Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines

Severe Middle East respiratory syndrome (MERS) is characterized by massive infiltration of immune cells in lungs. MERS-coronavirus (MERS-CoV) replicates in vitro in human macrophages, inducing high pro-inflammatory responses. In contrast, camelids, the main reservoir for MERS-CoV, are asymptomatic c...

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Autores: Rodon, Jordi|||0000-0002-1032-9091, Sachse, Martin, Te, Nigeer|||0000-0002-5794-5764, Segalés Coma, Joaquim|||0000-0002-1539-7261, Bensaid, Albert|||0000-0001-6493-3756, Risco, Cristina|||0000-0001-7501-5934, Vergara-Alert, Júlia|||0000-0001-7484-444X
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:307611
Acceso en línea:https://ddd.uab.cat/record/307611
https://dx.doi.org/urn:doi:10.1016/j.micinf.2023.105252
Access Level:acceso abierto
Palabra clave:Alveolar macrophages
Immune responses
Llama
MERS-CoV
Middle East respiratory syndrome coronavirus
Pro-inflammatory cytokines
SDG 3 - Good Health and Well-being
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spelling Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokinesRodon, Jordi|||0000-0002-1032-9091Sachse, MartinTe, Nigeer|||0000-0002-5794-5764Segalés Coma, Joaquim|||0000-0002-1539-7261Bensaid, Albert|||0000-0001-6493-3756Risco, Cristina|||0000-0001-7501-5934Vergara-Alert, Júlia|||0000-0001-7484-444XAlveolar macrophagesImmune responsesLlamaMERS-CoVMiddle East respiratory syndrome coronavirusPro-inflammatory cytokinesSDG 3 - Good Health and Well-beingSevere Middle East respiratory syndrome (MERS) is characterized by massive infiltration of immune cells in lungs. MERS-coronavirus (MERS-CoV) replicates in vitro in human macrophages, inducing high pro-inflammatory responses. In contrast, camelids, the main reservoir for MERS-CoV, are asymptomatic carriers. Although limited infiltration of leukocytes has been observed in the lower respiratory tract of camelids, their role during infection remains unknown. Here we studied whether llama alveolar macrophages (LAMs) are susceptible to MERS-CoV infection and can elicit pro-inflammatory responses. MERS-CoV did not replicate in LAMs; however, they effectively capture and degrade viral particles. Moreover, transcriptomic analyses showed that LAMs do not induce pro-inflammatory cytokines upon MERS-CoV sensing. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/307611https://dx.doi.org/urn:doi:10.1016/j.micinf.2023.105252reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3076112026-06-06T12:50:31Z
dc.title.none.fl_str_mv Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
title Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
spellingShingle Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
Rodon, Jordi|||0000-0002-1032-9091
Alveolar macrophages
Immune responses
Llama
MERS-CoV
Middle East respiratory syndrome coronavirus
Pro-inflammatory cytokines
SDG 3 - Good Health and Well-being
title_short Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
title_full Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
title_fullStr Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
title_full_unstemmed Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
title_sort Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
dc.creator.none.fl_str_mv Rodon, Jordi|||0000-0002-1032-9091
Sachse, Martin
Te, Nigeer|||0000-0002-5794-5764
Segalés Coma, Joaquim|||0000-0002-1539-7261
Bensaid, Albert|||0000-0001-6493-3756
Risco, Cristina|||0000-0001-7501-5934
Vergara-Alert, Júlia|||0000-0001-7484-444X
author Rodon, Jordi|||0000-0002-1032-9091
author_facet Rodon, Jordi|||0000-0002-1032-9091
Sachse, Martin
Te, Nigeer|||0000-0002-5794-5764
Segalés Coma, Joaquim|||0000-0002-1539-7261
Bensaid, Albert|||0000-0001-6493-3756
Risco, Cristina|||0000-0001-7501-5934
Vergara-Alert, Júlia|||0000-0001-7484-444X
author_role author
author2 Sachse, Martin
Te, Nigeer|||0000-0002-5794-5764
Segalés Coma, Joaquim|||0000-0002-1539-7261
Bensaid, Albert|||0000-0001-6493-3756
Risco, Cristina|||0000-0001-7501-5934
Vergara-Alert, Júlia|||0000-0001-7484-444X
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Alveolar macrophages
Immune responses
Llama
MERS-CoV
Middle East respiratory syndrome coronavirus
Pro-inflammatory cytokines
SDG 3 - Good Health and Well-being
topic Alveolar macrophages
Immune responses
Llama
MERS-CoV
Middle East respiratory syndrome coronavirus
Pro-inflammatory cytokines
SDG 3 - Good Health and Well-being
description Severe Middle East respiratory syndrome (MERS) is characterized by massive infiltration of immune cells in lungs. MERS-coronavirus (MERS-CoV) replicates in vitro in human macrophages, inducing high pro-inflammatory responses. In contrast, camelids, the main reservoir for MERS-CoV, are asymptomatic carriers. Although limited infiltration of leukocytes has been observed in the lower respiratory tract of camelids, their role during infection remains unknown. Here we studied whether llama alveolar macrophages (LAMs) are susceptible to MERS-CoV infection and can elicit pro-inflammatory responses. MERS-CoV did not replicate in LAMs; however, they effectively capture and degrade viral particles. Moreover, transcriptomic analyses showed that LAMs do not induce pro-inflammatory cytokines upon MERS-CoV sensing.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/307611
https://dx.doi.org/urn:doi:10.1016/j.micinf.2023.105252
url https://ddd.uab.cat/record/307611
https://dx.doi.org/urn:doi:10.1016/j.micinf.2023.105252
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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