Neural and biomarker correlates of the Parkinson's Disease-Cognitive Rating Scale in Huntington's disease

Cognitive decline is a core feature of Huntington's disease (HD), often preceding motor symptoms and progressing with disease severity. While several neuropsychological tests track cognitive changes, few studies have examined the biological correlates of brief screening tools adapted for HD. Th...

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Detalles Bibliográficos
Autores: Martínez-Horta, Saul|||0000-0003-0125-7249, Puig-Davi, Arnau|||0000-0001-8883-4947, Sampedro, Frederic|||0000-0002-3933-1355, Pérez-Pérez, Jesús|||0000-0002-9835-0484, Franch-Martí, Carla, Olmedo-Saura, Gonzalo|||0000-0003-4864-5548, Rivas Asensio, Elisa, Vázquez-Oliver, Anna|||0000-0002-9842-7656, Pérez-Carasol, Laura, Horta-Barba, Andrea|||0000-0003-0050-5466, Pagonabarraga Mora, Javier|||0000-0002-3248-704X, Kulisevsky, Jaime|||0000-0003-4870-1431
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:dnet:uabarcelona_::4dc4bba39dd12a4e8e20bc7ad5bcc9bb
Acceso en línea:https://ddd.uab.cat/record/326355
https://dx.doi.org/urn:doi:10.1016/j.ynirp.2025.100311
Access Level:acceso abierto
Palabra clave:Huntington's disease
PD-CRS
Cognitive assessment
MRI
Neuropsychology
Descripción
Sumario:Cognitive decline is a core feature of Huntington's disease (HD), often preceding motor symptoms and progressing with disease severity. While several neuropsychological tests track cognitive changes, few studies have examined the biological correlates of brief screening tools adapted for HD. This study investigates the neuroanatomical and fluid biomarker correlates of performance on the Parkinson's Disease-Cognitive Rating Scale (PD-CRS), aiming to validate it as a clinically and biologically grounded tool for cognitive assessment in HD. Fifty-two symptomatic gene-expansion carriers (CAG.

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