Quatsomes Formulated with l-Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity

The efficacy of the treatment of bacterial infection is seriously reduced because of antibiotic resistance; thus, therapeutic solutions against drug-resistant microbes are necessary. Nanoparticle-based solutions are particularly promising for meeting this challenge because they can offer intrinsic a...

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Detalhes bibliográficos
Autores: Battista, Sara, Köber, Mariana, Bellio, Pierangelo, Celenza, Giuseppe, Galantini, Luciano, Vargas Nadal, Guillem, Fagnani, Lorenza, Veciana, Jaume, Ventosa, Nora, Giansanti, Luisa
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/278051
Acesso em linha:http://hdl.handle.net/10261/278051
https://api.elsevier.com/content/abstract/scopus_id/85130846842
Access Level:acceso abierto
Palavra-chave:(+)-usnic acid
Antibacterial activity
Antioxidant activity
Chemical structure-activity relationship
l -prolinol-derived surfactants
Nanovesicles
Quatsomes
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oai_identifier_str oai:digital.csic.es:10261/278051
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Quatsomes Formulated with l-Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity
title Quatsomes Formulated with l-Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity
spellingShingle Quatsomes Formulated with l-Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity
Battista, Sara
(+)-usnic acid
Antibacterial activity
Antioxidant activity
Chemical structure-activity relationship
l -prolinol-derived surfactants
Nanovesicles
Quatsomes
title_short Quatsomes Formulated with l-Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity
title_full Quatsomes Formulated with l-Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity
title_fullStr Quatsomes Formulated with l-Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity
title_full_unstemmed Quatsomes Formulated with l-Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity
title_sort Quatsomes Formulated with l-Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity
dc.creator.none.fl_str_mv Battista, Sara
Köber, Mariana
Bellio, Pierangelo
Celenza, Giuseppe
Galantini, Luciano
Vargas Nadal, Guillem
Fagnani, Lorenza
Veciana, Jaume
Ventosa, Nora
Giansanti, Luisa
author Battista, Sara
author_facet Battista, Sara
Köber, Mariana
Bellio, Pierangelo
Celenza, Giuseppe
Galantini, Luciano
Vargas Nadal, Guillem
Fagnani, Lorenza
Veciana, Jaume
Ventosa, Nora
Giansanti, Luisa
author_role author
author2 Köber, Mariana
Bellio, Pierangelo
Celenza, Giuseppe
Galantini, Luciano
Vargas Nadal, Guillem
Fagnani, Lorenza
Veciana, Jaume
Ventosa, Nora
Giansanti, Luisa
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Generalitat de Catalunya
European Commission
Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina (España)
Ministerio de Economía y Competitividad (España)
Köber, Mariana [0000-0001-9962-7900]
Galantini, Luciano [0000-0001-5484-2658]
Veciana, Jaume [0000-0003-1023-9923]
Ventosa, Nora [0000-0002-8008-4974]
Giansanti, Luisa [0000-0001-9056-0607]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv (+)-usnic acid
Antibacterial activity
Antioxidant activity
Chemical structure-activity relationship
l -prolinol-derived surfactants
Nanovesicles
Quatsomes
topic (+)-usnic acid
Antibacterial activity
Antioxidant activity
Chemical structure-activity relationship
l -prolinol-derived surfactants
Nanovesicles
Quatsomes
description The efficacy of the treatment of bacterial infection is seriously reduced because of antibiotic resistance; thus, therapeutic solutions against drug-resistant microbes are necessary. Nanoparticle-based solutions are particularly promising for meeting this challenge because they can offer intrinsic antimicrobial activity and sustained drug release at the target site. Herein, we present a newly developed nanovesicle system of the quatsome family, composed of l-prolinol-derived surfactants and cholesterol, which has noticeable antibacterial activity even on Gram-negative strains, demonstrating great potential for the treatment of bacterial infections. We optimized the vesicle stability and antibacterial activity by tuning the surfactant chain length and headgroup charge (cationic or zwitterionic) and show that these quatsomes can furthermore serve as nanocarriers of pharmaceutical actives, demonstrated here by the encapsulation of (+)-usnic acid, a natural substance with many pharmacological properties.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/278051
