Impact on allergic immune response after treatment with vitamin A

Background: Vitamin A may have some influence on the immune system, but the role in allergy modulation is still unclear. Objective: To clarify whether high levels of retinoic acid (RA) affects allergic response in vivo, we used a murine experimental model of airway allergic disease. Methods: Ovalbum...

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Detalles Bibliográficos
Autores: Matheu V, Berggård K,, Barrios Y,, Arnau MR, Zubeldia Ortuño, José Manuel, Baeza ML, Back O, Issazadeh-Navikas S
Tipo de recurso: artículo
Fecha de publicación:2009
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/115717
Acceso en línea:https://hdl.handle.net/20.500.14352/115717
Access Level:acceso abierto
Palabra clave:616-056.3
Alergias
Vitamina A
Alergología
3299 Otras Especialidades Médicas
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oai_identifier_str oai:docta.ucm.es:20.500.14352/115717
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repository_id_str
spelling Impact on allergic immune response after treatment with vitamin AMatheu VBerggård K,Barrios Y,Barrios Y,Arnau MRZubeldia Ortuño, José ManuelBaeza MLBack OIssazadeh-Navikas S616-056.3AlergiasVitamina AAlergología3299 Otras Especialidades MédicasBackground: Vitamin A may have some influence on the immune system, but the role in allergy modulation is still unclear. Objective: To clarify whether high levels of retinoic acid (RA) affects allergic response in vivo, we used a murine experimental model of airway allergic disease. Methods: Ovalbumin (OVA)-immunization/OVA-challenge (OVA/OVA) and house dust mite (HDM)-immunization/HDM-challenge (HDM/HDM) experimental murine models of allergic airway disease, using C57Bl.10/Q groups of mice (n = 10) treated subcutaneously with different concentrations of all-trans RA (0, 50, 500 and 2,500 ug) every 2-days were used to assess the allergic immune response. Results: Levels of total and specific-IgE in sera were increased in all groups of RA treated OVA/OVA and HDM/HDM mice. Percentage and total amount of recruited eosinophil in airways by bronchoalveolar lavage fluid (BALF) were significantly enhanced in groups treated with 50, 500 and 2,500 ug of RA compared to non-treated mice. However, the group of mice treated with 2,500 ug had less eosinophil recruitment than the other two groups (50 and 500 ug). In parallel, levels of IL-5 and total IgE in BALF were also significantly diminished in the group treated with 2,500 ug compared to the other 2 groups (50 and 500 ug). Finally, total lung resistance was decreased in group treated with 2,500 ug compared to non-treated mice. Conclusion: Our results suggest that retinoic acid directly enhances allergic response in vivo, but in higher doses may produce of immune suppression.BioMed CentralUniversidad Complutense de Madrid20092009-10-2320092009-10-23journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/115717reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1157172026-06-02T12:44:21Z
dc.title.none.fl_str_mv Impact on allergic immune response after treatment with vitamin A
title Impact on allergic immune response after treatment with vitamin A
spellingShingle Impact on allergic immune response after treatment with vitamin A
Matheu V
616-056.3
Alergias
Vitamina A
Alergología
3299 Otras Especialidades Médicas
title_short Impact on allergic immune response after treatment with vitamin A
title_full Impact on allergic immune response after treatment with vitamin A
title_fullStr Impact on allergic immune response after treatment with vitamin A
title_full_unstemmed Impact on allergic immune response after treatment with vitamin A
title_sort Impact on allergic immune response after treatment with vitamin A
dc.creator.none.fl_str_mv Matheu V
Berggård K,
Barrios Y,
Barrios Y,
Arnau MR
Zubeldia Ortuño, José Manuel
Baeza ML
Back O
Issazadeh-Navikas S
author Matheu V
author_facet Matheu V
Berggård K,
Barrios Y,
Arnau MR
Zubeldia Ortuño, José Manuel
Baeza ML
Back O
Issazadeh-Navikas S
author_role author
author2 Berggård K,
Barrios Y,
Arnau MR
Zubeldia Ortuño, José Manuel
Baeza ML
Back O
Issazadeh-Navikas S
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616-056.3
Alergias
Vitamina A
Alergología
3299 Otras Especialidades Médicas
topic 616-056.3
Alergias
Vitamina A
Alergología
3299 Otras Especialidades Médicas
description Background: Vitamin A may have some influence on the immune system, but the role in allergy modulation is still unclear. Objective: To clarify whether high levels of retinoic acid (RA) affects allergic response in vivo, we used a murine experimental model of airway allergic disease. Methods: Ovalbumin (OVA)-immunization/OVA-challenge (OVA/OVA) and house dust mite (HDM)-immunization/HDM-challenge (HDM/HDM) experimental murine models of allergic airway disease, using C57Bl.10/Q groups of mice (n = 10) treated subcutaneously with different concentrations of all-trans RA (0, 50, 500 and 2,500 ug) every 2-days were used to assess the allergic immune response. Results: Levels of total and specific-IgE in sera were increased in all groups of RA treated OVA/OVA and HDM/HDM mice. Percentage and total amount of recruited eosinophil in airways by bronchoalveolar lavage fluid (BALF) were significantly enhanced in groups treated with 50, 500 and 2,500 ug of RA compared to non-treated mice. However, the group of mice treated with 2,500 ug had less eosinophil recruitment than the other two groups (50 and 500 ug). In parallel, levels of IL-5 and total IgE in BALF were also significantly diminished in the group treated with 2,500 ug compared to the other 2 groups (50 and 500 ug). Finally, total lung resistance was decreased in group treated with 2,500 ug compared to non-treated mice. Conclusion: Our results suggest that retinoic acid directly enhances allergic response in vivo, but in higher doses may produce of immune suppression.
publishDate 2009
dc.date.none.fl_str_mv 2009
2009-10-23
2009
2009-10-23
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/115717
url https://hdl.handle.net/20.500.14352/115717
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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