Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantation

The aim of this study was to develop and validate a clinical and transplant-specific prognostic score using data from a large cohort of patients with myelodysplastic syndromes reported to the European Society for Blood and Marrow Transplantation registry. A Cox model was fitted to detect clinical an...

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Detalles Bibliográficos
Autores: Gagelmann, N.|||0000-0002-0891-1744, Eikema, D. J., Stelljes, M., Beelen, Dietrich, de Wreede, Liesbeth C.|||0000-0002-7667-9369, Mufti, G., Knelange, N. S., Niederwieser, Dietger|||0000-0002-4737-1103, Friis, L. S., Ehninger, Gerhard, Nagler, Arnon, Yakoub-Agha, Ibrahim|||0000-0003-4524-8782, Meijer, Ellen, Ljungman, Per|||0000-0002-8281-3245, Maertens, Johan|||0000-0003-4257-5980, Kanz, L., Lopez-Corral, L., Brecht, A., Craddock, Charles|||0000-0001-5041-6678, Finke, Juergen|||0000-0002-1799-5927, Cornelissen, J. J., Bernasconi, P., Chevallier, Patrice|||0000-0003-3142-5581, Sierra, Jorge|||0000-0002-7966-0356, Robin, M., Kroeger, Nicolaus|||0000-0001-5103-9966
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:237180
Acceso en línea:https://ddd.uab.cat/record/237180
https://dx.doi.org/urn:doi:10.3324/haematol.2018.200808
Access Level:acceso abierto
Palabra clave:Adolescent
Adult
Aged
Cohort Studies
Female
Follow-Up Studies
Hematopoietic Stem Cell Transplantation
Humans
Male
Middle Aged
Models, Statistical
Myelodysplastic Syndromes
Nomograms
Prognosis
Risk Assessment
Risk Factors
Survival Rate
Transplantation, Homologous
Young Adult
Descripción
Sumario:The aim of this study was to develop and validate a clinical and transplant-specific prognostic score using data from a large cohort of patients with myelodysplastic syndromes reported to the European Society for Blood and Marrow Transplantation registry. A Cox model was fitted to detect clinical and transplant-related variables prognostic of outcome. Then, cross-validation was performed to evaluate the validity and consistency of the model. Seven independent risk factors for survival were identified: age ≥50 years, matched unrelated donor, Karnofsky Performance Status <90%, very poor cytogenetics or monosomal karyotype, positive cytomegalovirus status of the recipient, blood blasts.

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