaz, EvaObón Santacana, MireiaGómez Acebo, InésFernández Tardón, GuillermoMolina Barceló, AnaAlguacil, JuanMarcos Gragera, RafaelRuiz Moreno, EmmaPedraza, ManuelaGil, LeireGuevara, MarcelaCastaño-Vinyals, GemmaDierssen Sotos, TrinidadKogevinas, ManolisAragonès Sanz, NúriaMartín Sánchez, VicenteCàncer de mamaFlavonoidesPolifenolsBreast cancerFlavonoidsPolyphenolsThere is limited evidence of phenolic compounds acting as protective agents on several cancer types, including breast cancer (BC). Nevertheless, some polyphenol classes have not been investigated and there is a lack of studies assessing the effect on menopausal status and hormone receptor status as influenced by these compounds. The objective of this study is to evaluate the association between the intake of all polyphenol classes in relation to the BC risk by menopausal and hormone receptor status. We used data from a population-based multi-case-control study (MCC-Spain) including 1472 BC cases and 1577 controls from 12 different regions of Spain. The odds ratios (ORs) with 95% CI were calculated using logistic regression of mixed effects by quartiles and log2 of polyphenol intakes (adjusted for the residual method) of overall BC, menopausal and receptor status. No associations were found between total intake of polyphenols and BC risk. However, inverse associations were found between stilbenes and all BC risk (ORQ4 vs. Q1: 0.70, 95%CI: 0.56-0.89, P-trend = 0.001), the consumption of hydroxybenzaldehydes (ORQ4 vs. Q1: 0.75, 95%CI: 0.59-0.93, P-trend = 0.012) and hydroxycoumarins (ORQ4 vs. Q1: 0.73, 95%CI: 0.57-0.93; P-trend = 0.005) were also inversely associated. The intake of stilbenes, hydroxybenzaldehydes and hydroxycoumarins can contribute to BC reduction risk on all menopausal and receptor statuses.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/173027Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/nu12040994Nutrients, 2020, vol. 12, num. 4https://doi.org/10.3390/nu12040994cc by (c) Vitelli-Storelli et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1730272026-05-27T06:46:51Z
dc.title.none.fl_str_mv Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status
title Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status
spellingShingle Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status
Vitelli Storelli, Facundo
Càncer de mama
Flavonoides
Polifenols
Breast cancer
Flavonoids
Polyphenols
title_short Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status
title_full Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status
title_fullStr Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status
title_full_unstemmed Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status
title_sort Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status
dc.creator.none.fl_str_mv Vitelli Storelli, Facundo
Zamora-Ros, Raul
Molina de la Torre, Antonio José
Fernández Villa, Tania
Castelló, Adela
Barrio, Juan Pablo
Amiano, Pilar
Ardanaz, Eva
Obón Santacana, Mireia
Gómez Acebo, Inés
Fernández Tardón, Guillermo
Molina Barceló, Ana
Alguacil, Juan
Marcos Gragera, Rafael
Ruiz Moreno, Emma
Pedraza, Manuela
Gil, Leire
Guevara, Marcela
Castaño-Vinyals, Gemma
Dierssen Sotos, Trinidad
Kogevinas, Manolis
Aragonès Sanz, Núria
Martín Sánchez, Vicente
author Vitelli Storelli, Facundo
author_facet Vitelli Storelli, Facundo
Zamora-Ros, Raul
Molina de la Torre, Antonio José
Fernández Villa, Tania
Castelló, Adela
Barrio, Juan Pablo
Amiano, Pilar
Ardanaz, Eva
Obón Santacana, Mireia
Gómez Acebo, Inés
Fernández Tardón, Guillermo
Molina Barceló, Ana
Alguacil, Juan
Marcos Gragera, Rafael
Ruiz Moreno, Emma
Pedraza, Manuela
Gil, Leire
Guevara, Marcela
Castaño-Vinyals, Gemma
Dierssen Sotos, Trinidad
Kogevinas, Manolis
Aragonès Sanz, Núria
Martín Sánchez, Vicente
author_role author
author2 Zamora-Ros, Raul
Molina de la Torre, Antonio José
Fernández Villa, Tania
Castelló, Adela
Barrio, Juan Pablo
Amiano, Pilar
Ardanaz, Eva
Obón Santacana, Mireia
Gómez Acebo, Inés
Fernández Tardón, Guillermo
Molina Barceló, Ana
Alguacil, Juan
Marcos Gragera, Rafael
Ruiz Moreno, Emma
Pedraza, Manuela
Gil, Leire
Guevara, Marcela
Castaño-Vinyals, Gemma
Dierssen Sotos, Trinidad
Kogevinas, Manolis
Aragonès Sanz, Núria
Martín Sánchez, Vicente
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer de mama
Flavonoides
Polifenols
Breast cancer
Flavonoids
Polyphenols
topic Càncer de mama
Flavonoides
Polifenols
Breast cancer
Flavonoids
Polyphenols
description There is limited evidence of phenolic compounds acting as protective agents on several cancer types, including breast cancer (BC). Nevertheless, some polyphenol classes have not been investigated and there is a lack of studies assessing the effect on menopausal status and hormone receptor status as influenced by these compounds. The objective of this study is to evaluate the association between the intake of all polyphenol classes in relation to the BC risk by menopausal and hormone receptor status. We used data from a population-based multi-case-control study (MCC-Spain) including 1472 BC cases and 1577 controls from 12 different regions of Spain. The odds ratios (ORs) with 95% CI were calculated using logistic regression of mixed effects by quartiles and log2 of polyphenol intakes (adjusted for the residual method) of overall BC, menopausal and receptor status. No associations were found between total intake of polyphenols and BC risk. However, inverse associations were found between stilbenes and all BC risk (ORQ4 vs. Q1: 0.70, 95%CI: 0.56-0.89, P-trend = 0.001), the consumption of hydroxybenzaldehydes (ORQ4 vs. Q1: 0.75, 95%CI: 0.59-0.93, P-trend = 0.012) and hydroxycoumarins (ORQ4 vs. Q1: 0.73, 95%CI: 0.57-0.93; P-trend = 0.005) were also inversely associated. The intake of stilbenes, hydroxybenzaldehydes and hydroxycoumarins can contribute to BC reduction risk on all menopausal and receptor statuses.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/173027
url https://hdl.handle.net/2445/173027
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nu12040994
Nutrients, 2020, vol. 12, num. 4
https://doi.org/10.3390/nu12040994
dc.rights.none.fl_str_mv cc by (c) Vitelli-Storelli et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Vitelli-Storelli et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.298079

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