The role of computational models in mechanobiology of growing bone
Endochondral ossification, the process by which long bones grow in length, is regulated by mechanical forces. Computational models, specifically finite element models, have been used for decades to understand the role of mechanical loading on endochondral ossification. This perspective outlines the...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/377152 |
| Acceso en línea: | https://hdl.handle.net/2117/377152 https://dx.doi.org/10.3389/fbioe.2022.973788 |
| Access Level: | acceso abierto |
| Palabra clave: | Bones -- Mechanical properties Ossification Biomechanics Finite element method Mechanobiology Endochondral ossification Finite element model (FE model) Bone growth and development Ossos -- Propietats mecàniques Biomecànica Ossificació Elements finits, Mètode dels Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomecànica |
| Sumario: | Endochondral ossification, the process by which long bones grow in length, is regulated by mechanical forces. Computational models, specifically finite element models, have been used for decades to understand the role of mechanical loading on endochondral ossification. This perspective outlines the stages of model development in which models are used to: 1) explore phenomena, 2) explain pathologies, 3) predict clinical outcomes, and 4) design therapies. As the models progress through the stages, they increase in specificity and biofidelity. We give specific examples of models of endochondral ossification and expect models of other mechanobiological systems to follow similar development stages. |
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