Oxidative damage in reperfusion after stroke: ferroptosis and the role of the mitochondrial sodium/calcium exchanger NCLX
Stroke is a highly prevalent neurological disease with significant social and healthcare impact, being one of the leading causes of permanent disability and death in the adult population. Ischemic stroke, the most common subtype, is characterized by the interruption of cerebral blood flow, leading t...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/133930 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/133930 |
| Access Level: | acceso abierto |
| Palabra clave: | 616.831-005.1(043.2) Reperfusion Stroke Oxidative damage Ferroptosis Reperfusión Ictus Daño oxidativo Neurociencias (Farmacia) Neurociencias (Medicina) 3207.11 Neuropatología 6106.01 Actividad Cerebral |
| Sumario: | Stroke is a highly prevalent neurological disease with significant social and healthcare impact, being one of the leading causes of permanent disability and death in the adult population. Ischemic stroke, the most common subtype, is characterized by the interruption of cerebral blood flow, leading to a severe reduction in the supply of oxygen and nutrients essential for neuronal viability. This condition causes initial ischemic injury, followed by a reperfusion phase intended to restore blood flow. Paradoxically, reperfusion can aggravate tissue damage. This phenomenon, known as ischemia-reperfusion injury, is mediated by increased oxidative stress, mitochondrial dysfunction, and an exacerbated inflammatory response.In this context, various types of cell death have been identified as contributors to brain injury, including apoptosis, necrosis, autophagy, and more recently, ferroptosis, an iron-dependent form of cell death characterized by the accumulation of lipid peroxides. This process has been associated with altered iron metabolism and excessive reactive oxygen species (ROS), which trigger peroxidation of membrane lipids and compromise cell integrity... |
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