Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantation

Gagelmann, N.|||0000-0002-0891-1744; Eikema, D. J.; Stelljes, M.; Beelen, Dietrich; de Wreede, Liesbeth C.|||0000-0002-7667-9369; Mufti, G.; Knelange, N. S.; Niederwieser, Dietger|||0000-0002-4737-1103; Friis, L. S.; Ehninger, Gerhard; Nagler, Arnon; Yakoub-Agha, Ibrahim|||0000-0003-4524-8782; Meijer, Ellen; Ljungman, Per|||0000-0002-8281-3245; Maertens, Johan|||0000-0003-4257-5980; Kanz, L.; Lopez-Corral, L.; Brecht, A.; Craddock, Charles|||0000-0001-5041-6678; Finke, Juergen|||0000-0002-1799-5927; Cornelissen, J. J.; Bernasconi, P.; Chevallier, Patrice|||0000-0003-3142-5581; Sierra, Jorge|||0000-0002-7966-0356; Robin, M.; Kroeger, Nicolaus|||0000-0001-5103-9966

Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantation

The aim of this study was to develop and validate a clinical and transplant-specific prognostic score using data from a large cohort of patients with myelodysplastic syndromes reported to the European Society for Blood and Marrow Transplantation registry. A Cox model was fitted to detect clinical an...

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Autores:	Gagelmann, N.\|\|\|0000-0002-0891-1744, Eikema, D. J., Stelljes, M., Beelen, Dietrich, de Wreede, Liesbeth C.\|\|\|0000-0002-7667-9369, Mufti, G., Knelange, N. S., Niederwieser, Dietger\|\|\|0000-0002-4737-1103, Friis, L. S., Ehninger, Gerhard, Nagler, Arnon, Yakoub-Agha, Ibrahim\|\|\|0000-0003-4524-8782, Meijer, Ellen, Ljungman, Per\|\|\|0000-0002-8281-3245, Maertens, Johan\|\|\|0000-0003-4257-5980, Kanz, L., Lopez-Corral, L., Brecht, A., Craddock, Charles\|\|\|0000-0001-5041-6678, Finke, Juergen\|\|\|0000-0002-1799-5927, Cornelissen, J. J., Bernasconi, P., Chevallier, Patrice\|\|\|0000-0003-3142-5581, Sierra, Jorge\|\|\|0000-0002-7966-0356, Robin, M., Kroeger, Nicolaus\|\|\|0000-0001-5103-9966
Tipo de recurso:	artículo
Fecha de publicación:	2019
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:237180
Acceso en línea:	https://ddd.uab.cat/record/237180 https://dx.doi.org/urn:doi:10.3324/haematol.2018.200808
Access Level:	acceso abierto
Palabra clave:	Adolescent Adult Aged Cohort Studies Female Follow-Up Studies Hematopoietic Stem Cell Transplantation Humans Male Middle Aged Models, Statistical Myelodysplastic Syndromes Nomograms Prognosis Risk Assessment Risk Factors Survival Rate Transplantation, Homologous Young Adult