https://api.elsevier.com/content/abstract/scopus_id/85130846842
url http://hdl.handle.net/10261/278051
https://api.elsevier.com/content/abstract/scopus_id/85130846842
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105622RB-I00
info:eu-repo/grantAgreement/EC/H2020/712949
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2015-0496
info:eu-repo/grantAgreement/MICIU/Plan Estatal de investigación Científica y Técnica y de Innovación 2017-2020/CEX2019-000917-S
ACS applied nano materials
http://dx.doi.org/10.1021/acsanm.1c04365
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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spelling Quatsomes Formulated with l-Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant ActivityBattista, SaraKöber, MarianaBellio, PierangeloCelenza, GiuseppeGalantini, LucianoVargas Nadal, GuillemFagnani, LorenzaVeciana, JaumeVentosa, NoraGiansanti, Luisa(+)-usnic acidAntibacterial activityAntioxidant activityChemical structure-activity relationshipl -prolinol-derived surfactantsNanovesiclesQuatsomesThe efficacy of the treatment of bacterial infection is seriously reduced because of antibiotic resistance; thus, therapeutic solutions against drug-resistant microbes are necessary. Nanoparticle-based solutions are particularly promising for meeting this challenge because they can offer intrinsic antimicrobial activity and sustained drug release at the target site. Herein, we present a newly developed nanovesicle system of the quatsome family, composed of l-prolinol-derived surfactants and cholesterol, which has noticeable antibacterial activity even on Gram-negative strains, demonstrating great potential for the treatment of bacterial infections. We optimized the vesicle stability and antibacterial activity by tuning the surfactant chain length and headgroup charge (cationic or zwitterionic) and show that these quatsomes can furthermore serve as nanocarriers of pharmaceutical actives, demonstrated here by the encapsulation of (+)-usnic acid, a natural substance with many pharmacological properties.This work was financially supported by the Ministry of Economic Affairs and Digital Transformation (MINECO), Spain, through the “MOL4BIO” project (PID2019-105622RB-I00) and by Generalitat de Catalunya through Grant 2017-SGR-918. Furthermore, the research leading to these results has received funding from the European Union’s Horizon 2020 research and innovation program under Marie Skłodowska-Curie Grant Agreement 712949 (TECNIOspring PLUS) and from the Agency for Business Competitiveness of the Government of Catalonia. We also acknowledge the CIBER-BBN Early Stage project FlexCAB. The preparation of quatsomes and their characterization were performed by the ICTS “NANBIOSIS”, more specifically by the Biomaterial Processing and Nanostructuring Unit (U6), CIBER-BBN, located at ICMAB-CSIC. ICMAB-CSIC acknowledges support from MINECO through the Severo Ochoa Programme for Centres of Excellence in R&D (Grants SEV-2015-0496 and CEX2019-000917-S).With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000917-S).Peer reviewedAmerican Chemical SocietyMinisterio de Ciencia, Innovación y Universidades (España)Generalitat de CatalunyaEuropean CommissionCentro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina (España)Ministerio de Economía y Competitividad (España)Köber, Mariana [0000-0001-9962-7900]Galantini, Luciano [0000-0001-5484-2658]Veciana, Jaume [0000-0003-1023-9923]Ventosa, Nora [0000-0002-8008-4974]Giansanti, Luisa [0000-0001-9056-0607]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/278051https://api.elsevier.com/content/abstract/scopus_id/85130846842reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105622RB-I00info:eu-repo/grantAgreement/EC/H2020/712949info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2015-0496info:eu-repo/grantAgreement/MICIU/Plan Estatal de investigación Científica y Técnica y de Innovación 2017-2020/CEX2019-000917-SACS applied nano materialshttp://dx.doi.org/10.1021/acsanm.1c04365Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2780512026-05-22T06:33:51Z
score 15,81155

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