Automatic Assessment of the 2-Minute Walk Distance for Remote Monitoring of People with Multiple Sclerosis

The aim of this study was to investigate the feasibility of automatically assessing the 2-Minute Walk Distance (2MWD) for monitoring people with multiple sclerosis (pwMS). For 154 pwMS, MS-related clinical outcomes as well as the 2MWDs as evaluated by clinicians and derived from accelerometer data w...

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Autores: Kontaxis, Spyridon|||0000-0002-1297-0691, Laporta, Estela|||0000-0001-6776-8522, Garcia, Esther|||0000-0003-3997-493X, Martinis, Matteo, Leocani, Letizia|||0000-0001-9326-6753, Roselli, Lucia, Buron, Mathias Due|||0000-0003-1260-1156, Guerrero, Ana Isabel|||0000-0001-5891-2123, Zabalza, Ana|||0000-0003-3860-5251, Cummins, Nicholas, Vairavan, Srinivasan, Hotopf, Matthew|||0000-0002-3980-4466, Dobson, Richard James Butler|||0000-0003-4224-9245, Narayan, Vaibhav A., La Porta, Maria Libera, Costa, Gloria Dalla, Magyari, Melinda|||0000-0002-0972-5222, Sørensen, Per S|||0000-0002-2818-3780, Nos, Carlos|||0000-0002-3830-4910, Bailón, Raquel|||0000-0003-1272-0550, Comi, Giancarlo|||0000-0002-6989-1054
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:284678
Acesso em linha:https://ddd.uab.cat/record/284678
https://dx.doi.org/urn:doi:10.3390/s23136017
Access Level:acceso abierto
Palavra-chave:Accelerometer sensor
Disability level
Fatigue severity
Walk tests
Wearable device
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spelling Automatic Assessment of the 2-Minute Walk Distance for Remote Monitoring of People with Multiple SclerosisKontaxis, Spyridon|||0000-0002-1297-0691Laporta, Estela|||0000-0001-6776-8522Garcia, Esther|||0000-0003-3997-493XMartinis, MatteoLeocani, Letizia|||0000-0001-9326-6753Roselli, LuciaBuron, Mathias Due|||0000-0003-1260-1156Guerrero, Ana Isabel|||0000-0001-5891-2123Zabalza, Ana|||0000-0003-3860-5251Cummins, NicholasVairavan, SrinivasanHotopf, Matthew|||0000-0002-3980-4466Dobson, Richard James Butler|||0000-0003-4224-9245Narayan, Vaibhav A.La Porta, Maria LiberaCosta, Gloria DallaMagyari, Melinda|||0000-0002-0972-5222Sørensen, Per S|||0000-0002-2818-3780Nos, Carlos|||0000-0002-3830-4910Bailón, Raquel|||0000-0003-1272-0550Comi, Giancarlo|||0000-0002-6989-1054Accelerometer sensorDisability levelFatigue severityWalk testsWearable deviceThe aim of this study was to investigate the feasibility of automatically assessing the 2-Minute Walk Distance (2MWD) for monitoring people with multiple sclerosis (pwMS). For 154 pwMS, MS-related clinical outcomes as well as the 2MWDs as evaluated by clinicians and derived from accelerometer data were collected from a total of 323 periodic clinical visits. Accelerometer data from a wearable device during 100 home-based 2MWD assessments were also acquired. The error in estimating the 2MWD was validated for walk tests performed at hospital, and then the correlation (r) between clinical outcomes and home-based 2MWD assessments was evaluated. Robust performance in estimating the 2MWD from the wearable device was obtained, yielding an error of less than 10% in about two-thirds of clinical visits. Correlation analysis showed that there is a strong association between the actual and the estimated 2MWD obtained either at hospital (r = 0.71) or at home (r = 0.58). Furthermore, the estimated 2MWD exhibits moderate-to-strong correlation with various MS-related clinical outcomes, including disability and fatigue severity scores. Automatic assessment of the 2MWD in pwMS is feasible with the usage of a consumer-friendly wearable device in clinical and non-clinical settings. Wearable devices can also enhance the assessment of MS-related clinical outcomes. 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/284678https://dx.doi.org/urn:doi:10.3390/s23136017reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2846782026-06-06T12:50:31Z
dc.title.none.fl_str_mv Automatic Assessment of the 2-Minute Walk Distance for Remote Monitoring of People with Multiple Sclerosis
title Automatic Assessment of the 2-Minute Walk Distance for Remote Monitoring of People with Multiple Sclerosis
spellingShingle Automatic Assessment of the 2-Minute Walk Distance for Remote Monitoring of People with Multiple Sclerosis
Kontaxis, Spyridon|||0000-0002-1297-0691
Accelerometer sensor
Disability level
Fatigue severity
Walk tests
Wearable device
title_short Automatic Assessment of the 2-Minute Walk Distance for Remote Monitoring of People with Multiple Sclerosis
title_full Automatic Assessment of the 2-Minute Walk Distance for Remote Monitoring of People with Multiple Sclerosis
title_fullStr Automatic Assessment of the 2-Minute Walk Distance for Remote Monitoring of People with Multiple Sclerosis
title_full_unstemmed Automatic Assessment of the 2-Minute Walk Distance for Remote Monitoring of People with Multiple Sclerosis
title_sort Automatic Assessment of the 2-Minute Walk Distance for Remote Monitoring of People with Multiple Sclerosis
dc.creator.none.fl_str_mv Kontaxis, Spyridon|||0000-0002-1297-0691
Laporta, Estela|||0000-0001-6776-8522
Garcia, Esther|||0000-0003-3997-493X
Martinis, Matteo
Leocani, Letizia|||0000-0001-9326-6753
Roselli, Lucia
Buron, Mathias Due|||0000-0003-1260-1156
Guerrero, Ana Isabel|||0000-0001-5891-2123
Zabalza, Ana|||0000-0003-3860-5251
Cummins, Nicholas
Vairavan, Srinivasan
Hotopf, Matthew|||0000-0002-3980-4466
Dobson, Richard James Butler|||0000-0003-4224-9245
Narayan, Vaibhav A.
