"hDOS" an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision and in vivo validation

Significance: The hybrid diffuse optical system (hDOS) is a fully automated platform designed to bring advanced optical monitoring closer to clinical practice. Many existing systems lack automation, multiparametric output, and operator independence, limiting their use in demanding environments such...

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Detalles Bibliográficos
Autores: Zanoletti, Marta, Yaqub, Muhammad Atif, Cortese, Lorenzo, Buttafava, Mauro, Martínez García, Jacqueline, Amendola, Caterina, Carteano, Talyta, Frabasile, Lorenzo, Sanoja Garcia, Diego, Guadagno, Claudia nunzia, Houtbeckers, Tijl, Karadeniz, Umut, Lacerenza, Michele, Pagliazzi, Marco, Parsa, Shahrzad, Wagenaar, Tessa, Demarteau, Luc, Tomanik, Jakub, Tosi, Alberto, Weigel, Udo M, Sekar, Sanathana Konugolu Venkata, Torricelli, Alessandro, Contini, Davide, Mesquida, Jaume, Durduran, Turgut
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/459475
Acceso en línea:https://hdl.handle.net/2117/459475
Access Level:acceso abierto
Palabra clave:Spectrum analysis
Hybrid diffuse optical system
Diffuse optical spectroscopy
Diffuse optical imaging
Anàlisi espectral
Àrees temàtiques de la UPC::Física
Descripción
Sumario:Significance: The hybrid diffuse optical system (hDOS) is a fully automated platform designed to bring advanced optical monitoring closer to clinical practice. Many existing systems lack automation, multiparametric output, and operator independence, limiting their use in demanding environments such as intensive care. hDOS integrates time-domain near-infrared spectroscopy, diffuse correlation spectroscopy, and pulse oximetry to assess both tissue oxygenation and perfusion. Although initially developed in the context of vascular occlusion tests, its modular design makes it suitable for broader applications, including trauma, surgery, anesthesia, and studies in healthy subjects. Aim: It aims to design and validate hDOS, focusing on precision, repeatability, and usability for peripheral microvascular monitoring in both clinical and research settings. Approach: Validation included test-retest measurements, a 7-month clinical deployment in the critical care, and a comparison with a commercial continuous wave NIRS device (INVOS 5100C). Results: The device underwent extensive validation, accumulating over 200 h of usage across similar to 150 measurement sessions. The system showed high precision (test-retest CV

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