hDOS: an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision and in vivo validation

Significance: The hybrid diffuse optical system (hDOS) is a fully automated platform designed to bring advanced optical monitoring closer to clinical practice. Many existing systems lack automation, multiparametric output, and operator independence, limiting their use in demanding environments such...

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Autores: Zanoletti, M, Yaqub, MA, Cortese, L, Buttafava, M, García, JM, Amendola, C, Carteano, T, Frabasile, L, Garcia, DS, Guadagno, CN, Houtbeckers, T, Karadeniz, U, Lacerenza, M, Pagliazzi, M, Parsa, S, Wagenaar, T, Demarteau, L, Tomanik, J, Tosi, A, Weigel, UM, Sekar, SKV, Torricelli, A, Contini, D, Mesquida, J, Durduran, T
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p6725
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/6725
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105022314676&doi=10.1117%2F1.JBO.30.11.115004&partnerID=40&md5=201ccd1bf2d06601c11f7b38a94891e1
Access Level:acceso abierto
Palabra clave:hybrid diffuse optics
time-domain near infrared spectroscopy
diffuse correlation spectroscopy
intensive care
standardization
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spelling hDOS: an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision and in vivo validationZanoletti, MYaqub, MACortese, LButtafava, MGarcía, JMAmendola, CCarteano, TFrabasile, LGarcia, DSGuadagno, CNHoutbeckers, TKaradeniz, ULacerenza, MPagliazzi, MParsa, SWagenaar, TDemarteau, LTomanik, JTosi, AWeigel, UMSekar, SKVTorricelli, AContini, DMesquida, JDurduran, Thybrid diffuse opticstime-domain near infrared spectroscopydiffuse correlation spectroscopyintensive carestandardizationSignificance: The hybrid diffuse optical system (hDOS) is a fully automated platform designed to bring advanced optical monitoring closer to clinical practice. Many existing systems lack automation, multiparametric output, and operator independence, limiting their use in demanding environments such as intensive care. hDOS integrates time-domain near-infrared spectroscopy, diffuse correlation spectroscopy, and pulse oximetry to assess both tissue oxygenation and perfusion. Although initially developed in the context of vascular occlusion tests, its modular design makes it suitable for broader applications, including trauma, surgery, anesthesia, and studies in healthy subjects. Aim: It aims to design and validate hDOS, focusing on precision, repeatability, and usability for peripheral microvascular monitoring in both clinical and research settings. Approach: Validation included test-retest measurements, a 7-month clinical deployment in the critical care, and a comparison with a commercial continuous wave NIRS device (INVOS 5100C). Results: The device underwent extensive validation, accumulating over 200 h of usage across similar to 150 measurement sessions. The system showed high precision (test-retest CV <1.2% for oxygenation, <13% for perfusion), stable long-term performance, and lower variability than INVOS. It has also detected statistically significant differences during VOTs and detected hemodynamic impairment in ICU patients (n = 100) compared with healthy volunteers (n = 37).SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/6725https://www.scopus.com/inward/record.uri?eid=2-s2.0-105022314676&doi=10.1117%2F1.JBO.30.11.115004&partnerID=40&md5=201ccd1bf2d06601c11f7b38a94891e1JOURNAL OF BIOMEDICAL OPTICSISSN: 10833668ISSNe: 15602281reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p67252026-06-21T15:30:37Z
dc.title.none.fl_str_mv hDOS: an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision and in vivo validation
title hDOS: an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision and in vivo validation
spellingShingle hDOS: an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision and in vivo validation
Zanoletti, M
hybrid diffuse optics
time-domain near infrared spectroscopy
diffuse correlation spectroscopy
intensive care
standardization
title_short hDOS: an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision and in vivo validation
title_full hDOS: an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision and in vivo validation
title_fullStr hDOS: an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision and in vivo validation
title_full_unstemmed hDOS: an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision and in vivo validation
title_sort hDOS: an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision and in vivo validation
dc.creator.none.fl_str_mv Zanoletti, M
Yaqub, MA
Cortese, L
Buttafava, M
García, JM
Amendola, C
Carteano, T
Frabasile, L
Garcia, DS
Guadagno, CN
Houtbeckers, T
Karadeniz, U
Lacerenza, M
Pagliazzi, M
Parsa, S
Wagenaar, T
Demarteau, L
Tomanik, J
Tosi, A
Weigel, UM
Sekar, SKV
Torricelli, A
Contini, D
Mesquida, J
Durduran, T
author Zanoletti, M
author_facet Zanoletti, M
Yaqub, MA
Cortese, L
Buttafava, M
García, JM
Amendola, C
Carteano, T
Frabasile, L
Garcia, DS
Guadagno, CN
Houtbeckers, T
Karadeniz, U
Lacerenza, M
Pagliazzi, M
Parsa, S
Wagenaar, T
Demarteau, L
Tomanik, J
Tosi, A
Weigel, UM
Sekar, SKV
Torricelli, A
Contini, D
Mesquida, J
Durduran, T
author_role author
author2 Yaqub, MA
Cortese, L
Buttafava, M
García, JM
Amendola, C
Carteano, T
Frabasile, L
Garcia, DS
Guadagno, CN
Houtbeckers, T
Karadeniz, U
Lacerenza, M
Pagliazzi, M
Parsa, S
Wagenaar, T
Demarteau, L
Tomanik, J
Tosi, A
Weigel, UM
Sekar, SKV
Torricelli, A
Contini, D
Mesquida, J
Durduran, T
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv hybrid diffuse optics
time-domain near infrared spectroscopy
diffuse correlation spectroscopy
intensive care
standardization
topic hybrid diffuse optics
time-domain near infrared spectroscopy
diffuse correlation spectroscopy
intensive care
standardization
description Significance: The hybrid diffuse optical system (hDOS) is a fully automated platform designed to bring advanced optical monitoring closer to clinical practice. Many existing systems lack automation, multiparametric output, and operator independence, limiting their use in demanding environments such as intensive care. hDOS integrates time-domain near-infrared spectroscopy, diffuse correlation spectroscopy, and pulse oximetry to assess both tissue oxygenation and perfusion. Although initially developed in the context of vascular occlusion tests, its modular design makes it suitable for broader applications, including trauma, surgery, anesthesia, and studies in healthy subjects. Aim: It aims to design and validate hDOS, focusing on precision, repeatability, and usability for peripheral microvascular monitoring in both clinical and research settings. Approach: Validation included test-retest measurements, a 7-month clinical deployment in the critical care, and a comparison with a commercial continuous wave NIRS device (INVOS 5100C). Results: The device underwent extensive validation, accumulating over 200 h of usage across similar to 150 measurement sessions. The system showed high precision (test-retest CV <1.2% for oxygenation, <13% for perfusion), stable long-term performance, and lower variability than INVOS. It has also detected statistically significant differences during VOTs and detected hemodynamic impairment in ICU patients (n = 100) compared with healthy volunteers (n = 37).
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/6725
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105022314676&doi=10.1117%2F1.JBO.30.11.115004&partnerID=40&md5=201ccd1bf2d06601c11f7b38a94891e1
url https://i3pt.portalinvestigacion.com/publicaciones/6725
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105022314676&doi=10.1117%2F1.JBO.30.11.115004&partnerID=40&md5=201ccd1bf2d06601c11f7b38a94891e1
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
publisher.none.fl_str_mv SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
dc.source.none.fl_str_mv JOURNAL OF BIOMEDICAL OPTICS
ISSN: 10833668
ISSNe: 15602281
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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