Applicability and validation of different prognostic scores in allogeneic hematopoietic cell transplant (HCT) in the post-transplant cyclophosphamide era

We investigated the predictive capacity of six prognostic indices [Karnofsky Performance Status (KPS), Hematopoietic Cell Transplant-Specific Comorbidity Index (HCT-CI), Disease Risk Index (DRI), European Bone Marrow Transplantation (EBMT) and Revised Pre-Transplantation Assessment of Mortality (rPA...

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Detalhes bibliográficos
Autores: Salas, María Queralt|||0000-0003-4567-3682, Rodríguez Lobato, Luis Gerardo|||0000-0001-5694-0921, Charry, Paola|||0000-0002-4777-9643, Suárez-Lledó, Maria, Pedraza, Alexandra|||0000-0002-6039-8140, Solano, María Teresa, Arcarons, Jordi|||0000-0002-1356-6260, Cid, Joan|||0000-0001-5445-4508, Lozano, Miquel|||0000-0003-2593-833X, Rosiñol, Laura|||0000-0002-2534-9239, Esteve Reyner, Jordi|||0000-0002-8056-648X, Carreras, Enric|||0000-0002-3134-9964, Fernandez Aviles, Francesc|||0000-0003-3051-3926, Martínez, Carmen|||0000-0002-8401-7306, Rovira Tarrats, Montserrat|||0000-0002-6403-3317
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:289763
Acesso em linha:https://ddd.uab.cat/record/289763
https://dx.doi.org/urn:doi:10.1016/j.htct.2023.07.008
Access Level:acceso abierto
Palavra-chave:Post-transplant cyclophosphamide
Allogeneic hematopoietic cell
Transplantation
Indices
Validation
Descrição
Resumo:We investigated the predictive capacity of six prognostic indices [Karnofsky Performance Status (KPS), Hematopoietic Cell Transplant-Specific Comorbidity Index (HCT-CI), Disease Risk Index (DRI), European Bone Marrow Transplantation (EBMT) and Revised Pre-Transplantation Assessment of Mortality (rPAM) Scores and Endothelial Activation and Stress Index (EASIX)] in 205 adults undergoing post-transplant cyclophosphamide (PTCy)-based allo-HCT. KPS, HCT-CI, DRI and EASIX grouped patients into higher and lower risk strata. KPS and EASIX maintained appropriate discrimination for OS prediction across the first 2 years after allo-HCT [receiver operating characteristic curve (area under the curve (AUC) > 55 %)]. The discriminative capacity of DRI and HCT-CI increased during the post-transplant period, with a peak of prediction at 2 years (AUC of 61.1 % and 61.8 %). The maximum rPAM discriminative capacity was at 1 year (1-year AUC of 58.2 %). The predictive capacity of the EBMT score was not demonstrated. This study validates the discrimination capacity for OS prediction of KPS, HCT-CI, DRI and EASIX in PTCy-based allo-HCT.

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