The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium

Purpose: It is suggested that polyphenols back the cardiovascular protection offered by the Mediterranean diet. This study evaluates the association of specific types of dietary polyphenols with prevalent subclinical atherosclerosis in middle-aged subjects. Methods: Ultrasonography and TC were perfo...

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Autores: Montero Salazar, Henry, de Deus Mendonça, Raquel, Laclaustra, Martín, Moreno Franco, Belén, Åkesson, Agneta, Guallar Castillón, María Pilar, Donat Vargas, Carolina
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/703019
Acesso em linha:http://hdl.handle.net/10486/703019
https://dx.doi.org/10.1007/s00394-022-02823-0
Access Level:acceso abierto
Palavra-chave:Coronary calcium
Cross-sectional cohort study
Flavonoids
Red wine
Stilbenes
Subclinical coronary atherosclerosis
Medicina
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spelling The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calciumMontero Salazar, Henryde Deus Mendonça, RaquelLaclaustra, MartínMoreno Franco, BelénÅkesson, AgnetaGuallar Castillón, María PilarDonat Vargas, CarolinaCoronary calciumCross-sectional cohort studyFlavonoidsRed wineStilbenesSubclinical coronary atherosclerosisMedicinaPurpose: It is suggested that polyphenols back the cardiovascular protection offered by the Mediterranean diet. This study evaluates the association of specific types of dietary polyphenols with prevalent subclinical atherosclerosis in middle-aged subjects. Methods: Ultrasonography and TC were performed on 2318 men from the Aragon Workers Health Study, recruited between 2011 and 2014, to assess the presence of plaques in carotid and femoral arteries and coronary calcium. Polyphenol intake was assessed using a validated semi-quantitative 136-item food frequency questionnaire. The Phenol Explorer database was used to derive polyphenol class intake. Logistic and linear regressions were used to estimate the cross-sectional association of polyphenols intake with femoral and carotid subclinical atherosclerosis and coronary calcium. Results: A higher intake of flavonoids (third vs. first tertile) was associated with a lower risk of both carotid (OR 0.80: CI 95% 0.62–1.02; P trend 0.094) and femoral (0.62: 0.48–0.80, P trend < 0.001) subclinical atherosclerosis. A higher intake of stilbenes was associated with a lower risk of femoral subclinical atherosclerosis (0.62: 0.46–0.83; P trend 0.009) and positive coronary calcium (0.75: 0.55–1.03; P trend 0.131). A higher intake of tyrosols was also associated with a lower risk of positive coronary calcium (0.80: 0.62–1.03; P trend 0.111). The associations remained similar when adjusted for blood lipids and blood pressure. Conclusion: Dietary flavonoids, stilbenes, and tyrosols, whose main sources are red wine and virgin olive oil, are associated with lower prevalence of subclinical atherosclerosis in middle-aged subjects.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study was also supported in part by CIBERCV, CIBERESP and Grants: PIE16 / 00022, PI17/1709, PI19/00948, PI20/144 from the Instituto de Salud Carlos III (co-supported by the European Regional Development Fund ‘Investing in your future’). CD-V has a Talent Attraction Contract (“Contrato Atracción de Talento”) from the Regional Government of the Madrid Community/IMDEA FoodSpringerDepartamento de Medicina Preventiva y Salud Pública y MicrobiologíaFacultad de Medicina20222022-03-07research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/703019https://dx.doi.org/10.1007/s00394-022-02823-0reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7030192026-06-23T12:46:27Z
dc.title.none.fl_str_mv The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium
title The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium
spellingShingle The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium
Montero Salazar, Henry
Coronary calcium
Cross-sectional cohort study
Flavonoids
Red wine
Stilbenes
Subclinical coronary atherosclerosis
Medicina
title_short The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium
title_full The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium
title_fullStr The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium
title_full_unstemmed The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium
title_sort The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium
dc.creator.none.fl_str_mv Montero Salazar, Henry
de Deus Mendonça, Raquel
Laclaustra, Martín
Moreno Franco, Belén
Åkesson, Agneta
Guallar Castillón, María Pilar
Donat Vargas, Carolina
author Montero Salazar, Henry
author_facet Montero Salazar, Henry
de Deus Mendonça, Raquel
Laclaustra, Martín
Moreno Franco, Belén
Åkesson, Agneta
Guallar Castillón, María Pilar
Donat Vargas, Carolina
author_role author
author2 de Deus Mendonça, Raquel
Laclaustra, Martín
Moreno Franco, Belén
Åkesson, Agneta
Guallar Castillón, María Pilar
Donat Vargas, Carolina
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina Preventiva y Salud Pública y Microbiología
Facultad de Medicina
dc.subject.none.fl_str_mv Coronary calcium
Cross-sectional cohort study
Flavonoids
Red wine
Stilbenes
Subclinical coronary atherosclerosis
Medicina
topic Coronary calcium
Cross-sectional cohort study
Flavonoids
Red wine
Stilbenes
Subclinical coronary atherosclerosis
Medicina
description Purpose: It is suggested that polyphenols back the cardiovascular protection offered by the Mediterranean diet. This study evaluates the association of specific types of dietary polyphenols with prevalent subclinical atherosclerosis in middle-aged subjects. Methods: Ultrasonography and TC were performed on 2318 men from the Aragon Workers Health Study, recruited between 2011 and 2014, to assess the presence of plaques in carotid and femoral arteries and coronary calcium. Polyphenol intake was assessed using a validated semi-quantitative 136-item food frequency questionnaire. The Phenol Explorer database was used to derive polyphenol class intake. Logistic and linear regressions were used to estimate the cross-sectional association of polyphenols intake with femoral and carotid subclinical atherosclerosis and coronary calcium. Results: A higher intake of flavonoids (third vs. first tertile) was associated with a lower risk of both carotid (OR 0.80: CI 95% 0.62–1.02; P trend 0.094) and femoral (0.62: 0.48–0.80, P trend < 0.001) subclinical atherosclerosis. A higher intake of stilbenes was associated with a lower risk of femoral subclinical atherosclerosis (0.62: 0.46–0.83; P trend 0.009) and positive coronary calcium (0.75: 0.55–1.03; P trend 0.131). A higher intake of tyrosols was also associated with a lower risk of positive coronary calcium (0.80: 0.62–1.03; P trend 0.111). The associations remained similar when adjusted for blood lipids and blood pressure. Conclusion: Dietary flavonoids, stilbenes, and tyrosols, whose main sources are red wine and virgin olive oil, are associated with lower prevalence of subclinical atherosclerosis in middle-aged subjects.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-03-07
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/703019
https://dx.doi.org/10.1007/s00394-022-02823-0
url http://hdl.handle.net/10486/703019
https://dx.doi.org/10.1007/s00394-022-02823-0
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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