Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion.

Padilla, Maria; Coll, Elisabeth; Fernandez-Perez, Cristina; Pont, Teresa; Ruiz, Angel; Perez-Redondo, Marina; Oliver, Eva; Atutxa, Lander; Mancino, Jose M; Daga, Domingo; Minambres, Eduardo; Moya, Jose; Vidal, Barbara; Duenas-Jurado, Jose M; Mosteiro, Fernando; Rodriguez-Salgado, Alberto; Fernandez-Garcia, Esperanza; Lara, Ramon; Hernandez-Marrero, Domingo; Estebanez, Belen; Rodriguez-Ferrero, M Luisa; Barber, Maria; Garcia-Lopez, Fernando; Andres, Amado; Santiago, Carlos; Zapatero, Ana; Badenes, Rafael; Carrizosa, Francisco; Blanco, Jose J; Bernal, Jose L; Elola, Francisco J; Vidal, Cristina; Terron, Christel; Castro, Pablo; Comas, Jordi; Dominguez-Gil, Beatriz

Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion.

Normothermic regional perfusion (NRP) allows the in situ perfusion of organs with oxygenated blood in donation after the circulatory determination of death (DCDD). We aimed at evaluating the impact of NRP on the short-term outcomes of kidney transplants in controlled DCDD (cDCDD). This is a multicen...

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Autores:	Padilla, Maria, Coll, Elisabeth, Fernandez-Perez, Cristina, Pont, Teresa, Ruiz, Angel, Perez-Redondo, Marina, Oliver, Eva, Atutxa, Lander, Mancino, Jose M, Daga, Domingo, Minambres, Eduardo, Moya, Jose, Vidal, Barbara, Duenas-Jurado, Jose M, Mosteiro, Fernando, Rodriguez-Salgado, Alberto, Fernandez-Garcia, Esperanza, Lara, Ramon, Hernandez-Marrero, Domingo, Estebanez, Belen, Rodriguez-Ferrero, M Luisa, Barber, Maria, Garcia-Lopez, Fernando, Andres, Amado, Santiago, Carlos, Zapatero, Ana, Badenes, Rafael, Carrizosa, Francisco, Blanco, Jose J, Bernal, Jose L, Elola, Francisco J, Vidal, Cristina, Terron, Christel, Castro, Pablo, Comas, Jordi, Dominguez-Gil, Beatriz
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2021
País:	España
Institución:	INCLIVA
Repositorio:	r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:	oai:incliva.fundanetsuite.com:p15692
Acceso en línea:	https://incliva.portalinvestigacion.com/publicaciones/15692
Access Level:	acceso abierto
Palabra clave:	clinical research / practice delayed graft function (DGF) donors and donation: donation after circulatory death (DCD) graft survival kidney transplantation / nephrology organ perfusion and preservation organ procurement and allocation

