Voltammetric determination of active pharmaceutical ingredients using screen-printed electrodes
A simple, fast, sensitive and low-cost voltammetric method using a screen-printed carbon electrode (SPCE) is presented in this work for the simultaneous determination of ascorbic acid (AA), paracetamol (PA), dextromethorphan (DX) and caffeine (CF) in both pharmaceutical formulations and samples of e...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/185916 |
| Acceso en línea: | https://hdl.handle.net/2445/185916 |
| Access Level: | acceso abierto |
| Palabra clave: | Voltametria Cafeïna Elèctrodes Voltammetry Caffeine Electrodes |
| Sumario: | A simple, fast, sensitive and low-cost voltammetric method using a screen-printed carbon electrode (SPCE) is presented in this work for the simultaneous determination of ascorbic acid (AA), paracetamol (PA), dextromethorphan (DX) and caffeine (CF) in both pharmaceutical formulations and samples of environmental interest. The oxidative peak current displayed linear dependence on concentration within the range 1.7-60.5, 0.6-40.0, 0.9-8.4 (1st linear part) and 1.8-22.0 mg L-1 for AA, PA, DX and CF, respectively; and detection limits of 0.5, 0.2, 0.3 and 0.5 mg L-1, respectively. The developed differential pulse voltammetric (DPV) method was validated using both a pharmaceutical product and a spiked well water sample. A very good agreement between the determined and the theoretical label drug content and recoveries in the range of 99.5-100.8% were obtained for pharmaceutical product and well water samples, respectively. |
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