IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper
Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, c...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:227656 |
| Acceso en línea: | https://ddd.uab.cat/record/227656 https://dx.doi.org/urn:doi:10.1016/j.waojou.2019.100080 |
| Access Level: | acceso abierto |
| Palabra clave: | IgE Allergy In vitro tests Skin tests Diagnostic strategies AAAAI, American Academy of Allergy Asthma and Immunology ABA, Allergen Bead Array ACAAI, American College of Allergy Asthma and Immunology AIT, allergen immunotherapy AEC, Allergen Exposure Chambers Anti-IgE, Antibody against IgE AP, Alkaline Phosphatase AU/mL, Allergenic Units milliLiter BAT, Basophil Activation Test BAU/mL, Biologic Allergenic Units milliLiter CaFE, Calibrated Fluorescence Enhancement CBA, Cytometric Bead Array CCD, Cross-reactive Carbohydrate Determinants CDER, Center for Drug Evaluation and Research (USA) CL, Chemiluminescence DBPCFC, Double-Blind Placebo-Controlled Food Challenge EAACI, European Academy of Allergy and Immunology EIA, Enzyme Immune Assay ELISA, Enzyme Linked Immuno Sorbent Analysis EMEA, European MEdicine Agencies ENPP-3, EctoNucleotide Pyrophosphatase/Phosphodiesterase 3 FACS, Fluorescence-Activated Cell Sorting FDA, Food and Drug Administration (U.S. Department of Health and Human Services) FEIA, Fluorescent Enzyme Immunoassays FcεRI, High affinity IgE receptor H1, Histamine 1 receptor H2, Histamine 2 receptor HPO, Horseradish Peroxidase IDT, Intradermal Test IgE, immunoglobulin E ISAC, Immuno-Solid phase Allergen Chip IUIS, International Union of Immunological Societies IVD, in vitro diagnostic tool Ku/l, kilo Units of Allergen/Liter for allergen-specific IgE antibody assays LAMP-3, Lysosomal-Associated Membrane Protein Mab, Monoclonal Antibody MRGPRX2, Mas-related G protein receptor 2 MBAD, Molecule Based Allergy Diagnostics NIH, National Institutes of Health (USA) NMBAs, NeuroMuscular Blocking Agents NPA, Negative Percent Agreement NSAIDs, Non-Steroidal Anti-Inflammatory Drugs Pnpp, p -Nitrophenylphosphate PPA, Positive Percent Agreement PPT, Prick-Prick Test Sige, specific IgE RAST, Radio Allergo Sorbent Test SCAR, severe cutaneous adverse drug reactions SPT, Skin prick test W/v, weight /volume |
| Sumario: | Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen. |
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