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spelling	Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion.Padilla, MariaColl, ElisabethFernandez-Perez, CristinaPont, TeresaRuiz, AngelPerez-Redondo, MarinaOliver, EvaAtutxa, LanderMancino, Jose MDaga, DomingoMinambres, EduardoMoya, JoseVidal, BarbaraDuenas-Jurado, Jose MMosteiro, FernandoRodriguez-Salgado, AlbertoFernandez-Garcia, EsperanzaLara, RamonHernandez-Marrero, DomingoEstebanez, BelenRodriguez-Ferrero, M LuisaBarber, MariaGarcia-Lopez, FernandoAndres, AmadoSantiago, CarlosZapatero, AnaBadenes, RafaelCarrizosa, FranciscoBlanco, Jose JBernal, Jose LElola, Francisco JVidal, CristinaTerron, ChristelCastro, PabloComas, JordiDominguez-Gil, Beatrizclinical research / practicedelayed graft function (DGF)donors and donation: donation after circulatory death (DCD)graft survivalkidney transplantation / nephrologyorgan perfusion and preservationorgan procurement and allocationNormothermic regional perfusion (NRP) allows the in situ perfusion of organs with oxygenated blood in donation after the circulatory determination of death (DCDD). We aimed at evaluating the impact of NRP on the short-term outcomes of kidney transplants in controlled DCDD (cDCDD). This is a multicenter, nationwide, retrospective study comparing cDCDD kidneys obtained with NRP versus the standard rapid recovery (RR) technique. During 2012-2018, 2302 cDCDD adult kidney transplants were performed in Spain using NRP (n = 865) or RR (n = 1437). The study groups differed in donor and recipient age, warm, and cold ischemic time and use of ex situ machine perfusion. Transplants in the NRP group were more frequently performed in high-volume centers (=90 transplants/year). Through matching by propensity score, two cohorts with a total of 770 patients were obtained. After the matching, no statistically significant differences were observed between the groups in terms of primary nonfunction (p = .261) and mortality at 1 year (p = .111). However, the RR of kidneys was associated with a significantly increased odds of delayed graft function (OR 1.97 [95% CI 1.43-2.72]; p < .001) and 1-year graft loss (OR 1.77 [95% CI 1.01-3.17]; p = .034). In conclusion, compared with RR, NRP appears to improve the short-term outcomes of cDCDD kidney transplants.ELSEVIER SCIENCE INC2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/15692AMERICAN JOURNAL OF TRANSPLANTATIONISSN: 16006135ISSNe: 16006143reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p156922026-06-07T16:35:31Z
dc.title.none.fl_str_mv	Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion.
title	Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion.
spellingShingle	Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion. Padilla, Maria clinical research / practice delayed graft function (DGF) donors and donation: donation after circulatory death (DCD) graft survival kidney transplantation / nephrology organ perfusion and preservation organ procurement and allocation
title_short	Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion.
title_full	Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion.
title_fullStr	Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion.
title_full_unstemmed	Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion.
title_sort	Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion.
dc.creator.none.fl_str_mv	Padilla, Maria Coll, Elisabeth Fernandez-Perez, Cristina Pont, Teresa Ruiz, Angel Perez-Redondo, Marina Oliver, Eva Atutxa, Lander Mancino, Jose M Daga, Domingo Minambres, Eduardo Moya, Jose Vidal, Barbara Duenas-Jurado, Jose M Mosteiro, Fernando Rodriguez-Salgado, Alberto Fernandez-Garcia, Esperanza Lara, Ramon Hernandez-Marrero, Domingo Estebanez, Belen Rodriguez-Ferrero, M Luisa Barber, Maria Garcia-Lopez, Fernando Andres, Amado Santiago, Carlos Zapatero, Ana Badenes, Rafael Carrizosa, Francisco Blanco, Jose J Bernal, Jose L Elola, Francisco J Vidal, Cristina Terron, Christel Castro, Pablo Comas, Jordi Dominguez-Gil, Beatriz
author	Padilla, Maria
author_facet	Padilla, Maria Coll, Elisabeth Fernandez-Perez, Cristina Pont, Teresa Ruiz, Angel Perez-Redondo, Marina Oliver, Eva Atutxa, Lander Mancino, Jose M Daga, Domingo Minambres, Eduardo Moya, Jose Vidal, Barbara Duenas-Jurado, Jose M Mosteiro, Fernando Rodriguez-Salgado, Alberto Fernandez-Garcia, Esperanza Lara, Ramon Hernandez-Marrero, Domingo Estebanez, Belen Rodriguez-Ferrero, M Luisa Barber, Maria Garcia-Lopez, Fernando Andres, Amado Santiago, Carlos Zapatero, Ana Badenes, Rafael Carrizosa, Francisco Blanco, Jose J Bernal, Jose L Elola, Francisco J Vidal, Cristina Terron, Christel Castro, Pablo Comas, Jordi Dominguez-Gil, Beatriz
author_role	author
author2	Coll, Elisabeth Fernandez-Perez, Cristina Pont, Teresa Ruiz, Angel Perez-Redondo, Marina Oliver, Eva Atutxa, Lander Mancino, Jose M Daga, Domingo Minambres, Eduardo Moya, Jose Vidal, Barbara Duenas-Jurado, Jose M Mosteiro, Fernando Rodriguez-Salgado, Alberto Fernandez-Garcia, Esperanza Lara, Ramon Hernandez-Marrero, Domingo Estebanez, Belen Rodriguez-Ferrero, M Luisa Barber, Maria Garcia-Lopez, Fernando Andres, Amado Santiago, Carlos Zapatero, Ana Badenes, Rafael Carrizosa, Francisco Blanco, Jose J Bernal, Jose L Elola, Francisco J Vidal, Cristina Terron, Christel Castro, Pablo Comas, Jordi Dominguez-Gil, Beatriz
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	clinical research / practice delayed graft function (DGF) donors and donation: donation after circulatory death (DCD) graft survival kidney transplantation / nephrology organ perfusion and preservation organ procurement and allocation
topic	clinical research / practice delayed graft function (DGF) donors and donation: donation after circulatory death (DCD) graft survival kidney transplantation / nephrology organ perfusion and preservation organ procurement and allocation
description	Normothermic regional perfusion (NRP) allows the in situ perfusion of organs with oxygenated blood in donation after the circulatory determination of death (DCDD). We aimed at evaluating the impact of NRP on the short-term outcomes of kidney transplants in controlled DCDD (cDCDD). This is a multicenter, nationwide, retrospective study comparing cDCDD kidneys obtained with NRP versus the standard rapid recovery (RR) technique. During 2012-2018, 2302 cDCDD adult kidney transplants were performed in Spain using NRP (n = 865) or RR (n = 1437). The study groups differed in donor and recipient age, warm, and cold ischemic time and use of ex situ machine perfusion. Transplants in the NRP group were more frequently performed in high-volume centers (=90 transplants/year). Through matching by propensity score, two cohorts with a total of 770 patients were obtained. After the matching, no statistically significant differences were observed between the groups in terms of primary nonfunction (p = .261) and mortality at 1 year (p = .111). However, the RR of kidneys was associated with a significantly increased odds of delayed graft function (OR 1.97 [95% CI 1.43-2.72]; p < .001) and 1-year graft loss (OR 1.77 [95% CI 1.01-3.17]; p = .034). In conclusion, compared with RR, NRP appears to improve the short-term outcomes of cDCDD kidney transplants.
publishDate	2021
dc.date.none.fl_str_mv	2021
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://incliva.portalinvestigacion.com/publicaciones/15692
url	https://incliva.portalinvestigacion.com/publicaciones/15692
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	ELSEVIER SCIENCE INC
publisher.none.fl_str_mv	ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv	AMERICAN JOURNAL OF TRANSPLANTATION ISSN: 16006135 ISSNe: 16006143 reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname:INCLIVA
instname_str	INCLIVA
reponame_str	r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection	r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.812429

Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion.

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