The role of computational models in mechanobiology of growing bone

Endochondral ossification, the process by which long bones grow in length, is regulated by mechanical forces. Computational models, specifically finite element models, have been used for decades to understand the role of mechanical loading on endochondral ossification. This perspective outlines the...

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Detalles Bibliográficos
Autores: Comellas Sanfeliu, Ester|||0000-0002-3981-2634, Shefelbine, Sandra J.
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/377152
Acceso en línea:https://hdl.handle.net/2117/377152
https://dx.doi.org/10.3389/fbioe.2022.973788
Access Level:acceso abierto
Palabra clave:Bones -- Mechanical properties
Ossification
Biomechanics
Finite element method
Mechanobiology
Endochondral ossification
Finite element model (FE model)
Bone growth and development
Ossos -- Propietats mecàniques
Biomecànica
Ossificació
Elements finits, Mètode dels
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomecànica
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spelling The role of computational models in mechanobiology of growing boneComellas Sanfeliu, Ester|||0000-0002-3981-2634Shefelbine, Sandra J.Bones -- Mechanical propertiesOssificationBiomechanicsFinite element methodMechanobiologyEndochondral ossificationFinite element model (FE model)BiomechanicsBone growth and developmentOssos -- Propietats mecàniquesBiomecànicaOssificacióElements finits, Mètode delsÀrees temàtiques de la UPC::Enginyeria biomèdica::BiomecànicaEndochondral ossification, the process by which long bones grow in length, is regulated by mechanical forces. Computational models, specifically finite element models, have been used for decades to understand the role of mechanical loading on endochondral ossification. This perspective outlines the stages of model development in which models are used to: 1) explore phenomena, 2) explain pathologies, 3) predict clinical outcomes, and 4) design therapies. As the models progress through the stages, they increase in specificity and biofidelity. We give specific examples of models of endochondral ossification and expect models of other mechanobiological systems to follow similar development stages.Peer ReviewedFrontiers Media SA20222022-11-1820222022-11-25journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/377152https://dx.doi.org/10.3389/fbioe.2022.973788reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3771522026-05-27T15:37:01Z
dc.title.none.fl_str_mv The role of computational models in mechanobiology of growing bone
title The role of computational models in mechanobiology of growing bone
spellingShingle The role of computational models in mechanobiology of growing bone
Comellas Sanfeliu, Ester|||0000-0002-3981-2634
Bones -- Mechanical properties
Ossification
Biomechanics
Finite element method
Mechanobiology
Endochondral ossification
Finite element model (FE model)
Biomechanics
Bone growth and development
Ossos -- Propietats mecàniques
Biomecànica
Ossificació
Elements finits, Mètode dels
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomecànica
title_short The role of computational models in mechanobiology of growing bone
title_full The role of computational models in mechanobiology of growing bone
title_fullStr The role of computational models in mechanobiology of growing bone
title_full_unstemmed The role of computational models in mechanobiology of growing bone
title_sort The role of computational models in mechanobiology of growing bone
dc.creator.none.fl_str_mv Comellas Sanfeliu, Ester|||0000-0002-3981-2634
Shefelbine, Sandra J.
author Comellas Sanfeliu, Ester|||0000-0002-3981-2634
author_facet Comellas Sanfeliu, Ester|||0000-0002-3981-2634
Shefelbine, Sandra J.
author_role author
author2 Shefelbine, Sandra J.
author2_role author
dc.subject.none.fl_str_mv Bones -- Mechanical properties
Ossification
Biomechanics
Finite element method
Mechanobiology
Endochondral ossification
Finite element model (FE model)
Biomechanics
Bone growth and development
Ossos -- Propietats mecàniques
Biomecànica
Ossificació
Elements finits, Mètode dels
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomecànica
topic Bones -- Mechanical properties
Ossification
Biomechanics
Finite element method
Mechanobiology
Endochondral ossification
Finite element model (FE model)
Biomechanics
Bone growth and development
Ossos -- Propietats mecàniques
Biomecànica
Ossificació
Elements finits, Mètode dels
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomecànica
description Endochondral ossification, the process by which long bones grow in length, is regulated by mechanical forces. Computational models, specifically finite element models, have been used for decades to understand the role of mechanical loading on endochondral ossification. This perspective outlines the stages of model development in which models are used to: 1) explore phenomena, 2) explain pathologies, 3) predict clinical outcomes, and 4) design therapies. As the models progress through the stages, they increase in specificity and biofidelity. We give specific examples of models of endochondral ossification and expect models of other mechanobiological systems to follow similar development stages.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-11-18
2022
2022-11-25
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/377152
https://dx.doi.org/10.3389/fbioe.2022.973788
url https://hdl.handle.net/2117/377152
https://dx.doi.org/10.3389/fbioe.2022.973788
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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