Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents

Antimicrobial peptides (AMPs) are important mediator molecules of the innate defense mechanisms in a wide range of living organisms, including bacteria, mammals, and plants. Among them, peptide protease inhibitors (PPIs) from plants play a central role in their defense mechanisms by directly attacki...

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Autores: Parisi, Mónica G.|||0000-0002-6167-1436, Ozón, Brenda|||0009-0003-6368-3742, Vera González, Sofía M.|||0009-0009-8317-4930, Garcia-Pardo, Javier|||0000-0001-9179-6371, Obregón, Walter David
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:293864
Acesso em linha:https://ddd.uab.cat/record/293864
https://dx.doi.org/urn:doi:10.3390/pharmaceutics16050582
Access Level:acceso abierto
Palavra-chave:Plant protease inhibitors
Antibacterial compounds
Antimicrobial activity
Antimicrobial peptides
Antibiotic resistance
Antifungal agents
Cysteine-rich peptides
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spelling Plant Protease Inhibitors as Emerging Antimicrobial Peptide AgentsA Comprehensive ReviewParisi, Mónica G.|||0000-0002-6167-1436Ozón, Brenda|||0009-0003-6368-3742Vera González, Sofía M.|||0009-0009-8317-4930Garcia-Pardo, Javier|||0000-0001-9179-6371Obregón, Walter DavidPlant protease inhibitorsAntibacterial compoundsAntimicrobial activityAntimicrobial peptidesAntibiotic resistanceAntifungal agentsCysteine-rich peptidesAntimicrobial peptides (AMPs) are important mediator molecules of the innate defense mechanisms in a wide range of living organisms, including bacteria, mammals, and plants. Among them, peptide protease inhibitors (PPIs) from plants play a central role in their defense mechanisms by directly attacking pathogens or by modulating the plant's defense response. The growing prevalence of microbial resistance to currently available antibiotics has intensified the interest concerning these molecules as novel antimicrobial agents. In this scenario, PPIs isolated from a variety of plants have shown potential in inhibiting the growth of pathogenic bacteria, protozoans, and fungal strains, either by interfering with essential biochemical or physiological processes or by altering the permeability of biological membranes of invading organisms. Moreover, these molecules are active inhibitors of a range of proteases, including aspartic, serine, and cysteine types, with some showing particular efficacy as trypsin and chymotrypsin inhibitors. In this review, we provide a comprehensive analysis of the potential of plant-derived PPIs as novel antimicrobial molecules, highlighting their broad-spectrum antimicrobial efficacy, specificity, and minimal toxicity. These natural compounds exhibit diverse mechanisms of action and often multifunctionality, positioning them as promising molecular scaffolds for developing new therapeutic antibacterial agents.Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular 22024-01-0120242024-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/293864https://dx.doi.org/urn:doi:10.3390/pharmaceutics16050582reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 IJC2019-041039-I)open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2938642026-06-06T12:50:31Z
dc.title.none.fl_str_mv Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents
A Comprehensive Review
title Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents
spellingShingle Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents
Parisi, Mónica G.|||0000-0002-6167-1436
Plant protease inhibitors
Antibacterial compounds
Antimicrobial activity
Antimicrobial peptides
Antibiotic resistance
Antifungal agents
Cysteine-rich peptides
title_short Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents
title_full Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents
title_fullStr Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents
title_full_unstemmed Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents
title_sort Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents
dc.creator.none.fl_str_mv Parisi, Mónica G.|||0000-0002-6167-1436
Ozón, Brenda|||0009-0003-6368-3742
Vera González, Sofía M.|||0009-0009-8317-4930
Garcia-Pardo, Javier|||0000-0001-9179-6371
Obregón, Walter David
author Parisi, Mónica G.|||0000-0002-6167-1436
author_facet Parisi, Mónica G.|||0000-0002-6167-1436
Ozón, Brenda|||0009-0003-6368-3742
Vera González, Sofía M.|||0009-0009-8317-4930
Garcia-Pardo, Javier|||0000-0001-9179-6371
Obregón, Walter David
author_role author
author2 Ozón, Brenda|||0009-0003-6368-3742
Vera González, Sofía M.|||0009-0009-8317-4930
Garcia-Pardo, Javier|||0000-0001-9179-6371
Obregón, Walter David
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
dc.subject.none.fl_str_mv Plant protease inhibitors
Antibacterial compounds
Antimicrobial activity
Antimicrobial peptides
Antibiotic resistance
Antifungal agents
Cysteine-rich peptides
topic Plant protease inhibitors
Antibacterial compounds
Antimicrobial activity
Antimicrobial peptides
Antibiotic resistance
Antifungal agents
Cysteine-rich peptides
description Antimicrobial peptides (AMPs) are important mediator molecules of the innate defense mechanisms in a wide range of living organisms, including bacteria, mammals, and plants. Among them, peptide protease inhibitors (PPIs) from plants play a central role in their defense mechanisms by directly attacking pathogens or by modulating the plant's defense response. The growing prevalence of microbial resistance to currently available antibiotics has intensified the interest concerning these molecules as novel antimicrobial agents. In this scenario, PPIs isolated from a variety of plants have shown potential in inhibiting the growth of pathogenic bacteria, protozoans, and fungal strains, either by interfering with essential biochemical or physiological processes or by altering the permeability of biological membranes of invading organisms. Moreover, these molecules are active inhibitors of a range of proteases, including aspartic, serine, and cysteine types, with some showing particular efficacy as trypsin and chymotrypsin inhibitors. In this review, we provide a comprehensive analysis of the potential of plant-derived PPIs as novel antimicrobial molecules, highlighting their broad-spectrum antimicrobial efficacy, specificity, and minimal toxicity. These natural compounds exhibit diverse mechanisms of action and often multifunctionality, positioning them as promising molecular scaffolds for developing new therapeutic antibacterial agents.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/293864
https://dx.doi.org/urn:doi:10.3390/pharmaceutics16050582
url https://ddd.uab.cat/record/293864
https://dx.doi.org/urn:doi:10.3390/pharmaceutics16050582
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 IJC2019-041039-I)
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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