Ankyrin Repeat and Kinase Domain Containing 1 Gene, and Addiction Vulnerability

The TaqIA single nucleotide variant (SNV) has been tested for association with addictions in a huge number of studies. TaqIA is located in the ankyrin repeat and kinase domain containing 1 gene (ANKK1) that codes for a receptor interacting protein kinase. ANKK1 maps on the NTAD cluster along with th...

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Detalles Bibliográficos
Autores: Koeneke, Alejandra, Ponce Alfaro, Guillermo, Troya-Balseca, Johanna, Palomo Álvarez, Tomás, Hoenicka, Janet
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/8196
Acceso en línea:https://hdl.handle.net/20.500.14352/8196
Access Level:acceso abierto
Palabra clave:ANKK1
TaqIA
DRD2
addictions
dopamine
neurodevelopment
Neurociencias (Medicina)
Psiquiatría
2490 Neurociencias
3211 Psiquiatría
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repository_id_str
spelling Ankyrin Repeat and Kinase Domain Containing 1 Gene, and Addiction VulnerabilityKoeneke, AlejandraPonce Alfaro, GuillermoTroya-Balseca, JohannaPalomo Álvarez, TomásHoenicka, JanetANKK1TaqIADRD2addictionsdopamineneurodevelopmentNeurociencias (Medicina)Psiquiatría2490 Neurociencias3211 PsiquiatríaThe TaqIA single nucleotide variant (SNV) has been tested for association with addictions in a huge number of studies. TaqIA is located in the ankyrin repeat and kinase domain containing 1 gene (ANKK1) that codes for a receptor interacting protein kinase. ANKK1 maps on the NTAD cluster along with the dopamine receptor D2 (DRD2), the tetratricopeptide repeat domain 12 (TTC12) and the neural cell adhesion molecule 1 (NCAM1) genes. The four genes have been associated with addictions, although TTC12 and ANKK1 showed the strongest associations. In silico and in vitro studies revealed that ANKK1 is functionally related to the dopaminergic system, in particular with DRD2. In antisocial alcoholism, epistasis between ANKK1 TaqIA and DRD2 C957T SNVs has been described. This clinical finding has been supported by the study of ANKK1 expression in peripheral blood mononuclear cells of alcoholic patients and controls. Regarding the ANKK1 protein, there is direct evidence of its location in adult and developing central nervous system. Together, these findings of the ANKK1 gene and its protein suggest that the TaqIA SNV is a marker of brain differences, both in structure and in dopaminergic function, that increase individual risk to addiction development.MDPIUniversidad Complutense de Madrid20202020-04-0420202020-04-04journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/8196reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/81962026-06-02T12:44:21Z
dc.title.none.fl_str_mv Ankyrin Repeat and Kinase Domain Containing 1 Gene, and Addiction Vulnerability
title Ankyrin Repeat and Kinase Domain Containing 1 Gene, and Addiction Vulnerability
spellingShingle Ankyrin Repeat and Kinase Domain Containing 1 Gene, and Addiction Vulnerability
Koeneke, Alejandra
ANKK1
TaqIA
DRD2
addictions
dopamine
neurodevelopment
Neurociencias (Medicina)
Psiquiatría
2490 Neurociencias
3211 Psiquiatría
title_short Ankyrin Repeat and Kinase Domain Containing 1 Gene, and Addiction Vulnerability
title_full Ankyrin Repeat and Kinase Domain Containing 1 Gene, and Addiction Vulnerability
title_fullStr Ankyrin Repeat and Kinase Domain Containing 1 Gene, and Addiction Vulnerability
title_full_unstemmed Ankyrin Repeat and Kinase Domain Containing 1 Gene, and Addiction Vulnerability
title_sort Ankyrin Repeat and Kinase Domain Containing 1 Gene, and Addiction Vulnerability
dc.creator.none.fl_str_mv Koeneke, Alejandra
Ponce Alfaro, Guillermo
Troya-Balseca, Johanna
Palomo Álvarez, Tomás
Hoenicka, Janet
author Koeneke, Alejandra
author_facet Koeneke, Alejandra
Ponce Alfaro, Guillermo
Troya-Balseca, Johanna
Palomo Álvarez, Tomás
Hoenicka, Janet
author_role author
author2 Ponce Alfaro, Guillermo
Troya-Balseca, Johanna
Palomo Álvarez, Tomás
Hoenicka, Janet
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv ANKK1
TaqIA
DRD2
addictions
dopamine
neurodevelopment
Neurociencias (Medicina)
Psiquiatría
2490 Neurociencias
3211 Psiquiatría
topic ANKK1
TaqIA
DRD2
addictions
dopamine
neurodevelopment
Neurociencias (Medicina)
Psiquiatría
2490 Neurociencias
3211 Psiquiatría
description The TaqIA single nucleotide variant (SNV) has been tested for association with addictions in a huge number of studies. TaqIA is located in the ankyrin repeat and kinase domain containing 1 gene (ANKK1) that codes for a receptor interacting protein kinase. ANKK1 maps on the NTAD cluster along with the dopamine receptor D2 (DRD2), the tetratricopeptide repeat domain 12 (TTC12) and the neural cell adhesion molecule 1 (NCAM1) genes. The four genes have been associated with addictions, although TTC12 and ANKK1 showed the strongest associations. In silico and in vitro studies revealed that ANKK1 is functionally related to the dopaminergic system, in particular with DRD2. In antisocial alcoholism, epistasis between ANKK1 TaqIA and DRD2 C957T SNVs has been described. This clinical finding has been supported by the study of ANKK1 expression in peripheral blood mononuclear cells of alcoholic patients and controls. Regarding the ANKK1 protein, there is direct evidence of its location in adult and developing central nervous system. Together, these findings of the ANKK1 gene and its protein suggest that the TaqIA SNV is a marker of brain differences, both in structure and in dopaminergic function, that increase individual risk to addiction development.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-04-04
2020
2020-04-04
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/8196
url https://hdl.handle.net/20.500.14352/8196
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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