Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging

Amyloid-beta (Aβ) plaques and tau neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD); their contribution to neurodegeneration and clinical manifestations are critical in understanding preclinical AD. At present, the mechanisms related to Aβ and tau pathogenesis leadi...

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Autores: Kim, Chan-Mi|||0000-0001-5686-1668, Montal, Victor|||0000-0002-5714-9282, Diez, Ibai, Orwig, William, Sepulcre, Jorge|||0000-0002-4199-2304
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:243795
Acesso em linha:https://ddd.uab.cat/record/243795
https://dx.doi.org/urn:doi:10.1002/hbm.25350
Access Level:acceso abierto
Palavra-chave:Aging
Alzheimer's disease
Amyloid PET
Cognition
Connectivity analysis
Tau PET
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spelling Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in agingKim, Chan-Mi|||0000-0001-5686-1668Montal, Victor|||0000-0002-5714-9282Diez, IbaiOrwig, WilliamSepulcre, Jorge|||0000-0002-4199-2304AgingAlzheimer's diseaseAmyloid PETCognitionConnectivity analysisTau PETAmyloid-beta (Aβ) plaques and tau neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD); their contribution to neurodegeneration and clinical manifestations are critical in understanding preclinical AD. At present, the mechanisms related to Aβ and tau pathogenesis leading to cognitive decline in older adults remain largely unknown. Here, we examined graph theory-based positron emission tomography (PET) analytical approaches, within and between tau and Aβ PET modalities, and tested the effects on cognitive changes in cognitively normal older adults (CN). Particularly, we focused on the network interdigitations of Aβ and tau deposits, along with cognitive test scores in CN at both baseline and 2-year follow-up (FU). We found highly significant Aβ-tau network integrations in AD vulnerable areas, as well as significant associations between those Aβ-tau interdigitations and general cognitive impairment in CN at baseline and FU. Our findings suggest a distinctive contribution of interlinking network relationships between Aβ and tau deposits in heteromodal areas of the human brain. They support a network-based interaction between Aβ and tau accumulations as a key factor for cognitive deterioration in CN prior to dementia. We examined network interaction patterns within single positron emission tomography (PET) modality, such as Aß-to-Aß or Tau-to-Tau correlations, and between different PET modalities, such as Aß-to-Tau or Tau-to-Aß, at high-resolution (voxel-level) in cognitively normal older adults (CN), using a graph theory-based analysis. We observed that the PET uptakes derived from Aß-to-Tau interdigitations were significantly associated with Alzheimer's Disease Assessment Scale-Cognitive Subscale in AD vulnerable brain areas, a finding confirmed by our longitudinal investigation. Therefore, our work suggests the preceding contribution of network interactions between Aß and tau deposits to explain initial cognitive changes in CN prior to the conversion of dementia.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/243795https://dx.doi.org/urn:doi:10.1002/hbm.25350reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2437952026-06-06T12:50:31Z
dc.title.none.fl_str_mv Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
title Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
spellingShingle Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
Kim, Chan-Mi|||0000-0001-5686-1668
Aging
Alzheimer's disease
Amyloid PET
Cognition
Connectivity analysis
Tau PET
title_short Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
title_full Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
title_fullStr Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
title_full_unstemmed Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
title_sort Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
dc.creator.none.fl_str_mv Kim, Chan-Mi|||0000-0001-5686-1668
Montal, Victor|||0000-0002-5714-9282
Diez, Ibai
Orwig, William
Sepulcre, Jorge|||0000-0002-4199-2304
author Kim, Chan-Mi|||0000-0001-5686-1668
author_facet Kim, Chan-Mi|||0000-0001-5686-1668
Montal, Victor|||0000-0002-5714-9282
Diez, Ibai
Orwig, William
Sepulcre, Jorge|||0000-0002-4199-2304
author_role author
author2 Montal, Victor|||0000-0002-5714-9282
Diez, Ibai
Orwig, William
Sepulcre, Jorge|||0000-0002-4199-2304
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Aging
Alzheimer's disease
Amyloid PET
Cognition
Connectivity analysis
Tau PET
topic Aging
Alzheimer's disease
Amyloid PET
Cognition
Connectivity analysis
Tau PET
description Amyloid-beta (Aβ) plaques and tau neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD); their contribution to neurodegeneration and clinical manifestations are critical in understanding preclinical AD. At present, the mechanisms related to Aβ and tau pathogenesis leading to cognitive decline in older adults remain largely unknown. Here, we examined graph theory-based positron emission tomography (PET) analytical approaches, within and between tau and Aβ PET modalities, and tested the effects on cognitive changes in cognitively normal older adults (CN). Particularly, we focused on the network interdigitations of Aβ and tau deposits, along with cognitive test scores in CN at both baseline and 2-year follow-up (FU). We found highly significant Aβ-tau network integrations in AD vulnerable areas, as well as significant associations between those Aβ-tau interdigitations and general cognitive impairment in CN at baseline and FU. Our findings suggest a distinctive contribution of interlinking network relationships between Aβ and tau deposits in heteromodal areas of the human brain. They support a network-based interaction between Aβ and tau accumulations as a key factor for cognitive deterioration in CN prior to dementia. We examined network interaction patterns within single positron emission tomography (PET) modality, such as Aß-to-Aß or Tau-to-Tau correlations, and between different PET modalities, such as Aß-to-Tau or Tau-to-Aß, at high-resolution (voxel-level) in cognitively normal older adults (CN), using a graph theory-based analysis. We observed that the PET uptakes derived from Aß-to-Tau interdigitations were significantly associated with Alzheimer's Disease Assessment Scale-Cognitive Subscale in AD vulnerable brain areas, a finding confirmed by our longitudinal investigation. Therefore, our work suggests the preceding contribution of network interactions between Aß and tau deposits to explain initial cognitive changes in CN prior to the conversion of dementia.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/243795
https://dx.doi.org/urn:doi:10.1002/hbm.25350
url https://ddd.uab.cat/record/243795
https://dx.doi.org/urn:doi:10.1002/hbm.25350
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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