Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status

There is limited evidence of phenolic compounds acting as protective agents on several cancer types, including breast cancer (BC). Nevertheless, some polyphenol classes have not been investigated and there is a lack of studies assessing the effect on menopausal status and hormone receptor status as...

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Detalles Bibliográficos
Autores: Vitelli Storelli, Facundo, Zamora-Ros, Raul, Molina de la Torre, Antonio José, Fernández Villa, Tania, Castelló, Adela, Barrio, Juan Pablo, Amiano, Pilar, Ardanaz, Eva, Obón Santacana, Mireia, Gómez Acebo, Inés, Fernández Tardón, Guillermo, Molina Barceló, Ana, Alguacil, Juan, Marcos Gragera, Rafael, Ruiz Moreno, Emma, Pedraza, Manuela, Gil, Leire, Guevara, Marcela, Castaño-Vinyals, Gemma, Dierssen Sotos, Trinidad, Kogevinas, Manolis, Aragonès Sanz, Núria, Martín Sánchez, Vicente
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/173027
Acceso en línea:https://hdl.handle.net/2445/173027
Access Level:acceso abierto
Palabra clave:Càncer de mama
Flavonoides
Polifenols
Breast cancer
Flavonoids
Polyphenols
Descripción
Sumario:There is limited evidence of phenolic compounds acting as protective agents on several cancer types, including breast cancer (BC). Nevertheless, some polyphenol classes have not been investigated and there is a lack of studies assessing the effect on menopausal status and hormone receptor status as influenced by these compounds. The objective of this study is to evaluate the association between the intake of all polyphenol classes in relation to the BC risk by menopausal and hormone receptor status. We used data from a population-based multi-case-control study (MCC-Spain) including 1472 BC cases and 1577 controls from 12 different regions of Spain. The odds ratios (ORs) with 95% CI were calculated using logistic regression of mixed effects by quartiles and log2 of polyphenol intakes (adjusted for the residual method) of overall BC, menopausal and receptor status. No associations were found between total intake of polyphenols and BC risk. However, inverse associations were found between stilbenes and all BC risk (ORQ4 vs. Q1: 0.70, 95%CI: 0.56-0.89, P-trend = 0.001), the consumption of hydroxybenzaldehydes (ORQ4 vs. Q1: 0.75, 95%CI: 0.59-0.93, P-trend = 0.012) and hydroxycoumarins (ORQ4 vs. Q1: 0.73, 95%CI: 0.57-0.93; P-trend = 0.005) were also inversely associated. The intake of stilbenes, hydroxybenzaldehydes and hydroxycoumarins can contribute to BC reduction risk on all menopausal and receptor statuses.

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