Epidemiological and molecular analysis of virulence and antibiotic resistance in Acinetobacter baumannii

Acinetobacter baumannii is a highly versatile nosocomial pathogen that is implicated in several nosocomial infections among critically ill patients and results in high mortality rates. These infections include ventilator associated pneumonia, bloodstream infections, urinary tract infections, and bur...

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Detalhes bibliográficos
Autor: Dahdouh, Elias
Tipo de documento: tese
Data de publicação:2017
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositório:Docta Complutense
Idioma:inglês
OAI Identifier:oai:docta.ucm.es:20.500.14352/22447
Acesso em linha:https://hdl.handle.net/20.500.14352/22447
Access Level:Acceso aberto
Palavra-chave:579.62(043.2)
Veterinary bacteriology
Bacteriología veterinaria
Microbiología (Veterinaria)
3109.05 Microbiología
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spelling Epidemiological and molecular analysis of virulence and antibiotic resistance in Acinetobacter baumanniiAnálisis epidemiológico y molecular de la virulencia y la antibiorresistencia en Acinetobacter baumanniiDahdouh, Elias579.62(043.2)Veterinary bacteriologyBacteriología veterinariaMicrobiología (Veterinaria)3109.05 MicrobiologíaAcinetobacter baumannii is a highly versatile nosocomial pathogen that is implicated in several nosocomial infections among critically ill patients and results in high mortality rates. These infections include ventilator associated pneumonia, bloodstream infections, urinary tract infections, and burn wound infections. Multi-Drug Resistant (MDR), and especially Carbapenem Resistant Acinetobacter baumannii (CRAB) isolates are also sharply increasing in frequency, forcing clinicians to revert to the use of colistin. This organism has numerous intrinsic resistance mechanisms, virulence determinants, and an elastic genome that allows it to acquire resistance to almost all antimicrobial agents rather easily. The acquisition of oxacillinases (OXAs) is one of the most common mechanisms of acquiring carbapenem resistance. Moreover, some clinically important International Clones (ICs) with MDR profiles are disseminated all over the world. A. baumannii is known to differentially express virulence determinants and few studies hint at their relationship with antimicrobial resistance. However, this relationship is not extensively investigated. In this Doctoral Thesis, the relationship between clonality, virulence, and antimicrobial resistance is investigated in two sets of clinical isolates obtained from Spain and Lebanon, two countries in which the rate of CRAB isolates is notoriously high. Our aim is providing clinicians and infection control specialists with tools that could be used to assess the infecting strain based on initial clinical data that could improve the chances of successful therapy and limit the spread of MDR and CRAB isolates. Additionally, it is our aim to better understand the interaction between virulence and antibiotic resistance...Universidad Complutense de MadridSuárez Rodríguez, MónicaUniversidad Complutense de Madrid20172017-08-0220172017-08-02doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/22447reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/224472026-06-02T12:44:21Z
dc.title.none.fl_str_mv Epidemiological and molecular analysis of virulence and antibiotic resistance in Acinetobacter baumannii
Análisis epidemiológico y molecular de la virulencia y la antibiorresistencia en Acinetobacter baumannii
title Epidemiological and molecular analysis of virulence and antibiotic resistance in Acinetobacter baumannii
spellingShingle Epidemiological and molecular analysis of virulence and antibiotic resistance in Acinetobacter baumannii
Dahdouh, Elias
579.62(043.2)
Veterinary bacteriology
Bacteriología veterinaria
Microbiología (Veterinaria)
3109.05 Microbiología
title_short Epidemiological and molecular analysis of virulence and antibiotic resistance in Acinetobacter baumannii
title_full Epidemiological and molecular analysis of virulence and antibiotic resistance in Acinetobacter baumannii
title_fullStr Epidemiological and molecular analysis of virulence and antibiotic resistance in Acinetobacter baumannii
title_full_unstemmed Epidemiological and molecular analysis of virulence and antibiotic resistance in Acinetobacter baumannii
title_sort Epidemiological and molecular analysis of virulence and antibiotic resistance in Acinetobacter baumannii
dc.creator.none.fl_str_mv Dahdouh, Elias
author Dahdouh, Elias
author_facet Dahdouh, Elias
author_role author
dc.contributor.none.fl_str_mv Suárez Rodríguez, Mónica
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 579.62(043.2)
Veterinary bacteriology
Bacteriología veterinaria
Microbiología (Veterinaria)
3109.05 Microbiología
topic 579.62(043.2)
Veterinary bacteriology
Bacteriología veterinaria
Microbiología (Veterinaria)
3109.05 Microbiología
description Acinetobacter baumannii is a highly versatile nosocomial pathogen that is implicated in several nosocomial infections among critically ill patients and results in high mortality rates. These infections include ventilator associated pneumonia, bloodstream infections, urinary tract infections, and burn wound infections. Multi-Drug Resistant (MDR), and especially Carbapenem Resistant Acinetobacter baumannii (CRAB) isolates are also sharply increasing in frequency, forcing clinicians to revert to the use of colistin. This organism has numerous intrinsic resistance mechanisms, virulence determinants, and an elastic genome that allows it to acquire resistance to almost all antimicrobial agents rather easily. The acquisition of oxacillinases (OXAs) is one of the most common mechanisms of acquiring carbapenem resistance. Moreover, some clinically important International Clones (ICs) with MDR profiles are disseminated all over the world. A. baumannii is known to differentially express virulence determinants and few studies hint at their relationship with antimicrobial resistance. However, this relationship is not extensively investigated. In this Doctoral Thesis, the relationship between clonality, virulence, and antimicrobial resistance is investigated in two sets of clinical isolates obtained from Spain and Lebanon, two countries in which the rate of CRAB isolates is notoriously high. Our aim is providing clinicians and infection control specialists with tools that could be used to assess the infecting strain based on initial clinical data that could improve the chances of successful therapy and limit the spread of MDR and CRAB isolates. Additionally, it is our aim to better understand the interaction between virulence and antibiotic resistance...
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-08-02
2017
2017-08-02
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/22447
url https://hdl.handle.net/20.500.14352/22447
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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