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spelling	Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantationGagelmann, N.\|\|\|0000-0002-0891-1744Eikema, D. J.Stelljes, M.Beelen, Dietrichde Wreede, Liesbeth C.\|\|\|0000-0002-7667-9369Mufti, G.Knelange, N. S.Niederwieser, Dietger\|\|\|0000-0002-4737-1103Friis, L. S.Ehninger, GerhardNagler, ArnonYakoub-Agha, Ibrahim\|\|\|0000-0003-4524-8782Meijer, EllenLjungman, Per\|\|\|0000-0002-8281-3245Maertens, Johan\|\|\|0000-0003-4257-5980Kanz, L.Lopez-Corral, L.Brecht, A.Craddock, Charles\|\|\|0000-0001-5041-6678Finke, Juergen\|\|\|0000-0002-1799-5927Cornelissen, J. J.Bernasconi, P.Chevallier, Patrice\|\|\|0000-0003-3142-5581Sierra, Jorge\|\|\|0000-0002-7966-0356Robin, M.Kroeger, Nicolaus\|\|\|0000-0001-5103-9966AdolescentAdultAgedCohort StudiesFemaleFollow-Up StudiesHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedModels, StatisticalMyelodysplastic SyndromesNomogramsPrognosisRisk AssessmentRisk FactorsSurvival RateTransplantation, HomologousYoung AdultThe aim of this study was to develop and validate a clinical and transplant-specific prognostic score using data from a large cohort of patients with myelodysplastic syndromes reported to the European Society for Blood and Marrow Transplantation registry. A Cox model was fitted to detect clinical and transplant-related variables prognostic of outcome. Then, cross-validation was performed to evaluate the validity and consistency of the model. Seven independent risk factors for survival were identified: age ≥50 years, matched unrelated donor, Karnofsky Performance Status <90%, very poor cytogenetics or monosomal karyotype, positive cytomegalovirus status of the recipient, blood blasts.Universitat Autònoma de Barcelona 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/237180https://dx.doi.org/urn:doi:10.3324/haematol.2018.200808reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2371802026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantation
title	Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantation
spellingShingle	Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantation Gagelmann, N.\|\|\|0000-0002-0891-1744 Adolescent Adult Aged Cohort Studies Female Follow-Up Studies Hematopoietic Stem Cell Transplantation Humans Male Middle Aged Models, Statistical Myelodysplastic Syndromes Nomograms Prognosis Risk Assessment Risk Factors Survival Rate Transplantation, Homologous Young Adult
title_short	Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantation
title_full	Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantation
title_fullStr	Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantation
title_full_unstemmed	Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantation
title_sort	Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantation
dc.creator.none.fl_str_mv	Gagelmann, N.\|\|\|0000-0002-0891-1744 Eikema, D. J. Stelljes, M. Beelen, Dietrich de Wreede, Liesbeth C.\|\|\|0000-0002-7667-9369 Mufti, G. Knelange, N. S. Niederwieser, Dietger\|\|\|0000-0002-4737-1103 Friis, L. S. Ehninger, Gerhard Nagler, Arnon Yakoub-Agha, Ibrahim\|\|\|0000-0003-4524-8782 Meijer, Ellen Ljungman, Per\|\|\|0000-0002-8281-3245 Maertens, Johan\|\|\|0000-0003-4257-5980 Kanz, L. Lopez-Corral, L. Brecht, A. Craddock, Charles\|\|\|0000-0001-5041-6678 Finke, Juergen\|\|\|0000-0002-1799-5927 Cornelissen, J. J. Bernasconi, P. Chevallier, Patrice\|\|\|0000-0003-3142-5581 Sierra, Jorge\|\|\|0000-0002-7966-0356 Robin, M. Kroeger, Nicolaus\|\|\|0000-0001-5103-9966
author	Gagelmann, N.\|\|\|0000-0002-0891-1744
author_facet	Gagelmann, N.\|\|\|0000-0002-0891-1744 Eikema, D. J. Stelljes, M. Beelen, Dietrich de Wreede, Liesbeth C.\|\|\|0000-0002-7667-9369 Mufti, G. Knelange, N. S. Niederwieser, Dietger\|\|\|0000-0002-4737-1103 Friis, L. S. Ehninger, Gerhard Nagler, Arnon Yakoub-Agha, Ibrahim\|\|\|0000-0003-4524-8782 Meijer, Ellen Ljungman, Per\|\|\|0000-0002-8281-3245 Maertens, Johan\|\|\|0000-0003-4257-5980 Kanz, L. Lopez-Corral, L. Brecht, A. Craddock, Charles\|\|\|0000-0001-5041-6678 Finke, Juergen\|\|\|0000-0002-1799-5927 Cornelissen, J. J. Bernasconi, P. Chevallier, Patrice\|\|\|0000-0003-3142-5581 Sierra, Jorge\|\|\|0000-0002-7966-0356 Robin, M. Kroeger, Nicolaus\|\|\|0000-0001-5103-9966
author_role	author
author2	Eikema, D. J. Stelljes, M. Beelen, Dietrich de Wreede, Liesbeth C.\|\|\|0000-0002-7667-9369 Mufti, G. Knelange, N. S. Niederwieser, Dietger\|\|\|0000-0002-4737-1103 Friis, L. S. Ehninger, Gerhard Nagler, Arnon Yakoub-Agha, Ibrahim\|\|\|0000-0003-4524-8782 Meijer, Ellen Ljungman, Per\|\|\|0000-0002-8281-3245 Maertens, Johan\|\|\|0000-0003-4257-5980 Kanz, L. Lopez-Corral, L. Brecht, A. Craddock, Charles\|\|\|0000-0001-5041-6678 Finke, Juergen\|\|\|0000-0002-1799-5927 Cornelissen, J. J. Bernasconi, P. Chevallier, Patrice\|\|\|0000-0003-3142-5581 Sierra, Jorge\|\|\|0000-0002-7966-0356 Robin, M. Kroeger, Nicolaus\|\|\|0000-0001-5103-9966
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv	Adolescent Adult Aged Cohort Studies Female Follow-Up Studies Hematopoietic Stem Cell Transplantation Humans Male Middle Aged Models, Statistical Myelodysplastic Syndromes Nomograms Prognosis Risk Assessment Risk Factors Survival Rate Transplantation, Homologous Young Adult
topic	Adolescent Adult Aged Cohort Studies Female Follow-Up Studies Hematopoietic Stem Cell Transplantation Humans Male Middle Aged Models, Statistical Myelodysplastic Syndromes Nomograms Prognosis Risk Assessment Risk Factors Survival Rate Transplantation, Homologous Young Adult
description	The aim of this study was to develop and validate a clinical and transplant-specific prognostic score using data from a large cohort of patients with myelodysplastic syndromes reported to the European Society for Blood and Marrow Transplantation registry. A Cox model was fitted to detect clinical and transplant-related variables prognostic of outcome. Then, cross-validation was performed to evaluate the validity and consistency of the model. Seven independent risk factors for survival were identified: age ≥50 years, matched unrelated donor, Karnofsky Performance Status <90%, very poor cytogenetics or monosomal karyotype, positive cytomegalovirus status of the recipient, blood blasts.
publishDate	2019
dc.date.none.fl_str_mv	2 2019-01-01 2019 2019-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/237180 https://dx.doi.org/urn:doi:10.3324/haematol.2018.200808
url	https://ddd.uab.cat/record/237180 https://dx.doi.org/urn:doi:10.3324/haematol.2018.200808
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
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Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantation

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