La Porta, Maria Libera
Costa, Gloria Dalla
Magyari, Melinda|||0000-0002-0972-5222
Sørensen, Per S|||0000-0002-2818-3780
Nos, Carlos|||0000-0002-3830-4910
Bailón, Raquel|||0000-0003-1272-0550
Comi, Giancarlo|||0000-0002-6989-1054
author Kontaxis, Spyridon|||0000-0002-1297-0691
author_facet Kontaxis, Spyridon|||0000-0002-1297-0691
Laporta, Estela|||0000-0001-6776-8522
Garcia, Esther|||0000-0003-3997-493X
Martinis, Matteo
Leocani, Letizia|||0000-0001-9326-6753
Roselli, Lucia
Buron, Mathias Due|||0000-0003-1260-1156
Guerrero, Ana Isabel|||0000-0001-5891-2123
Zabalza, Ana|||0000-0003-3860-5251
Cummins, Nicholas
Vairavan, Srinivasan
Hotopf, Matthew|||0000-0002-3980-4466
Dobson, Richard James Butler|||0000-0003-4224-9245
Narayan, Vaibhav A.
La Porta, Maria Libera
Costa, Gloria Dalla
Magyari, Melinda|||0000-0002-0972-5222
Sørensen, Per S|||0000-0002-2818-3780
Nos, Carlos|||0000-0002-3830-4910
Bailón, Raquel|||0000-0003-1272-0550
Comi, Giancarlo|||0000-0002-6989-1054
author_role author
author2 Laporta, Estela|||0000-0001-6776-8522
Garcia, Esther|||0000-0003-3997-493X
Martinis, Matteo
Leocani, Letizia|||0000-0001-9326-6753
Roselli, Lucia
Buron, Mathias Due|||0000-0003-1260-1156
Guerrero, Ana Isabel|||0000-0001-5891-2123
Zabalza, Ana|||0000-0003-3860-5251
Cummins, Nicholas
Vairavan, Srinivasan
Hotopf, Matthew|||0000-0002-3980-4466
Dobson, Richard James Butler|||0000-0003-4224-9245
Narayan, Vaibhav A.
La Porta, Maria Libera
Costa, Gloria Dalla
Magyari, Melinda|||0000-0002-0972-5222
Sørensen, Per S|||0000-0002-2818-3780
Nos, Carlos|||0000-0002-3830-4910
Bailón, Raquel|||0000-0003-1272-0550
Comi, Giancarlo|||0000-0002-6989-1054
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Accelerometer sensor
Disability level
Fatigue severity
Walk tests
Wearable device
topic Accelerometer sensor
Disability level
Fatigue severity
Walk tests
Wearable device
description The aim of this study was to investigate the feasibility of automatically assessing the 2-Minute Walk Distance (2MWD) for monitoring people with multiple sclerosis (pwMS). For 154 pwMS, MS-related clinical outcomes as well as the 2MWDs as evaluated by clinicians and derived from accelerometer data were collected from a total of 323 periodic clinical visits. Accelerometer data from a wearable device during 100 home-based 2MWD assessments were also acquired. The error in estimating the 2MWD was validated for walk tests performed at hospital, and then the correlation (r) between clinical outcomes and home-based 2MWD assessments was evaluated. Robust performance in estimating the 2MWD from the wearable device was obtained, yielding an error of less than 10% in about two-thirds of clinical visits. Correlation analysis showed that there is a strong association between the actual and the estimated 2MWD obtained either at hospital (r = 0.71) or at home (r = 0.58). Furthermore, the estimated 2MWD exhibits moderate-to-strong correlation with various MS-related clinical outcomes, including disability and fatigue severity scores. Automatic assessment of the 2MWD in pwMS is feasible with the usage of a consumer-friendly wearable device in clinical and non-clinical settings. Wearable devices can also enhance the assessment of MS-related clinical outcomes.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/284678
https://dx.doi.org/urn:doi:10.3390/s23136017
url https://ddd.uab.cat/record/284678
https://dx.doi.org/urn:doi:10.3390/s23136017
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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