Additional metabolic effects of bariatric surgery in patients with a poor mid-term weight loss response: a 5-year follow-up study

To ascertain the 5-year metabolic effects of bariatric surgery in poor weight loss (WL) responders and establish associated factors. Methods: Retrospective analysis of a non-randomised prospective cohort of bariatric surgery patients completing a 5-year follow-up. Mid-term poor WL was considered whe...

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Bibliographic Details
Authors: Benaiges Foix, David, Bisbe Maria, Pedro-Botet, Juan, Vargas-Machuca, Aleix de, Ramón Moros, José Manuel, Pera Román, Manuel, Villatoro Moreno, Montserrat, Fontane Francia, Laia, Julià, Helena, Climent, Elisenda, Castañer, Olga, Flores Le Roux, Juana Antonia, Goday Arnó, Albert
Format: article
Status:Published version
Publication Date:2020
Country:España
Institution:Universitat Pompeu Fabra
Repository:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/48649
Online Access:http://hdl.handle.net/10230/48649
http://dx.doi.org/10.3390/jcm9103193
Access Level:Open access
Keyword:Bariatric surgery
Gastric bypass
Obesity
Severe obesity
Sleeve gastrectomy
Weight loss
Weight regain
Description
Summary:To ascertain the 5-year metabolic effects of bariatric surgery in poor weight loss (WL) responders and establish associated factors. Methods: Retrospective analysis of a non-randomised prospective cohort of bariatric surgery patients completing a 5-year follow-up. Mid-term poor WL was considered when 5-year excess weight loss was <50%. Results: Forty-three (20.3%) of the 212 included patients were mid-term poor WL responders. They showed an improvement in all metabolic markers at 2 years, except for total cholesterol. This improvement with respect to baseline was maintained at 5 years for plasma glucose, HbA1c, HOMA, HDL and diastolic blood pressure; however, LDL cholesterol, triglycerides and systolic blood pressure were similar to presurgical values. Comorbidity remission rates were comparable to those obtained in the good WL group except for hypercholesterolaemia (45.8% vs. poor WL, p = 0.005). On multivariate analysis, lower baseline HDL cholesterol levels, advanced age and lower preoperative weight loss were independently associated with poor mid-term WL. Conclusions: Although that 1 in 5 patients presented suboptimal WL 5 years after bariatric surgery, other important metabolic benefits were maintained.

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