Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions

The Minibrain (Mnb) gene encodes a new family of protein kinases that is evolutionarily conserved from insects to humans. In Drosophila, Mnb is involved in postembryonic neurogenesis. In humans, MNB has been mapped within the Down's Syndrome (DS) critical region of chromosome 21 and is overexpr...

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Detalles Bibliográficos
Autores: Hämmerle, Barbara, Vera-Samper, Eva, Speicher, Stephan, Arencibia, R., Martínez, Salvador, Tejedor, Francisco J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2002
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/309163
Acceso en línea:http://hdl.handle.net/10261/309163
Access Level:acceso abierto
Palabra clave:Minibrain
Mnb
Dyrk1A
Brain development
Neurogenesis
Progenitor cells
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spelling Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisionsHämmerle, BarbaraVera-Samper, EvaSpeicher, StephanArencibia, R.Martínez, SalvadorTejedor, Francisco J.MinibrainMnbDyrk1ABrain developmentNeurogenesisProgenitor cellsThe Minibrain (Mnb) gene encodes a new family of protein kinases that is evolutionarily conserved from insects to humans. In Drosophila, Mnb is involved in postembryonic neurogenesis. In humans, MNB has been mapped within the Down's Syndrome (DS) critical region of chromosome 21 and is overexpressed in DS embryonic brain. In order to study a possible role of Mnb on the neurogenesis of vertebrate brain, we have cloned the chick Mnb orthologue and studied the spatiotemporal expression of Mnb in proliferative regions of the nervous system. In early embryos, Mnb is expressed before the onset of neurogenesis in the three general locations where neuronal precursors are originated: neuroepithelia of the neural tube, neural crest, and cranial placodes. Mnb is transiently expressed during a single cell cycle of neuroepithelial progenitor (NEP) cells. Mnb expression precedes and widely overlaps with the expression of Tis21, an antiproliferative gene that has been reported to be expressed in the onset of neurogenic divisions of NEP cells. Mnb transcription begins in mitosis, continues during G1, and stops before S-phase. Very interestingly, we have found that Mnb mRNA is asymmetrically localized during the mitosis of these cells and inherited by one of the sibling cells after division. We propose that Mnb defines a transition step between proliferating and neurogenic divisions of NEP cells.This work was supported by grants of the DGESIC, Fundacion La Caixa, and Fundacion Mapfre-Medicina (to F.J.T.), Fundacion Seneca, DIGESIC-MEC PM98-56, and EU Contracts QLRT-1999-31625 and QLRT-2000-02310 (to S.M.)Peer reviewedElsevierEuropean CommissionFundación la CaixaFundación SénecaFundación MapfreConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232002info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/309163reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésDevelopmental Biologyhttps://doi.org/10.1006/dbio.2002.0675Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3091632026-05-22T06:33:51Z
dc.title.none.fl_str_mv Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions
title Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions
spellingShingle Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions
Hämmerle, Barbara
Minibrain
Mnb
Dyrk1A
Brain development
Neurogenesis
Progenitor cells
title_short Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions
title_full Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions
title_fullStr Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions
title_full_unstemmed Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions
title_sort Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions
dc.creator.none.fl_str_mv Hämmerle, Barbara
Vera-Samper, Eva
Speicher, Stephan
Arencibia, R.
Martínez, Salvador
Tejedor, Francisco J.
author Hämmerle, Barbara
author_facet Hämmerle, Barbara
Vera-Samper, Eva
Speicher, Stephan
Arencibia, R.
Martínez, Salvador
Tejedor, Francisco J.
author_role author
author2 Vera-Samper, Eva
Speicher, Stephan
Arencibia, R.
Martínez, Salvador
Tejedor, Francisco J.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Fundación la Caixa
Fundación Séneca
Fundación Mapfre
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Minibrain
Mnb
Dyrk1A
Brain development
Neurogenesis
Progenitor cells
topic Minibrain
Mnb
Dyrk1A
Brain development
Neurogenesis
Progenitor cells
description The Minibrain (Mnb) gene encodes a new family of protein kinases that is evolutionarily conserved from insects to humans. In Drosophila, Mnb is involved in postembryonic neurogenesis. In humans, MNB has been mapped within the Down's Syndrome (DS) critical region of chromosome 21 and is overexpressed in DS embryonic brain. In order to study a possible role of Mnb on the neurogenesis of vertebrate brain, we have cloned the chick Mnb orthologue and studied the spatiotemporal expression of Mnb in proliferative regions of the nervous system. In early embryos, Mnb is expressed before the onset of neurogenesis in the three general locations where neuronal precursors are originated: neuroepithelia of the neural tube, neural crest, and cranial placodes. Mnb is transiently expressed during a single cell cycle of neuroepithelial progenitor (NEP) cells. Mnb expression precedes and widely overlaps with the expression of Tis21, an antiproliferative gene that has been reported to be expressed in the onset of neurogenic divisions of NEP cells. Mnb transcription begins in mitosis, continues during G1, and stops before S-phase. Very interestingly, we have found that Mnb mRNA is asymmetrically localized during the mitosis of these cells and inherited by one of the sibling cells after division. We propose that Mnb defines a transition step between proliferating and neurogenic divisions of NEP cells.
publishDate 2002
dc.date.none.fl_str_mv 2002
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/309163
url http://hdl.handle.net/10261/309163
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Developmental Biology
https://doi.org/10.1006/dbio.2002.0675
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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